Clear cell carcinoma of the lung

Kitada, Masahiro; Ozawa, Keisuke; Sato, Kazuhiro; Hayashi, Satoshi; Miyokawa, Naoyuki; Sasajima, Tadahiro

doi:10.1007/s11748-009-0471-8

Cited by 12 publications

(12 citation statements)

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“…These tumor cells showed immunoreactivity for human melanoma black (HMB-45) and S-100, with no reactivity for cytokeratin 7 or epithelial membrane antigen. 7,8 They are also positive for tyrosinase, melan-A, microphthalmia transcription factor, and NKI/C3. The most sensitive markers being HMB-45, melan-A, and microphthalmia transcription factor.…”

Section: Discussionmentioning

confidence: 99%

“…5 Another leading differential is a clear cell pulmonary carcinoma. 7,8 This type will have abundant mitosis, necrosis, and reactivity to cytokeratin. However, benign sugar tumors of the lung, in general, have shown no evidence of reoccurrence, extensive tissue invasion, or metastasis, even after enucleation.…”

Section: Discussionmentioning

confidence: 99%

“…This vascularity lends support to the tumor being primary in the lung and not a metastasis. 7 The question about the tumor's malignancy brings up an interesting discussion about this tumor and its resultant PET scan. Studies with PET of lung tumors have shown that the prevalence of malignancy in solitary pulmonary nodules increases to about 64 to 82% for masses greater than 2 cm.…”

Section: Discussionmentioning

confidence: 99%

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Clear Cell “Sugar” Tumor of the Lung: Benign or Malignant?

Olivencia‐Yurvati

Rodriguez

2015

International Surgery

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Clear cell ''sugar'' tumors of the lung are rare pulmonary tumors. This case study illustrates a patient who was found to have a persistent nodule in the left-upper lobe of the lung. Positron emission tomographic scanning showed mild-moderate 18-fluorodeoxyglucose uptake. Based on these findings, a video-assisted resection of the tumor was undertaken. The mass was identified histologically, as a clear cell ''sugar'' tumor of the lung. This case report discusses the benign versus malignant nature of this rare tumor.Key words: Clear cell sugar tumor -Rare tumor -Lung tumor -Incidentaloma L ung cancer is one of the leading causes of cancer death in industrialized countries. Early discovery is an important factor for survivability. With only a limited number of cases reported, 1 clear cell (sugar) lung tumors are extraordinarily rare. These particular lung tumors have been described as benign neoplasms that have a considerable amount of intracellular glycogen among other diagnostic features. The characteristic presence of such a high amount of glycogen has led to these tumors as often being referred to as simply, sugar tumors of the lung. The purpose of this report is to add to other reported cases of this rare pulmonary lesion, through a comprehensive literature review. The goals are to inform physicians of this rare entity, and to discuss how these tumors can be confused with malignant tumors. CaseA 39-year-old, well-developed female presented with evidence of a persistent nodule located in the left-upper lobe of the lung. A whole body positron emission tomographic/computed tomography (PET/CT) showed the nodule measuring approximately 1.1 cm 3 1.0 cm in size along with persistent ground glass type infiltrate. The 18-fluorodeoxyglucose uptake was positive. The nodule was also shown to be changing with serial films, with an increase in size. The structural exam was normal except for paravertebral tissue fullness around T2 to T5. It was recommended that she undergo videoassisted thoracoscopic resection of the lesion. A wedge resection was carried out and the lesion was successfully removed alongside normal surrounding parenchyma. Frozen sections showed evidence of inflammatory cells surrounding the nodule, but no evidence of malignancy. During the operation, both the lesion and the lung parenchyma were opened and aerobic, anaerobic, and acid-fast cultures were obtained. The rest of the lung appeared healthy with no pleural effusions or any other abnormalities. The operation was well-tolerated and the patient recovered completely and continued to do well on postsurgical cardiothoracic surgical clinic visits. Final pathology was consistent with benign sugar tumor (Fig.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clear Cell “Sugar” Tumor of the Lung: Benign or Malignant?

Olivencia‐Yurvati

Rodriguez

2015

International Surgery

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“…Primary clear cell adenocarcinoma is extremely rare; only several cases have been reported in the English literature [2][3][4][5]. Herein reported is a primary clear cell adenocarcinoma of the lung.…”

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confidence: 88%

Primary clear cell adenocarcinoma of the lung

Terada

2010

Med Oncol

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Primary clear cell adenocarcinoma of the lung is extremely rare. A 63-year-old Japanese man consulted to our hospital because of cough and sputum. Imaging modalities including XP, CT and MRI revealed a tumor of the right middle lobe. They did not identify other tumors in the body. Because clinical cytology and biopsy showed malignant cells, segmentectomy of the lobe was performed. Grossly, the tumor was whitish tan tumor measuring 5 × 6 × 5 cm. Histologically, the tumor was composed entirely of clear cells arranged in papillary and tubular patterns. The tumor cells had hyperchromatic nuclei, and mitotic figure and nuclear stratification were scattered. Histochemically, glycogen and mucins were absent in tumor cell cytoplasm. Immunohistochemically, the tumor cells were positive for pancytokeratin (AE1/3, CAM5.2), cytokeratin (CK) 7, CK 8, CK18, CK19, EMA, CEA, CA19-9, CA125, p53, Ki-67 (labeling = 80%), TTF-1 and surfactant apoprotein A. In contrast, the tumor cells were negative for CK5/6, CK 34βE12, CK 14, CK 20, vimentin, desmin, S100 protein, α-smooth muscle actin, AFP, HMB45, CD10, CD34, HER2/neu, CD56, p63, and synaptophysin. The tumor recurred 6 months after the operation, and right middle lobectomy was performed. Postoperative imaging modalities showed no tumors. The patient is alive free from tumor 9 years after the first manifestation.

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“…Literatürde primer akciğer BHK ile ilgili nadir olgu bildirimleri vardır (2). Dünya sağlık örgütü akciğer kanseri sınıflamasında BHK; adenokarsinom, yassı hücreli karsinom ve büyük hücreli karsinomun bir varyantı olarak sınıflandırılmaktadır (3).…”

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