Clear cell chondrosarcoma calcaneum – A case report and review of literature

Singh, Nagmani; John, Rakesh; Aditya, Aggarwal; Patel, Shwetak; Arjun, Rajalakshmi; Gochhait, Debasis

doi:10.1016/j.foot.2014.11.006

Cited by 6 publications

(15 citation statements)

References 14 publications

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“…6 Other reported sites of involvement include the proximal humerus, distal femur, proximal tibia, vertebrae, ribs, skull, maxilla, ischium, ulna, calcaneum, scapula, and phalanx. [6][7][8][9][10][11] Radiographically, these tumors present as lytic epiphyseal lesions, often with a sclerotic border. 11,12 Cortical destruction tends to be unusual.…”

Section: Cytologic Findingsmentioning

confidence: 99%

“…1,2 Importantly, none of these cases represented the rendering of a primary diagnosis of CCCS via FNA, but instead are a mixture of local recurrences and metastases diagnosed via fine needle-aspiration (FNA) or touch preparation (TP) cytology material. [6][7][8][9][10][11] Radiographically, these tumors present as lytic epiphyseal lesions, often with a sclerotic border. 3 Herein, we describe a single case of CCCS with primary diagnosis rendered on FNA cytology with concurrent core needle biopsy (CNB) and confirmed on subsequent surgical resection.…”

Section: Introductionmentioning

confidence: 99%

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Fine needle aspiration biopsy diagnosis of primary clear cell chondrosarcoma: A case report

McHugh

Emory

Parks

et al. 2017

Diagnostic Cytopathology

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Clear cell chondrosarcoma is a rare chondrosarcoma variant often involving the long bone epiphyses of young to middle aged adults. We report herein a case involving the left femoral head in a 25-year-old female with a 3-month history of worsening left hip pain. Radiographs revealed a complex, multifocal and lytic lesion centered in the left proximal femoral epiphysis with involvement of the femoral neck. Computed tomography-guided fine needle aspiration biopsy with concomitant core needle biopsy was performed, and a diagnosis of clear cell chondrosarcoma was rendered. Cytologic smears revealed aggregates of matrix material accompanied by a population of mostly uniform spindled to epithelioid and histiocytoid cells, rarely accompanied by osteoclast-type giant cells. The patient underwent surgical resection with -total hip replacement, and subsequent pathologic examination confirmed the initial needle biopsy diagnosis. There has been no evidence of local recurrence or distant metastases with 3-years follow-up. To our knowledge, this is the first reported example of a primary clear cell chondrosarcoma initially evaluated by fine needle aspiration biopsy.

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Section: Cytologic Findingsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fine needle aspiration biopsy diagnosis of primary clear cell chondrosarcoma: A case report

McHugh

Emory

Parks

et al. 2017

Diagnostic Cytopathology

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“…1F ) include deep endosteal scalloping with bone expansion, cortical destruction, endosteal erosion, matrix calcification, periosteal reaction and pathologic fracture ( 102 – 107 ). CT of the calcaneus has been more accurate in the detection of soft tissue extension, calcification and cortical involvement ( 105 ). Using MRI, a well-defined lobulated mass with a low signal intensity may be observed on the T1-weighted image and a high signal intensity on the T2-weighted image with multiple septations, reflecting the high water content of this cartilaginous neoplasm ( 106 , 107 ).…”

Section: Malignant Calcaneal Tumour Typesmentioning

confidence: 99%

“…On BSs, there is increased tracer uptake in the lesion. BS and chest X-ray/CT must be performed routinely to rule out metastasis even in the absence of clinical symptoms ( 105 ).…”

Section: Malignant Calcaneal Tumour Typesmentioning

confidence: 99%

“…Microscopy may reveal numerous pleomorphic chondrocytes with hypercellularity and cytologic atypia. An abundant foamy to clear cytoplasm is a feature of clear cell chondrosarcoma ( 105 ). With the use of immunohistochemistry, the tumour cells are positive for S-100 proteins and negative for cytokeratin and CD68 ( 104 – 106 ).…”

Section: Malignant Calcaneal Tumour Typesmentioning

confidence: 99%

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Primary tumours of the calcaneus (Review)

et al. 2018

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The calcaneus is a rare location for the occurrence and development of primary tumour types. Clinicians are unfamiliar with calcaneal tumour types, which may result in a delay in diagnosis or a missed diagnosis, resulting in unnecessary morbidity and amputation. Heel pain and localized swelling of the ankle are the most common symptoms. X-ray is the first choice for a tentative diagnosis of a calcaneal tumour. The final diagnosis depends on a histological examination. The treatment of calcaneal tumour types varies depending on the Enneking system. The majority of patients with benign tumours heal, except for a few with a palindromia. For malignant tumours, the prognosis is comparatively poor, resulting in disability and a high rate of metastasis. This review describes the spectrum of calcaneal tumour types and specifically illustrates the epidemiology, symptomatology, imagology, histopathology and treatment options that may facilitate diagnosis and improve prognosis.

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Diagnoses, treatment, and oncologic outcomes in patients with calcaneal malignances: Case series, systematic literature review, and pooled cohort analysis

Newman

Rein

Theyskens

et al. 2020

Journal of Surgical Oncology

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Background and Objectives: Malignant tumors of the calcaneus are rare but pose a treatment challenge. Aims: (1) describe the demographics of calcaneal malignancies in a large cohort; (2) describe survival after amputation versus limb-salvage surgery for high-grade tumors. Methods: Study group: a "pooled" cohort of patients with primary calcaneal malignancies treated at two cancer centers (1984−2015) and systematic literature review. Kaplan−Meier analyses described survival across treatment and diagnostic groups; proportional hazards modeling assessed mortality after amputation versus limb salvage. Results: A total of 131 patients (11 treated at our centers and 120 patients from 53 published studies) with a median 36-month follow-up were included. Diagnoses included Ewing sarcoma (41%), osteosarcoma (30%), and chondrosarcoma (17%); 5-year survival rates were 43%, 73% (70%, high grade only), and 84% (60%, high grade only), respectively. Treatment involved amputation in 52%, limb salvage in 27%, and no surgery in 21%. There was no difference in mortality following limb salvage surgery (vs. amputation) for high-grade tumors (HR 0.38; 95% CI 0.14−1.05), after adjusting for Ewing sarcoma diagnosis (HR 5.15; 95% CI 1.55−17.14), metastatic disease at diagnosis (HR 3.88; 95% CI 1.29−11.64), and age (per-year HR 1.04; 95% CI 1.02−1.07). Conclusions: Limb salvage is oncologically-feasible for calcaneal malignancies.

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Clear cell chondrosarcoma calcaneum – A case report and review of literature

Cited by 6 publications

References 14 publications

Fine needle aspiration biopsy diagnosis of primary clear cell chondrosarcoma: A case report

Fine needle aspiration biopsy diagnosis of primary clear cell chondrosarcoma: A case report

Primary tumours of the calcaneus (Review)

Diagnoses, treatment, and oncologic outcomes in patients with calcaneal malignances: Case series, systematic literature review, and pooled cohort analysis

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