Clear cell fibrous papule: report of a case mimicking a balloon cell nevus

Chiang, Yi Chun; Tsai, Hsiou-Hsin; Lee, William R.; Wang, Kuo-Hsien

doi:10.1111/j.1600-0560.2008.01038.x

Cited by 15 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Twenty‐two cases of clear cell fibrous papule have been reported to date (including the granular cell variant) . Like the common angiofibroma, clear cell fibrous papule appears as a dome‐shaped skin‐colored to slightly erythematosus solitary papule, which appears most commonly on the nose of adults.…”

Section: Discussionmentioning

confidence: 99%

Eruptive dermal clear cell desmo‐plastic mesenchymal tumors with perivascular myoid differentiation in a young boy. A clinical, histopathologic, immunohistochemical and electron microscopy study of 17 lesions

et al. 2013

View full text Add to dashboard Cite

Clear cell tumors of the skin are observed in a wide variety of benign and malignant conditions with different histogenesis, sharing the presence of cells with abundant clear cytoplasm. Herein, we report the clinicopathologic features of a healthy young patient affected by asymptomatic, eruptive and disseminated, benign clear cell dermal tumors since early infancy. Neither family history nor genetic testing and counseling provided further useful information. The lesions were mostly confined to the face and lower left extremity with pink teleangiectatic papules and small nodules. Over a 4-year period, a total of 16 different cutaneous lesions were biopsied and histopathologic and immunohistochemical studies carried out; an additional lesion was also removed for electron microscopy examination. Histopathology evidenced multiple perivascular growths of spindle to oval and round cells intermingled with clear/granular cells throughout the dermis, with prominent desmoplasia and numerous capillary-like vessels with focal hemangiopericytoma-like features. Immunohistochemical neoplastic cells were uniformly positive for h-caldesmon and focally smooth muscle α-actin and CD13 indicating myoid differentiation whereas the consistent diffuse cytoplasmic staining for lysosome antigen, such as CD68PG-M1 and NKI/C3 along with the ultrastructural findings supported the view of a lysosome-mediated apoptotic process. The differential diagnosis with other clear cell cutaneous neoplasms is discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

Eruptive dermal clear cell desmo‐plastic mesenchymal tumors with perivascular myoid differentiation in a young boy. A clinical, histopathologic, immunohistochemical and electron microscopy study of 17 lesions

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Hypercellular FP presents as marked fibroblastic proliferation and fibroplasia of spindle to round cells, mimicking atypical fibroxanthoma and melanoma 2 . Clear cell FP, posing as the most difficult variant for definitive histopathological diagnosis, reveals a proliferation of single or small clusters of cells with vacuolated clear cytoplasm, with dilated vessels and spindle/stellate cells in the background 14 . Epithelioid FP reveals large cells with abundant pink cytoplasm and without apparent granules, along with increased numbers of small blood vessels within and around the cellular component 15 .…”

Section: Discussionmentioning

confidence: 99%

Histopathological characteristics and CD163 immunostaining pattern in fibrous papule of the face

et al. 2020

View full text Add to dashboard Cite

Background Signs of inflammation including epidermal interface changes, spongiosis, and dermal inflammation as well as pagetoid dyskeratosis are rarely described in fibrous papule (FP). We aimed to describe the inflammatory parameters, the rate of pagetoid dyskeratosis, along with CD163 immunohistochemical staining as an adjunctive diagnostic tool in FP. Methods Histopathology samples of all biopsy‐proven FP cases were retrieved from archives and investigated for inflammatory parameters, presence of pagetoid dyskeratosis, as well as CD163, CD10, and CD34 immunostaining pattern of dermal spindle/stellate or multinucleate cells (graded from 0 to 4). Results Thirty‐two cases of FP were identified. A high rate of inflammatory parameters including interface changes (20/32), spongiosis (31/32), and dermal lymphocytic inflammation (31/32) were detected. Pagetoid dyskeratosis was identified in eight out of 32 cases (25%). A grade 4 staining revealing a strong dendritic pattern was confirmed in all FP cases with CD163 immunohistochemistry including atypical variants such as granular FP, compared with CD10 (11/32) and CD34 (3/32). Conclusion The dendritic cellular proliferation in FP may represent an inflammatory response to various stimuli; pagetoid dyskeratosis is a relatively common and underrecognized epidermal feature and CD163 immunostaining may be used as an adjunctive diagnostic tool in unusual histopathological subtypes.

show abstract

“…Des variantes ont été décrites à partir des années 1990 sur la base de cas isolés ou de petites séries : la forme à cellules granuleuses [2], la forme à cellules claires [3][4][5][6] et la forme à cellules épithélioïdes [7]. Dans la seule étude de grande ampleur publiée à ce jour, les auteurs ont également identifié d'autres variantes : hypercellulaire, inflammatoire, pigmentée, et enfin à cellules pléomorphes [8].…”

Section: Discussionunclassified

Papules fibreuses du visage : une étude anatomo-clinique rétrospective de 283 cas

Cambourg

Cribier

2013

Annales de Dermatologie et de Vénéréologie

View full text Add to dashboard Cite

Clear cell fibrous papule: report of a case mimicking a balloon cell nevus

Cited by 15 publications

References 12 publications

Eruptive dermal clear cell desmo‐plastic mesenchymal tumors with perivascular myoid differentiation in a young boy. A clinical, histopathologic, immunohistochemical and electron microscopy study of 17 lesions

Eruptive dermal clear cell desmo‐plastic mesenchymal tumors with perivascular myoid differentiation in a young boy. A clinical, histopathologic, immunohistochemical and electron microscopy study of 17 lesions

Histopathological characteristics and CD163 immunostaining pattern in fibrous papule of the face

Papules fibreuses du visage : une étude anatomo-clinique rétrospective de 283 cas

Contact Info

Product

Resources

About