Abstract:Coxsackievirus B (CVB) 3C protease (3Cpro) plays a specific cleavage role on AU-rich binding factor (AUF1, also called hnRNP D), which consequently disputes the regulation of AUF1 on downstream molecules. In our study, the iTRAQ approach was first used to quantify the differentially expressed cellular proteins in AUF1-overexpressing HeLa cells, which provides straightforward insight into the role of AUF1 during viral infection. A total of 1,290 differentially expressed proteins (DEPs), including 882 upregulate… Show more
“…TA can inhibit b-ketoacyl-ACP reductase, bind with bacterial cell wall peptidoglycan, and increase cytoplasmic membrane permeability and instability. [45][46][47] These in vitro antibacterial results strongly indicate the success of in vivo release of TA by the hydrogel to treat infected diabetic wounds.…”
Section: Antibacterial and Hemostatic Propertiesmentioning
The clinical treatment of chronic diabetic wounds is a long-standing thorny issue. Strategies targeting the diabetic micro-environment have been developed to promote wound healing. However, it remains challenging to reverse...
“…TA can inhibit b-ketoacyl-ACP reductase, bind with bacterial cell wall peptidoglycan, and increase cytoplasmic membrane permeability and instability. [45][46][47] These in vitro antibacterial results strongly indicate the success of in vivo release of TA by the hydrogel to treat infected diabetic wounds.…”
Section: Antibacterial and Hemostatic Propertiesmentioning
The clinical treatment of chronic diabetic wounds is a long-standing thorny issue. Strategies targeting the diabetic micro-environment have been developed to promote wound healing. However, it remains challenging to reverse...
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