Clear-Cell Carcinoma of the Ovary with Bilateral Breast Metastases

Galili, Yehuda; Lytle, Meghan; Bartolomei, Jonathan; Amandeep, Kataria; Allen, Nichole; Carlan, S. J.; Madruga, Mario

doi:10.1155/2019/8013913

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Risk factors include early menarche, late menopause, nulliparity, infertility, BRCA1 and BRCA2 (breast cancer 1 and 2 gene) mutations, as well as Lynch syndrome. [3] In 1973, the World Health Organization (WHO) strictly defined ovarian clear cell carcinomas (OCCCs) as lesions characterized by clear cells growing in solid, tubular or glandular patterns with hobnail cells lining tubules and cysts. Subsequently, it was observed that Schiller's original descriptions actually included two distinct populations: a highly malignant germ cell tumor occurring in younger women, and another tumor of epithelial origin with a less aggressive phenotype,…”

Section: Introductionmentioning

confidence: 99%

Clear Cell Carcinoma of Ovary: A Rare Case Report

Rajput,

Maheshwari,

Ahmed

et al. 2023

Ann of Pathol and Lab Med

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Ovarian cancer is a heterogeneous disease and is morphologically divided into six types of epithelial ovarian tumors -serous, mucinous, endometrioid, brenner, clear cell and undifferentiated carcinoma. Clear cell carcinoma (CCC) represents 2-10% of all epithelial ovarian cancers. The median age of presentation is between 40 to 70 years with peak incidence at 52 yrs. We present a case of 25-year unmarried female who presented with complaints of polymenorrhagia and abdominal distension for past 3 months. Ultrasound of abdomen revealed complex mass with solid component seen in the left adnexal region measuring 15x12x10 cm. CT scan showed left sided adnexal cystic mass with solid mural component with thick internal septation. Imprint smear from Left ovary, showed singly scattered and clusters of cells with round to oval vesicular nuclei and scant amount of eosinophilic cytoplasm. Background showed cystic macrophages, mixed inflammatory infiltrate and hemorrhage, suggestive of a serous tumour. On gross examination, of left ovary a globular solid cystic mass measuring 15x12x6 cm was received. On microscopic examination, tumor cells were arranged in small sheets, glands and tubules separated by fibrous stroma. These were lined by clear and hobnail cells. The cells were cuboidal to columnar with abundant clear cytoplasm and eccentric nucleus. Immunohistochemistry showed EMA and PanCK positivity. Overall morphology and IHC favored a diagnosis of Clear cell carcinoma of left ovary. The tumor was graded as pT2bN0Mx. The patient was followed up postoperatively. CA-125 returned to normal levels during follow-up.

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Section: Introductionmentioning

confidence: 99%

Clear Cell Carcinoma of Ovary: A Rare Case Report

Rajput,

Maheshwari,

Ahmed

et al. 2023

Ann of Pathol and Lab Med

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“…Ovarian cancer is the fifth most frequent diagnosis of female malignancy and the second most common female gynecologic malignancy after breast cancer [1,2]. The 5-year prevalence is 213 cases per million with 2.1 percent deaths as per GLOBOCON 2020 data [3].…”

Section: Introductionmentioning

confidence: 99%

Breast Metastases from Ovarian Primary: A Rare Entity and Review of Literature

Singh¹,

Bhushan²,

Kumar³

et al. 2021

Int J Oncol Res

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Ovarian Cancer Metastasis to the Breast: A Case Report and Review of the Literature

et al. 2020

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Although ovarian cancer often presents as a widespread disease, metastases to the breast and/or axillary lymph nodes are a very rare event, accounting for only 0.03–0.6% of all breast cancers. Its early recognition and accurate distinction from primary breast cancer are of crucial importance to choose an adequate systemic therapy over unnecessary surgeries. We presented the case of a 53-year-old woman who was diagnosed with breast metastases 2 years after the diagnosis of advanced primary serous ovarian cancer. The patient underwent primary cytoreductive surgery and platinum-based chemotherapy in combination with bevacizumab, followed by bevacizumab maintenance for 18 months. After 2 years of negative follow-ups, the disease unexpectedly spread to the left breast and axillary lymph nodes. No axillary lymph node dissection or breast surgery was performed. The patient received axillary radiotherapy and multiple chemotherapy lines: gemcitabine/cisplatin, liposomal doxorubicin, topotecan, olaparib/cediranib, paclitaxel, and cisplatin. Unfortunately, none of these treatments improved her prognosis and she died 3 years after the disease recurrence. Ovarian cancer metastasis to the breast reveals a disseminated disease with a poor prognosis. Currently, no valid treatment options are available as the disease shows multidrug chemoresistance. In the era of precision medicine, the characterization of genetic and molecular markers may play a role in offering new promising targeted therapies.

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Clear-Cell Carcinoma of the Ovary with Bilateral Breast Metastases

Cited by 3 publications

References 18 publications

Clear Cell Carcinoma of Ovary: A Rare Case Report

Clear Cell Carcinoma of Ovary: A Rare Case Report

Breast Metastases from Ovarian Primary: A Rare Entity and Review of Literature

Ovarian Cancer Metastasis to the Breast: A Case Report and Review of the Literature

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