Clear cell carcinoma of the mandibular gingiva ‘minor salivary gland’: a case report with immunohistochemical study

Suzuki, Hiroyuki; Yamauchi, Genki; Hashimoto, Kenji

doi:10.1016/j.tripleo.2005.11.027

Cited by 21 publications

(8 citation statements)

References 8 publications

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“…Of 153 patients with some form of clinical data reported or available, 144 underwent primary surgical resection. Lymph node dissection was reported in 26 cases, with positive nodes in 13 . Neck dissection, where specified, was usually unilateral, and limited to supraomohyoid levels I to III.…”

Section: Resultsmentioning

confidence: 99%

“…Historical case reports and series emphasized the absence of mucocytes and negative mucicarmine staining in HCCC, [9][10][11]16,19,21,22,27,28,39,43,46,48,[55][56][57][58][59][60] despite the presence of mucin-positive neoplastic cells in the Milchgrub et al 1 initial series. Mucocytes, focal ductal differentiation, presence of cystic spaces, and even rare foci of keratinization are now reported to be features of EWSR1-rearranged HCCC.…”

Section: Discussionmentioning

confidence: 99%

“…Lymph node dissection was reported in 26 cases, with positive nodes in 13. 1,5,8,10,16,22,23,32,[34][35][36][37][38][39] Neck dissection, where specified, was usually unilateral, and limited to supraomohyoid levels I to III. Adjuvant or neoadjuvant therapy was performed in 26 cases, including 8 patients who had also undergone lymph node dissection.…”

Section: Clear Cell Carcinoma -Treatment and Outcomesmentioning

confidence: 99%

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Reappraising hyalinizing clear cell carcinoma: A population‐based study with molecular confirmation

et al. 2016

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Clear Cell Carcinoma -Treatment and Outcomesmentioning

confidence: 99%

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Reappraising hyalinizing clear cell carcinoma: A population‐based study with molecular confirmation

et al. 2016

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“…[31] The diagnostic term "clear cell carcinoma" is a diagnosis of exclusion, applied only after other specific tumors with clear cell morphology are excluded. [32] In the differential diagnosis among different clear cell tumors, histology is often of little use mainly when no definitive evidence of myoepithelial differentiation is found due to the high morphological similarities observed in the different "clear cell" entities. So, immunohistochemistry may be helpful in revealing the cell of origin of the tumor.…”

Section: Discussionmentioning

confidence: 99%

Myoepithelial Cell and Its Prospective Role in Some Salivary Gland Tumors (An Immunohistochemical Study)

Gaafar

Dameer

Khalil

2017

Egyptian Dental Journal

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Salivary gland tumors are characterized by a wide variety of histological types which makes their classification and diagnosis difficult. It should be noted that the diversity in the occurrence and dilemma regarding the pathogenesis of salivary gland tumors is due to lack in distinguishing the cells participating in its oncogenesis, especially the Myoepithelial cells (MECs). MECs are normal constituent of the major and minor salivary glands, they are found between the basal lamina and the acinar or ductal cells. Proper and extensive studies regarding MECs are varied and thus have posed difficulty for a pathologist to understand this cell. Numerous functions of MECs have been described, the most important of them being important for contraction of the glands, also, it has been found to prevent tumor progression. In this study we try to make a thorough description of this cell and its role in some salivary gland tumors. 24 formalin-fixed, paraffin-embedded specimens of salivary gland tumors (7 cases of pleomorphic adenoma, 6 cases of mucoepidermoid carcinoma, 6 cases of Adenoid cystic carcinoma, and 5 cases of clear cell carcinoma) were used in this study.The specimens were cut at 5μm thick for H&E staining as a routine stain and calponin immunostaining. Calponin is a 34 kDa protein, it is a family of actin filament-associated proteins and it is a sensitive immunohistochemical marker for MECs. The present study revealed positive staining reaction for calponin in pleomorphic adenoma and adenoid cystic carcinoma and negative calponin reaction in mucoepidermoid carcinoma and clear cell carcinoma. These findings demonstrate that myoepithelial cells play a role in the pathogenesis of some salivary gland neoplasms and no or minimal role in others.

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“…8 Reconstruction of the surgical defect may be done by microvascular radial forearm fascioucutaneous free-flap or basic hard palate prosthesis. 6 Regarding the rarity of HCCC-reported only 34 cases in the English literature, [1][2][3][4][5][6][7][8][9] and appearing of the clear cells in most of the head and neck tumors, the differential diagnosis of HCCC should be made accurately by the use of clinic, radiologic, histopathologic and immunohistochemical studies.…”

Section: Case Reportmentioning

confidence: 99%

Hyalinizing Clear Cell Adenocarcinoma of the Hard Palate: Case Report

Akyıldız¹,

Kaptan²,

Karadaş³

et al. 2015

Turkiye Klinikleri J Case Rep

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yalinizing clear cell carcinoma (HCCC) is a rare malignant tumor originating from salivary glands and described as a distinct entity from other clear cell salivary gland tumors by Milchgrub et al. in 1994. 1 Clinic behavior of HCCC is not well understood given the rarity of the tumor and the lack of analysis of reported series. It presents as a slow growing sub-mucosal mass without surface ulceration.

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Clear cell carcinoma of the mandibular gingiva ‘minor salivary gland’: a case report with immunohistochemical study

Cited by 21 publications

References 8 publications

Reappraising hyalinizing clear cell carcinoma: A population‐based study with molecular confirmation

Reappraising hyalinizing clear cell carcinoma: A population‐based study with molecular confirmation

Myoepithelial Cell and Its Prospective Role in Some Salivary Gland Tumors (An Immunohistochemical Study)

Hyalinizing Clear Cell Adenocarcinoma of the Hard Palate: Case Report

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