2021
DOI: 10.21873/cgp.20265
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Abstract: In order to identify new targets and treatment modalities for clear cell renal carcinoma, we surveyed the literature with respect to microRNAs involved in this disease. In this review, we have focused on up-and down-regulated miRs which mediate efficacy in preclinical clear-cell renal carcinoma-related in vivo models. We have identified 10 upregulated and 33 down-regulated micro-RNAs according to this criterion. As proof-of-concept, micro-RNAs interfering with VEGF (miR-205p) and mTOR (mir-99a) pathways, which… Show more

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Cited by 4 publications
(5 citation statements)
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References 189 publications
(319 reference statements)
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“…Some transcription factors are accumulated due to VHL inactivation, which induces the expression of vascular endothelial growth factor (VEGF). Therefore, ccRCCs are often highly vascularized and respondent to anti-angiogenic therapy (3). Subsequent mutations commonly arise in BAP1/PBRM1/SET2/KDM5C, giving rise to DNA repair defects.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Some transcription factors are accumulated due to VHL inactivation, which induces the expression of vascular endothelial growth factor (VEGF). Therefore, ccRCCs are often highly vascularized and respondent to anti-angiogenic therapy (3). Subsequent mutations commonly arise in BAP1/PBRM1/SET2/KDM5C, giving rise to DNA repair defects.…”
Section: Introductionmentioning
confidence: 99%
“…Alternatively, miRNAs can be associated to the development of tumor-suppressive and oncogenic functions, and their ability to modulate different genes may be also context dependent (3). Specifically, miR-gene regulation may repress or promote transcription (non-canonical) or translation (canonical) (15).…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, recent research has identified targeting the ACE2/Ang-(1-7) axis is a promising therapeutic strategy [ 42 ]. Other studies have discovered new markers, like SPOP (targeted by miR-520,372/373) and CBP (targeted by miR-200a-3p), as a tractable target for the treatment of ccRCC [ 43 ]. ccRCC tumors harbor mutations in the VHL gene, resulting in the loss of oxygen-sensing ability, increasing the stability of hypoxia-inducible factors (HIFs), and thus inducing metabolic reprogramming.…”
Section: Discussionmentioning
confidence: 99%
“…One group of molecules that could be considered as clinical targets in ccRCC are microRNAs (miRNAs) ( 5 , 6 ). These non-coding small RNAs elicit tumor suppressive and oncogenic characteristics by targeting multiple expressed genes in order to alter multiple biological events including cellular proliferation, migration, invasion, epithelial-mesenchymal transition, and cell death events ( 5 , 6 ). Interestingly, in contrast to eukaryotic mRNAs, the clustering and unified transcription of miRNAs is common ( 7 ).…”
Section: Introductionmentioning
confidence: 99%