Clear cell sarcoma of soft tissue in pleural cavity: A case report

Abstract

BACKGROUNDClear cell sarcoma (CCS) of soft tissue is a rare malignant soft tissue sarcoma usually reported to locate at distal end of extremities and rarely at trunk. Herein, we report a case of CCS in pleural cavity.CASE SUMMARYA 31-year-old male was admitted for an uncertain mass in left pleural cavity in routine physical examination without any symptoms. A VATS surgery was performed to remove the tumor. The pathological finding displayed a cystic mass with 6.5 cm at the longest diameter, dark red in section and cysts could be found locally. A strong expression of S-100, HMB45 and Vimentin was detected in immunohistochemical staining, which was inclined to the diagnosis of the CCS of soft tissue. The patient refused chemotherapy, radiotherapy and targeted therapy because of the personal financial situation. Follow-up computed tomography scans were done at the 90th postoperative day and the 180th postoperative day, and no obvious sign of recurrence was found till now.CONCLUSIONCCS of soft tissue also can be found in pleural cavity although in an extremely rare incidence. Radical resection is useful to improve the prognosis.

CT Radiomics to Differentiate Between Wilms Tumor and Clear Cell Sarcoma of the Kidney in Children

“…CCSK is a rare renal malignancy after nephroblastoma, and its histologic and immunohistologic features are unknown [4] . In clinical presentation, the main symptoms of CCSK are abdominal masses, abdominal pain, hematuria, and other atypical symptoms, and the lack of speci city of these symptoms can lead to preoperative misdiagnosis of wilms tumor [3] .…”

“…Clear cell sarcoma of kidney (CCSK) is a rare renal malignancy that occurs in approximately 2-5% of renal tumors in children, second only to Wilms Tumor (WT), with an age of onset of approximately 2-4 years [1,2] . The incidence of CCSK is low, but bone metastases occur frequently and its prognosis is inferior to that of WT tumors, and the brain is the most prevalent location of late recurrence in ccsk [3,4] . Due to the use of more intense chemotherapy and radiotherapy in recent years, the outcome of CCSK has greatly improved.…”

“…However, biopsy can only capture a small fraction of tumor heterogeneity, usually at a single anatomical sit [8] , and the diversity of CCSK histology, the lack of immunohistological markers, and the ineffectiveness of molecular genetics lead to pathological examinations that do not reveal the biological characteristics with full accuracy [4,9] .In contrast, radiomics can help with tumor detection and differential diagnosis by revealing hidden information that the human eye cannot see and quantifying the pixel distribution of tumors on medical pictures to capture the heterogeneity of the overall tumor volume [10] .In the previous literature, radiomic analysis has been widely used for adult renal tumors [11,12] . Only one study has evaluated the feasibility of texture analysis using grayscale ultrasound images to identify renal malignancies in children [5] .…”

Primary Clear Cell Sarcoma of the Ileum: A Case Report With Next-Generation Sequencing Analysis

“…Clear cell sarcoma of soft tissue (CCS-ST) is a distinctive entity that has a predilection for the distal extremities of young to middle-aged adults. This rare tumor type can also arise in some unusual sites, including the head and neck region, 1,2 pleura, 3,4 trunk, 5 retroperitoneum, 6 penis, 7,8 bone, 9,10 and visceral organs. 11 In 2003, Zambrano et al 12 reported a small series of 6 gastrointestinal (GI) tumors sharing morphological features in common with CCS-ST but showing essential differences, particularly the absence of expression of melanocytic markers or ultrastructural evidence of melanocytic differentiation.…”