Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology

Glujovsky, Demián; Farquhar, Cindy; Retamar, Andrea Marta Quinteiro; Sedo, Cristian Roberto Alvarez; Blake, Deborah

doi:10.1002/14651858.cd002118.pub5

Cited by 372 publications

(213 citation statements)

References 95 publications

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“…A recent metaanalysis showed that there is a small advantage in performing blastocyst transfer compared to cleavage stage transfer when considering the live birth rates. However, these results were observed only in good prognosis patients and the cumulative clinical pregnancy rates were higher for cleavage stage transfer when compared to blastocyst transfer [28]. In our IVF center the cleavage stage embryo transfer was a routine procedure in the study period.…”

Section: Discussionmentioning

confidence: 86%

Ratio of progesterone-to-number of follicles as a prognostic tool for in vitro fertilization cycles

Roque

Valle

Sampaio

et al. 2015

J Assist Reprod Genet

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Purpose To establish a ratio of the P level to the number of follicles (P/F ratio) on the day of human chorionic gonadotropin (hCG) administration and to evaluate whether this ratio is associated with in vitro fertilization (IVF) outcome. Methods This study was conducted between January 2012 and June 2013. A total of 337 patients with cleavage-stage day-3 fresh embryo transfer with P levels ≤1.5 ng/mL on the day of hCG administration were included in the study. The main outcome was ongoing pregnancy rate. Result(s) The P/F ratio was calculated according to the equation (P[ng/mL]/number of follicles) on the day of final oocyte maturation. Using ROC, we established a cut-off level of 0.075 for the P/F ratio. The area under the curve (AUC) (0.756; 95 % confidence interval [CI]: 0.704-0.807) indicated that it was a good prognostic test. In group 1 (patients under 36 years old), the ongoing pregnancy rates were 57 and 30 % for patients with P/F ratios≤.075 and>.075, respectively, (p= 0.003). In group 2 (patients between 36 and 39 years old), the ongoing pregnancy rates were 58 % and 17 % (p=0.001) for patients with P/F ratios ≤.075 and>.075, respectively. In group 3 (patients≥40 years old), the ongoing pregnancy rates were 41.7 and 10.9 % (p=0.001) for patients with P/F ratios≤.075 and>.075, respectively. Conclusions The P/F ratio is a good prognostic test for predicting IVF outcome that can correlate the P level with ovarian response.

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Section: Discussionmentioning

confidence: 86%

Ratio of progesterone-to-number of follicles as a prognostic tool for in vitro fertilization cycles

Roque

Valle

Sampaio

et al. 2015

J Assist Reprod Genet

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“…The recent literature on blastocyst transfers supports an improved pregnancy rate as opposed to cycle day 3 transfers [35,36]. A move of all transfers to blastocyst-stage embryos will also improve the live birth rates per transfer by removing from the denominator the cases failing to reach blastocyst stage embryos.…”

Section: Discussionmentioning

confidence: 99%

Embryo wastage rates remain high in assisted reproductive technology (ART): a look at the trends from 2004–2013 in the USA

Ghazal¹,

Patrizio²

2016

J Assist Reprod Genet

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This work examined the trend in Bembryo wastager ates after ART in USA and its relationship to the number of embryos transferred, live born infants delivered across patient age, and the yearly percentage of embryos wasted. The data were obtained from the US-clinics SART databank for the years 2004-2013. A total of 1,808,082 non-donor embryos were transferred in 748,394 fresh cycles resulting in 358,214 liveborn. During the years of analysis, the mean number of embryos transferred has progressively decreased leading to an overall significant decrease in Embryo Wastage rates (83.2 to 76.5%, p < 0.001) while the percentage of transfers leading to a live born increased (24.8 to 27.8%, p = 0.002). Embryo Wastage negatively correlated with percentage of transfers resulting in live birth (p = 0.001), and the average number of embryos transferred positively correlated with the percentage of embryos wasted (p < 0.001). The overwhelming majority of embryos transferred still do not result into a live birth confirming that only few embryos per ART cycle are competent. The overall BEmbryo Wastage^rates have consistently decreased from a high of 90% in 1995 to a rate of 76.5% in 2013. Transferring fewer embryos particularly at the blastocyst-stage and improved methods of embryo selection may further decrease BEmbryo Wastage^rates.

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“…Others have stagnated as the discourse continues over single or sequential media [5,6], compositional variants, and their influence on gene expression patterns in media comparisons [7]. In the end, even the question of what stage to transfer-cleavage or blastocyst-lingers while properly executed RCTs loom in a background of mediocrity in terms of clinical decision making [8].…”

Section: Commentarymentioning

confidence: 99%

Reformatting the reproductive tract to accommodate the needs of human ARTs

Albertini

2017

J Assist Reprod Genet

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Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology

Abstract: Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. Cochrane Database of Systematic Reviews.

Cited by 372 publications

References 95 publications

Ratio of progesterone-to-number of follicles as a prognostic tool for in vitro fertilization cycles

Ratio of progesterone-to-number of follicles as a prognostic tool for in vitro fertilization cycles

Embryo wastage rates remain high in assisted reproductive technology (ART): a look at the trends from 2004–2013 in the USA

Reformatting the reproductive tract to accommodate the needs of human ARTs

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