Clear Cell Variant of Calcifying Epithelial Odontogenic Tumor: A Case Report and Preliminary Immunohistochemical Study of the SHH Pathway

Júnior, Bráulio Carneiro; Muniz, Vinícius Rio Verde Melo; Vidal, Manuela Torres Andion; Gurgel, Clarissa Araújo Silva; Azevedo, Roberto Almeida de; Rebello, Iêda C.; Santos, Jean Nunes dos

doi:10.1097/pai.0000000000000467

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…The pathogenesis of CEOT is not clearly characterized, with proposed mechanisms conflicting. It has been theorized the SHH pathway is implicated in the pathogenesis of CEOT [58,59] ; however, initial NGS data does not support this [18,60]. Five CEOTs analyze with NGS revealed mutations in tumor suppressor genes PTEN and CDKN2A as well as oncogenes MET and JAK3 and mutations [60].…”

Section: Uncommon/diagnostically Challenging Odontogenic Tumorsmentioning

confidence: 96%

Update on Odontogenic Tumors: Proceedings of the North American Head and Neck Pathology Society

Bilodeau

Seethala

2019

Head and Neck Pathol

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Section: Uncommon/diagnostically Challenging Odontogenic Tumorsmentioning

confidence: 96%

Update on Odontogenic Tumors: Proceedings of the North American Head and Neck Pathology Society

Bilodeau

Seethala

2019

Head and Neck Pathol

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CEOT Variants or Entities: Time for a Rethink? A Case Series with Review of the Literature

Siriwardena

Speight

Franklin

et al. 2020

Head and Neck Pathol

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The first detailed description of calcifying epithelial odontogenic tumor (CEOT) are ascribed to Jens Pindborg, but this tumor was described some years previously. Subsequently, CEOT was included in the 1971 WHO classification of odontogenic tumors and a since then number of variants have been described, which have added confusion to the diagnostic criteria. We aimed to survey the literature on the variants of CEOT, in parallel with a review of our single institution experience of CEOTs. Cases identified were collated, including available clinical, radiological and histological information and then reviewed, taking into account changes in the understanding and classifications of odontogenic tumors since initial diagnosis. We identified 26 cases from 1975 to 2017 for which histological material was available. Of these, only 13 (50%) showed the "classic" histological appearance, whilst two cases were identified as recognized variants. In 11 cases, other diagnoses or a differential diagnosis were preferred, with no agreed diagnosis in four of these. The proliferation fraction (Ki67) in the 10 cases tested was 2.1% ± 0.18. These findings illustrate the diagnostic challenges in this group of tumors and highlight the gaps in knowledge. Techniques, such as EWSR1 gene cytogenetic analysis, may be helpful in cases with clear cells. However, in other areas of controversy, including the non-calcifying and Langerhans cell rich variants, further investigation, perhaps utilizing sequencing technologies may be needed to refine the classification. Owing to the relative rarity of these lesions it would be beneficial if future work could be pursued as an international collaboration.

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Clear Cell Variant of Calcifying Epithelial Odontogenic Tumor: A Case Report and Preliminary Immunohistochemical Study of the SHH Pathway

Cited by 2 publications

References 9 publications

Update on Odontogenic Tumors: Proceedings of the North American Head and Neck Pathology Society

Update on Odontogenic Tumors: Proceedings of the North American Head and Neck Pathology Society

CEOT Variants or Entities: Time for a Rethink? A Case Series with Review of the Literature

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