Clear Cell Carcinoma in a Background of Endometriosis

Rust, Megan M.; Susa, Joe; Naylor, Rebekah A.; Cavuoti, Dominick

doi:10.1159/000325557

Cited by 22 publications

(7 citation statements)

References 14 publications

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“…the presence of functional endometrial tissue in surgical incisions, is a complication that can develop after obstetrical or gynecological surgical procedures (50). A few cases of endometriosis-associated malignancies in abdominal surgical or episiotomy scars have been reported in the literature (51)(52)(53)(54).…”

Section: Malignant Extraovarian Endometriosismentioning

confidence: 99%

“…Endometriosis-associated malignancy in an abdominal surgical scar is a rare but aggressive phenomenon, with about 50 cases reported in the literature and with a median lag-time from surgery of approximately 19 years (51,52,54,(91)(92)(93)(94)(95)(96)(97)(98)(99)(100)(101)(102)(103)(104)(105)(106)(107)(108)(109)(110). These patients had previously undergone uterine surgery, mainly caesarean section and less frequently hysterectomy or myomectomy or surgery for uterine perforation.…”

Section: Endometriosis-associated Malignancies Of Surgical Scarsmentioning

confidence: 99%

See 1 more Smart Citation

Endometriosis-associated Extraovarian Malignancies: A Challenging Question for the Clinician and the Pathologist

Gadducci

Zannoni

2020

Anticancer Res

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Endometriosis is an estrogen-dependent disease, which affects 10% of women in the reproductive age. Malignant transformation is an uncommon event, which affects approximately 0.7-2.5% of women, and, when it occurs, it involves ovarian and extraovarian sites in 75% and 25% of the cases, respectively. Endometriosis correlates with presentation of clear cell and endometrioid carcinoma of the ovary. Activation of phosphatidylinositol 3-kinase (PIK3) -protein kinase B (AKT) -mammalian target of rapamycin (mTOR) pathway, aberrant chromatin remodeling due to AT-rich interactive domain-containing protein 1A (ARID1A) mutation and inactivation of estrogen receptor-α signaling seem to play a major role in the carcinogenesis.To date, little data are available regarding endometriosisassociated extraovarian malignancies. The aim of the present study was to review the clinical, pathological and prognostic features of endometriosis-related neoplasms arising from extraovarian sites, with particular focus on intestinal malignancies, urinary tract malignancies and tumors arising from surgical scars.

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Section: Malignant Extraovarian Endometriosismentioning

confidence: 99%

Section: Endometriosis-associated Malignancies Of Surgical Scarsmentioning

confidence: 99%

Endometriosis-associated Extraovarian Malignancies: A Challenging Question for the Clinician and the Pathologist

Gadducci

Zannoni

2020

Anticancer Res

View full text Add to dashboard Cite

show abstract

“…Papillae may show stromal hyalinization [ [20] , [21] , [22] ]. On immunohistochemical analysis, tumors cells show positivity for CK7, PAX8, Napsin A, hepatocyte nuclear factor (HNF1β) and exhibit negative staining for calretinin,WT-1, CK20,CD10, estrogen and progesterone receptors [ 7 , 22 , 23 ]. Wild-type p53 and focal p16 expression are also reported [ [20] , [21] , [22] ].…”

Section: Discussionmentioning

confidence: 99%

“…Wild-type p53 and focal p16 expression are also reported [ [20] , [21] , [22] ]. Differential diagnostics include metastasis of clear cell tumors of the female reproductive organs (ovarian, endometrial, cervical and vaginal) as well as metastasis of renal cell carcinoma, hepatocellular carcinoma and adrenal cortical tumors [ 23 ]. Other differential diagnostics include mesothelioma and urachal carcinoma [ 21 ].…”

Section: Discussionmentioning

confidence: 99%