Clearer Connections:

Regulation of neuronal type genes in congestive heart failure rats

“…Ddr1 might therefore have a functional role in cardiac nerve regeneration in MI hearts. Taken together, these data suggest that genes involved in cardiac nerve function and/or innervation are activated in CHF rats, thus giving support to the 'nerve-sprouting' hypothesis as a mechanism for arrhythmia development and sudden death (Chen et al 2001, Lathrop 2004. It is well recognized that sympathetic tone is increased in CHF.…”

“…Taken together, these data suggest that genes involved in cardiac nerve function and/or innervation are activated in CHF rats, thus giving support to the ‘nerve‐sprouting’ hypothesis as a mechanism for arrhythmia development and sudden death (Chen et al. 2001, Lathrop 2004).…”

“…The neurotrophin nerve growth factor (NGF) is produced locally in the heart, and is thought to play a role in nerve regeneration and maintenance (Hiltunen et al. 2001, Lathrop 2004, Zhou et al. 2004).…”

“…It has been suggested that nerve sprouting and sympathetic hyperinnervation may be an underlying mechanism for the arrhythmias and sudden death commonly observed after MI (Chen et al 2001, Lathrop 2004). The neurotrophin nerve growth factor (NGF) is produced locally in the heart, and is thought to play a role in nerve regeneration and maintenance (Hiltunen et al 2001, Lathrop 2004, Zhou et al 2004. We found that the NGF receptor (Ngfr) was upregulated fivefold in CHF hearts.…”

“…Recently, it has been suggested that processes such as nerve sprouting and sympathetic hyperinnervation may play important roles in the development of arrhythmias and sudden death in CHF patients (Chen et al. 2001, Lathrop 2004). It may therefore be likely that the identification of neuronal type genes with altered expression may shed light on processes involved in CHF‐associated arrhythmias and sudden death.…”