Clear Cell Sarcoma of the Kidney with Invasion of the Inferior Vena cava

Abstract

Objective: We present a case of clear cell sarcoma of the kidney (CCSK) in 53-year-old white man who was treated with surgery. This case represents the oldest patient with CCSK published in the English literature. Methods: Right radical nephrectomy with lymphadenectomy and thrombectomy was performed. Results: Histological findings indicated a CCSK. Tumor cells showed positive vimentin staining. Conclusion: CCSK is considered a rare and highly malignant renal tumor. The malignant nature may relate not only to the biological features of these tumor cells, but also to the high resistance against radiation and chemotherapy. The treatment of CCSK has been a subject of controversy.

Adult Clear Cell Sarcoma of the Kidney: Review of literature and a case report

“…In addition, Bhayani et al noted that a patient treated with surgery and combination chemotherapy (actinomycin, vincristine and doxorubicin) was disease-free at 12 months postoperatively [7]. In a report published by Rosso and colleagues, they treated a patient with surgery alone and stated that CCSK has a high resistance against radiation and chemotherapy [8].…”

Clear cell sarcoma of kidney: A rare entity

“…[8] Tumor cells are not reactive for Cytokeratin, EMA, MIC2, S100, Synaptophysin, GFAP, LCA, and NSE.…”

Adult clear cell sarcoma of the kidney: A case report

“…In addition, Bhayani et al noted that a patient treated with surgery and combination chemotherapy (actinomycin, vincristine and doxorubicin) was disease-free at 12 months postoperatively [3]. In a report recently published by Rosso and colleagues, they treated a patient with surgery alone and stated that CCSK has a high resistance against radiation and chemotherapy [4]. …”

“…Optimal treatment of adult patients with CCSK remains unclear. Surgery, radiotherapy and chemotherapy are combined or used separately [2-4]. Advanced clear cell renal carcinoma is highly resistant to traditional cytotoxic chemotherapeutic drugs, and chemotherapy alone has yielded disappointing responses in patients with renal cell carcinoma [5].…”