Clear Cell Carcinoma of the Ovary Diagnosed in Ascitic Fluid

Vera-Alvarez, J; García-Prats, María Dolores; Marigil-Gómez, Miguel; Abascal-Agorreta, Manuel; López-López, José Ignacio; Ramón-Cajal, José Manuel

doi:10.1159/000325696

Cited by 5 publications

(8 citation statements)

References 16 publications

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“…7,8,[14][15][16] In cytology specimens of CCC, large polyhedral tumor cells occasionally showing a "hobnail" appearance form papillary structures and protrude from the periphery of cell clusters. 7,8,[14][15][16] In cytology specimens of CCC, large polyhedral tumor cells occasionally showing a "hobnail" appearance form papillary structures and protrude from the periphery of cell clusters.…”

Section: Discussionmentioning

confidence: 99%

“…7,8,[14][15][16] In cytology specimens of CCC, large polyhedral tumor cells occasionally showing a "hobnail" appearance form papillary structures and protrude from the periphery of cell clusters. 7,8,[13][14][15]17 They are referred to as "mirror balls" 7 or "raspberry bodies" 8 and considered a hallmark of CCC. 7,8,[13][14][15]17 They are referred to as "mirror balls" 7 or "raspberry bodies" 8 and considered a hallmark of CCC.…”

Section: Discussionmentioning

confidence: 99%

“…Cytological findings of classical ovarian CCC have been reported by several investigators. 7,8,[14][15][16] In cytology specimens of CCC, large polyhedral tumor cells occasionally showing a "hobnail" appearance form papillary structures and protrude from the periphery of cell clusters. [14][15][16] The hyaline stroma is found as globular masses within cell clusters and often seen as free bodies floating in the cystic or peritoneal cavity.…”

Section: Discussionmentioning

confidence: 99%

“…[14][15][16] The hyaline stroma is found as globular masses within cell clusters and often seen as free bodies floating in the cystic or peritoneal cavity. 7,8,[13][14][15]17 They are referred to as "mirror balls" 7 or "raspberry bodies" 8 and considered a hallmark of CCC. However, it is suggested that in this subtype of ovarian CCC with inflammatory stroma, these cytologically diagnostic structures are absent or encountered only rarely, because the tumor usually lacks the papillary growth of "hobnail" cells lining the hyaline or mucoid stroma.…”

Section: Discussionmentioning

confidence: 99%

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Ovarian clear cell carcinoma with plasma cell‐rich inflammatory stroma

Shintaku

Dohi

Yamamoto

et al. 2016

Diagnostic Cytopathology

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We report a case of clear cell carcinoma (CCC) of the ovary with plasma cell-rich inflammatory stroma, a recently proposed subtype of CCC, and present the cytological findings. The patient was a 48-year-old woman, who was incidentally found to have a right ovarian tumor during the preoperative work-up for an early-stage adenocarcinoma of the uterine cervix. Cytological examination of an imprint smear of the ovarian tumor and peritoneal washing revealed solid cell clusters of irregular, often dendritic shapes, which were intermingled with many inflammatory cells. "Raspberry bodies" were not found. Histopathological examination of the extirpated ovarian tumor showed the features of CCC with plasma cell-rich inflammatory stroma. This subtype of ovarian CCC poses cytological and histological diagnostic problems, and its differentiation from dysgerminoma is often difficult, because it mostly lacks the hyaline or mucoid stroma. Irregularly shaped clusters of large polyhedral cells, coarsely clumped nuclear chromatin, and plasma cell-rich inflammatory infiltrates suggest CCC, but the cytological differences between dysgerminoma and CCC are often subtle, and immunohistochemical examinations for cytokeratin 7 or epithelial membrane antigen may be necessary. Diagn. Cytopathol. 2017;45:128-132. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

“…7,8,[14][15][16] In cytology specimens of CCC, large polyhedral tumor cells occasionally showing a "hobnail" appearance form papillary structures and protrude from the periphery of cell clusters. 7,8,[13][14][15]17 They are referred to as "mirror balls" 7 or "raspberry bodies" 8 and considered a hallmark of CCC. 7,8,[13][14][15]17 They are referred to as "mirror balls" 7 or "raspberry bodies" 8 and considered a hallmark of CCC.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Ovarian clear cell carcinoma with plasma cell‐rich inflammatory stroma

Shintaku

Dohi

Yamamoto

et al. 2016

Diagnostic Cytopathology

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“…OCCC represent about 5–10% of all ovarian malignancies in Western populations and up to 25% of all ovarian carcinomas in East Asian populations. Compared with the more common serous carcinomas of the ovary, OCCC affect younger women (mean age 50–55), present at an earlier stage (frequently stage I), are frequently unilateral, are associated with endometriosis and may be complicated by thromboembolic manifestations and paraneoplastic hypercalcemia . OCCC were first described in 1939 by Dr. Walter Schiller, under the name Mesonephroma ovarii , since he believed that they are of mesonephric (Wolffian) rather than Müllerian derivation.…”

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confidence: 99%