Clear Cell Hidradenocarcinoma of the Breast: A Very Rare Breast Skin Tumor

Mezzabotta, Maurizio; Declich, Paolo; Cardarelli, Mery; Bellone, Stefano; Riggio, Eliana; Pallino, Antonio

doi:10.1177/030089161209800221

Cited by 6 publications

(7 citation statements)

References 8 publications

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“…The most common location of hidradenoma or hidradenocarcinoma in the breast has been reported to be the nipple and subareolar region[17-21]. There have been reports of circumscribed high-density masses on mammograms and cystic masses with significant solid components or mural nodule on sonogram[7,22,23].…”

Section: Discussionmentioning

confidence: 99%

Malignant sweat gland tumor of breast arising in pre-existing benign tumor: A case report

Woo

Hong

2019

WJCC

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BACKGROUNDSweat glands belong to skin appendages. Sweat gland tumors are uncommon, especially when they occur as malignant tumors in the breast. We report a case of malignant sweat gland tumor of the breast, including imaging and pathological findings.CASE SUMMARYA 47-year-old woman visited our hospital with a non-tender palpable lesion in her left breast. The lesion had not shown changes for 10 years. However, it recently increased in size. Sonography showed a well circumscribed cystic lesion with internal debris and fluid-fluid level. Magnetic resonance imaging showed a well circumscribed oval mass with T1 hyper-intensity compared to muscle and T2 high signal intensity. There was a small enhancing mural component in the inner wall of the mass. The tumor was resected. Its pathologic result was a malignant transformation of benign sweat gland tumor such as hidradenoma. The lesion was treated with excision and radiation therapy. At 1-year follow up, there was no local recurrence or metastasis in the patient.CONCLUSIONIn the case of a rapid growing cystic mass in the nipple and subareola, it is necessary to distinguish it from a malignant sweat gland tumor.

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Section: Discussionmentioning

confidence: 99%

Malignant sweat gland tumor of breast arising in pre-existing benign tumor: A case report

Woo

Hong

2019

WJCC

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“…Malignant forms of clear cell hidradenoma typically arise de novo, but on occasion transform from the benign variant [5]. No features to date have been predictive of aggressive behavior [8].…”

Section: Discussionmentioning

confidence: 99%

“…Malignant variants tend to have an aggressive course with local recurrence around 50% and metastases in 60% of cases. Metastases tend to affect the regional lymph nodes, but can also involve the lung, bone, brain, liver, viscera, and skin [5,8-9]. Distant metastases are indicative of poor prognosis [8-9].…”

Section: Discussionmentioning

confidence: 99%

“…There are reports of using trastuzumab for HER-2 positive tumors as well as hormonal therapy with some anecdotal success. Adjuvant chemotherapy and radiotherapy are not beneficial in local control or survival [3,5-9]. …”

Section: Discussionmentioning

confidence: 99%

“…Accounting for all clear cell carcinomas, that makeup just 1.4% to 3% of all breast tumors. Clear cell hidradenocarcinoma originating from the breast is exceedingly rare with only a few reported cases in the literature [4-5]. The written consent was given by the patient.…”

Section: Introductionmentioning

confidence: 99%

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Malignant Clear Cell Hidradenoma of the Breast

Chambers

Rahal

Reddy

et al. 2017

Cureus

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A 58-year-old female had a mass in the right breast palpable beneath the areola. A mammogram revealed a 1.5-centimeter soft tissue density that was confirmed with a subsequent ultrasound. The patient underwent a core needle biopsy which was initially reported as a moderately differentiated invasive ductal carcinoma. Immunohistochemical analysis revealed negative staining for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor (HER2), mammaglobin, and gross cystic disease fluid protein 15 (GCDFP-15). A wide local excision of the mass was performed. The pathology report stated the tumor had an infiltrative growth pattern with a desmoplastic stromal response with enhanced epithelial atypia consistent with malignant transformation of a nodular clear cell hidradenoma. Clear cell hidradenoma is a very rare tumor originating from the sweat gland and has a propensity for the face and extremities. The malignant variant of this tumor is extremely rare and has been reported to originate from the breast in few cases. This case represents the difficulty in diagnosing this tumor along with the radiographic and histologic features that can distinguish this malignancy from other entities.

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Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature

Singh¹,

Narasimha

Kumar³

et al. 2012

Int Ophthalmol

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Clear cell hidradenocarcinomas are extremely rare neoplasms, with very few well-documented cases reported in the literature. The most common sites are the head and neck regions. These tumors are histologically malignant but are not always aggressive. They are known for recurrence and may metastasize widely. Treatment is wide local resection. We report on a case of clear cell hidradenocarcinoma occurring over the eyelid together with a review of the literature.

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Clear Cell Hidradenocarcinoma of the Breast: A Very Rare Breast Skin Tumor

Cited by 6 publications

References 8 publications

Malignant sweat gland tumor of breast arising in pre-existing benign tumor: A case report

Malignant sweat gland tumor of breast arising in pre-existing benign tumor: A case report

Malignant Clear Cell Hidradenoma of the Breast

Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature

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