Clear cell sarcoma of tendons and aponeuroses

Abstract

Specification factors regulate cell fate in part by interacting with transcriptional co‐regulators like CtBP to regulate gene expression. Here, we demonstrate that CtBP forms a complex or complexes with the Drosophila melanogaster Pax6 homolog Eyeless (Ey), and with Distal antenna (Dan), Distal antenna related (Danr), and Dachshund to promote eye and antennal specification. Phenotypic analysis together with molecular data indicate that CtBP interacts with Ey to prevent overproliferation of eye precursors. In contrast, CtBP,dan,danr triple mutant adult eyes have significantly fewer ommatidia than CtBP single or dan,danr double mutants, suggesting that the CtBP/Dan/Danr complex functions to recruit ommatidia from the eye precursor pool. Furthermore, CtBP single and to a greater extent CtBP,dan,danr triple mutants affect the establishment and maintenance of the R8 precursor, which is the founding ommatidial cell. Thus, CtBP interacts with different eye specification factors to regulate gene expression appropriate for proliferative vs. differentiative stages of eye development. Developmental Dynamics 239:2367–2385, 2010. © 2010 Wiley‐Liss, Inc.

Global Protein-expression Analysis of Bone and Soft Tissue Sarcomas

“…Hierarchical clustering demonstrated leiomyosarcoma and MFH shared a similar protein expression profile, some of which was not distinguishable on the basis of protein expression, and that clear cell sarcoma, synovial sarcoma, and MPNST were grouped according to their protein expression patterns. These results were generally consistent with previous reports based on histologic and transcriptome analyses [7,13,19,25,[30][31][32].…”

“…Clear cell sarcoma is also known as melanoma of soft parts and is derived from neural crest progenitor cells [19]. Nagayama et al [30] reported synovial sarcoma and MPNST shared similar expression patterns of numerous genes related to neural differentiation and suggested synovial sarcoma might be of neuroectodermal origin.…”

“…Wide excision of tumors in conjunction with multiagent chemotherapy now provides 5-year diseasespecific survivals ranging from 60% to 80% in patients with localized high-grade sarcomas [2,5,27]. Despite this success, the outcomes of patients who have metastatic disease at diagnosis or those with tumors showing a poor response to chemotherapy are still unsatisfactory (5-year disease-specific survival rates, 20%-40%), even with doseintensive or high-dose chemotherapy [9,18,19,33]. For improving the prognosis of patients with these difficult-totreat sarcomas, it is imperative to develop new targeted therapeutic strategies based on an understanding of the biologic mechanisms underlying the metastasis and chemoresistance of these tumors.…”

Histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in clear cell sarcoma models

“…Nevertheless, more than half of patients develop metastases and 5-year disease-specific survival is <50%. No targeted chemotherapies are available and conventional agents offer little benefit (2).…”

Clear Cell Sarcoma of Tendons and Aponeuroses: Presentation of 4 Cases

“…[5][6][7][8][9] İmmünohistokimyasal olarak HMB-45, S-100 ve Melan-A gibi melanoma özgül olanların yanı sıra, NSE, kromogranin gibi nöroendokrin belirleyicilerle de boyanma izlenebilir. [4][5][6][7]9,10 OLGU SUNUMLARI Kasım 2000-Haziran 2010 tarihleri arasında bö-lümümüzde tanı alan 4 adet TABHS olgusu değerlendirilmiştir. Olgularla ilgili yaş, cinsiyet lokalizasyonu, tümör çapı, tedavi şekli gibi klinik parametrelerin yanı sıra histopatolojik özellikler, histokimyasal ve immünohistokimyasal bulgular da araştırılmıştır.…”