Clearance tests to assess liver function state of animals using compounds with high hepatic metabolism
Vladimir Ponamarev,
Olga Popova,
Anastasia Kostrova
et al.
Abstract:The article is devoted to the study of the medicinal substances metabolism in the liver and the possibility of using clearance tests with lidocaine and caffeine in veterinary medicine. It has been established that liver is the main organ where metabolism takes place, which is carried out in two stages involving the reactions of microsomal oxidation of fermentable cytochrome P450. Substances with a high metabolic rate undergo presystemic elimination. In liver pathologies, the metabolism of xenobiotics changes, … Show more
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