Clear-cell carcinoma originating from cesarean section scar: two case reports 

Abstract

Background Clear-cell carcinoma arising from the surgical cesarean section scar is very infrequent. The present study reports two patients with clear-cell carcinoma arising from an abdominal wall scar 20 and 23 years after their last cesarean section. Case presentation Both Iranian patients had prior cesarean sections nearly 20 years earlier. Patients 1 and 2 had transverse and vertical abdominal incisions, respectively. The initial clinical presentation was a huge lower abdominal mass at the site of the previous cesarean section scar. Both patients underwent abdominal wall mass biopsy. The histological analysis revealed the presence of malignancy. Both patients underwent full-thickness resection of the abdominal wall mass. All surgical margins were tumor-free; however, patient 1 had a very narrow tumor-free margin near the pubic symphysis. As the imaging report of patient 2 revealed the presence of a pelvic mass, the exploration of the intraperitoneal space, simple total abdominal hysterectomy (TAH), bilateral salpingo-oophorectomy (BSO), and the excision of enlarged pelvic lymph nodes were performed during the surgery. Six cycles of paclitaxel and carboplatin every 3 weeks as adjuvant chemotherapy was administered for both patients after the surgery. One of the patients had disease recurrence 5 months after the termination of chemotherapy, and the other is still disease-free. These two patients had similar pathology and received a similar initial adjuvant treatment; however, they were different in terms of the direction of tumor spread, tumor distance from the pubic symphysis, status of tumor margins, and surgical procedures. Conclusions We encountered distinct prognoses in the clear-cell carcinoma of cesarean section scars presented herein. The researchers can recommend complete surgical excision of the abdominal wall mass with wide tumor-free margins, exploration of the abdominopelvic space, TAH, and BSO during the first surgery.

Primary clear cell carcinoma of the vulva: A case report

“…The occurrence of endometriosis implants in surgical incisions is well-established in the literature, and cesarean scar endometriosis is the most common site of abdominal wall endometriosis ( Zhang et al, 2019 ). While CCC arising from abdominal incisions is rare, it has also been documented in the literature—and most commonly associated with prior cesarean section ( Hashemi et al, 2021 ). While there was no background endometriosis observed in any of the tumor specimen sent for pathologic evaluation, it is highly plausible that the tumor destroyed the endometriotic implant from which it arose.…”

Correction to: Clear-cell carcinoma originating from cesarean section scar: two case reports

“…Following publication of the original article [ 1 ], the authors identified an error in the author name of Arezoo Esmailzadeh.…”