Clear cells of Toker in accessory nipples

Abstract

If you are looking for a broad overview of diseases of the hair and scalp look no further! This text is concise and consists mainly of definitions and brief descriptions of hair and scalp diseases. As you would expect in an atlas, treatment is not the emphasis. The strength of this atlas revolves around 240 high quality pictures, sometimes hard to find in general dermatology textbooks because they represent rare diseases. The pictures are mainly clinical, but one can find a good number of light microscopy and electron microscopy illustrations of hair shaft. There are only a few scalp biopsy illustrations. The book is divided into nine chapters and gives a glimpse of the physiology of hair growth, hair shaft abnormalities, alopecia, excess of hair and abnormalities of the scalp including inflammatory, infectious and tumoral diseases. A 2-hour reading for a dermatologist in training, or a dermatopathologist seeking clinical exposure, will pay back by providing excellent clinical descriptions of a wide variety of hair and scalp diseases.

Toker cells of the breast. Morphological and immunohistochemical characterization of 40 cases

“…In the original paper, it was suggested that TC may be of mammary origin, either as abortive glands or as migratory ductal cells. Few subsequent studies tried to address this issue [3,4]. The anedoctical finding of TC within the accessory nipple [3] is in keeping with an origin from abortive mammary glands.…”

“…Few subsequent studies tried to address this issue [3,4]. The anedoctical finding of TC within the accessory nipple [3] is in keeping with an origin from abortive mammary glands. By contrast, Marucci et al [4] showed that TC are ultrastructurally similar to ductal cells, likely being migratory elements.…”

“…A few studies have tried to clarify TC histogenesis: some suggested TC as true abortive mammary elements [2,3]; others favored the hypothesis of migratory ductal cells [4]. Much more interest was given to the relationship with PD in terms of both morphological [5,6] and immunohistochemical features [4,5,7,8].…”

Clear Cell Papulosis in Hispanic Siblings

“…3, 11 Toker cells do not stain with mucin stains, whereas Paget cells do. The CCP cells in most reported cases are positive for mucin, but the staining is variable.…”

“…They are also found in accessory nipples, and thus it is speculated that they are a normal component of the epidermis along the milk line. 11 There seems to be a histologic and immunohistochemical similarity between the clear cells of CCP and both Toker cells and Paget cells. All stain positively for cytokeratin, carcinoembryonic antigen, and epithelial membrane antigen and negatively for S100.…”