Clearing the air on pollutant disruptions of the gut-brain axis: Developmental exposure to Benzo[a]pyrene disturbs zebrafish behavior and the gut microbiome in adults and subsequent generations
Alexandra Alexiev,
Ebony Stretch,
Kristin D. Kasschau
et al.
Abstract:Developmental exposure to benzo[a]pyrene (BaP), a ubiquitous environmental pollutant, has been linked to various toxic effects, including neurodegenerative disorders and, most recently, multigenerational behavioral impairment. While the specific mechanisms driving BaP neurotoxicity are not fully understood, recent work highlights two important determinants of developmental BaP neurotoxicity: (1) the aryl hydrocarbon receptor (AHR), which is responsible for inducing host metabolism of BaP, and (2) the gut micro… Show more
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