Clear-cell carcinoma of the ovary.A clinicopathologic analysis of pure and mixed forms and comparison with endometrioid carcinoma

Czernobilsky, Bernard; Silverman, Barney B.; Enterline, Horatio T.

doi:10.1002/1097-0142(197004)25:4<762::aid-cncr2820250404>3.0.co;2-3

Cited by 88 publications

(19 citation statements)

References 15 publications

(3 reference statements)

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“…1 It is often associated with endometriosis, and nulliparity is frequently described. 2,3 The incidence of CCC varies from 4% to 12% of all ovarian cancers. These tumors were first described by Pelham in 1899 as hypernephroma of the ovary in view of their resemblance to renal cell carcinoma.…”

mentioning

confidence: 99%

Clear Cell Carcinoma Compared to Serous Carcinoma in Early Ovarian Cancer: Same Prognosis in a Large Randomized Trial

Timmers

Zwinderman

Teodorović

et al. 2009

Int J Gynecol Cancer

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mentioning

confidence: 99%

Clear Cell Carcinoma Compared to Serous Carcinoma in Early Ovarian Cancer: Same Prognosis in a Large Randomized Trial

Timmers

Zwinderman

Teodorović

et al. 2009

Int J Gynecol Cancer

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“…To further complicate matters, the distinction between clear cell and endometrioid tumors with areas of cytoplasmic clearing is problematic, and, although true mixed endometrioid and clear cell tumors exist, the point at which a tumor stops being an endometrioid tumor with cytoplasmic clearing and becomes a true mixed endometrioid and clear cell carcinoma is underspecified in the diagnostic pathology literature. 2,4,5,14 Our data demonstrate that the application of uniform histologic criteria defines groups of endometriosisassociated ovarian cancer with significantly different age at presentation, FIGO stage, incidence of simultaneous primary disease, and outcome. Moreover, the linkage with endometriosis differs significantly among the groups.…”

Section: Discussionmentioning

confidence: 61%

Endometriosis Does Not Confer Improved Prognosis in Ovarian Carcinoma of Uniform Cell Type

Cuff

Longacre²

2012

American Journal of Surgical Pathology

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The role of endometriosis in ovarian cancer, disease progression, and survival is a subject of active investigation. A series of 144 ovarian cancers with clear cell or endometrioid histology or associated endometriosis, all classified on the basis of strict histologic criteria, was evaluated to further explore the relationship between endometriosis-associated ovarian cancer and age at presentation, FIGO stage, histology, presence of synchronous primary disease elsewhere in the mullerian tract, and survival. Patients with endometrioid carcinomas were significantly younger (mean, 52 y) in comparison with patients with either clear cell carcinoma (mean, 55 y) or mixed tumors (mean, 59 y; P=0.002). Clear cell carcinoma presented as low-stage disease (FIGO I) in 33% of cases compared with endometrioid carcinomas in 97% of cases and mixed carcinomas in 27% of cases. Endometriosis was associated with 53% of clear cell carcinomas, 33% of endometrioid carcinomas, and 45% of mixed tumors (P<0.001). Synchronous primary tumors, observed in 31% of endometrioid tumors, 5% of mixed tumors, and in 2% of clear cell tumors (P<0.001), were unlikely to be associated with endometriosis (P=0.04). Univariate analysis of the aggregate cohort demonstrated that the single best overall predictor of disease-free survival was FIGO stage at presentation (P<0.001), followed by histologic subtype (P=0.003). Endometriosis did not have a significant relationship with disease-free survival (P=0.7). We conclude that the link between endometriosis and ovarian cancer is much stronger for clear cell carcinoma than for other histologic subtypes (P<0.001). Furthermore, when uniform histologic criteria are applied, true mixed endometrioid and clear cell carcinomas are uncommon; most endometriosis-associated mixed tumors are heterogenous mixtures of endometrioid, mucinous, and serous histology with areas of clear cell cytoplasm. Endometriosis per se does not appear to predict prognosis in clear cell and endometrioid tumors, with the possible exception of tumors with mixed histology. Until more data are collected, pathologists should classify ovarian tumors with mixed histology as a separate and potentially unique biological and prognostic group.

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“…A recent review of " Mesonephromas " of the clear cell type or those with a characteristic tubular pattern (Scully and Barlow, 1967) has given considerable plausibility to the concept that these represent a variant of endometrioid carcinoma and their existence as a distinct entity has also been disputed by Stowe (1955) Willis (1967). In any event other series (Parker, Dockerty and Randall, 1960;Novak and Woodruff, 1959;Czernobilsky, Silverman and Enterline, 1970) suggest that their behaviour is that of serous carcinomas.…”

Section: Methodsmentioning

confidence: 90%

Factors Influencing Survival in Carcinoma of the Ovary

Dyson¹,

Beilby²,

Steele³

1971

Br J Cancer

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SUMMARY.-Three hundred and nineteen patients with primary adenocarcinoma of the ovary were studied to define those factors, many of them histopathological, which influence survival. The paper considers the stage of spread at the time of operation, the histological type of the tumour, its grade and in particular its mitotic activity, which proved a significant feature per se in assessing prognosis in ovarian cancer.A SURVEY has been carred out on 319 patients with primary adenocarcinoma of the ovary to evaluate some of the factors which influence survival in this disease. It became apparent during the investigation that the mitotic count was of considerable prognostic significance. Other factors considered were the histological type of the tumour, the stage to which it had spread at the time of operation and its histological grade. Ford (1928) was the first person to evaluate the prognosis according to the stage of spread at the time of operation, and the first large series was published in 1932 (Heyman, 1932). The first paper on grading appeqred at much the same time (Taylor, 1929), and most series since that of Pemberton (1940) have treated it as an important prognostic factor.Although cellular atypicality, as a feature of malignancy, has been discussed frequently in relation to grading, mitotic activity has received much less attention. Barzilai (1943) reported that mitoses were "frequently seen " in the group of tumours which she called " sero-anaplastic", and Allan and Hertig (1949) used profusion of mitoses as one of the indicators of the most malignant neoplasms. But at the time when this study was undertaken, no publication had been found in which mitoses were considered as a separate feature. The only published work specifically devoted to this point was by Novak and Woodruff (1967) after the present investigation had been largely completed. It confirms that the count of mitoses per high power field is of prognostic significance in carcinoma of the ovary.

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Clear-cell carcinoma of the ovary.A clinicopathologic analysis of pure and mixed forms and comparison with endometrioid carcinoma

Cited by 88 publications

References 15 publications

Clear Cell Carcinoma Compared to Serous Carcinoma in Early Ovarian Cancer: Same Prognosis in a Large Randomized Trial

Clear Cell Carcinoma Compared to Serous Carcinoma in Early Ovarian Cancer: Same Prognosis in a Large Randomized Trial

Endometriosis Does Not Confer Improved Prognosis in Ovarian Carcinoma of Uniform Cell Type

Factors Influencing Survival in Carcinoma of the Ovary

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