Clear Cell Hidradenoma of the Breast Diagnosed on a Core Needle Biopsy: A case report and review of the literature

Abstract

Clear cell hidradenoma (CCH) is a tumour originating from the eccrine sweat glands. It usually presents in the limbs, axilla or trunk. CCH of the breast is rare and can present as a cystic lesion in the breast that can be easily misdiagnosed as malignancy. We report a 36-year-old female patient who presented at the Sultan Qaboos University Hospital Breast Clinic, Muscat, Oman, in 2018 with a lump in her left breast. Ultrasound examination reported a complex cystic lesion with a solid, vascular component. An ultrasound-guided core needle biopsy was suggestive of clear cell hidradenoma. Surgical excision was performed and histopathology confirmed the diagnosis of CCH of the breast. This is the first ever case of a diagnosis of CCH made using core needle biopsy. CCH can be challenging to diagnose; therefore, awareness of its histopathological and ultrasonographic features are essential to avoid misdiagnosis and over treatment.Keywords: Eccrine Glands; Breast; Acrospiroma; Sweat Gland Adenoma; Sweat Gland Neoplasms; Case Report; Oman.

Challenging diagnosis of male intraductal papilloma masquerading as eccrine hidradenoma in the breast: Case report

“…[ 8 , 9 ] Breast CCH is rare, and some studies have indicated that it may coexist with both eccrine sweat glands and mammary ducts. [ 10 ] When CCH is situated within the mammary duct, its ultrasound appearance manifests as a cystic lesion within the deep breast tissue. In such cases, the lesion is no longer confined to the skin layers, posing challenges in distinguishing it from intraductal papillomas on ultrasound images.…”

Malignant epithelial neoplasm of adnexal origin: Hidradenocarcinoma of breast: A rare case report

“…The tumor is composed of polyhedral, squamoid, clear, poroid / transitional and rarely mucinous cells. 10 To diagnose malignancy, there should be infiltrative growth pattern, deep extension, nuclear pleomorphism, necrosis, vascular or perineural invasion, Mitosis of 4 or more/ 10 HPF, Ki -67 > 11%, PHH3 > 0.7% reported in malignant cases. 11 Immunohistochemistry studies are usually positive for cytokeratins, CEA, EMA, GCDFP-15 and p63, but negative for vimentin.…”