Clear cell carcinoma arising from abdominal wall endometrioma after cesarean section

Lopes, André; Antón, Cristina; Slomovitz, Brian M.; Mattos, Leandro Accardo de; Carvalho, Filomena Marino

doi:10.1136/ijgc-2019-000808

Cited by 7 publications

(7 citation statements)

References 6 publications

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“…In terms of treatment, four patients received preoperative neoadjuvant chemotherapy (mainly platinum-based) [15][16][17][18], and one of them did not consider radical surgery because of the rapid progression of multiple metastases throughout the body [15]. Six patients were trying to treat vaginal estradiol medroxyprogesterone injection, leuprolide acetate, gestrinone, riptorelin, leiprim [10,[19][20][21][22], including our case, but the effect was not satisfactory. Surgery is the main treatment for the most of patients.…”

Section: Discussionmentioning

confidence: 84%

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Is clear cell carcinoma of abdominal wall surgery scar associated with endometriosis a poor prognosis? A case report and literature review

Liang

Zeng

Tang

et al. 2021

Preprint

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BackgroundClear cell carcinoma of abdominal wall surgery scar is a rare condition that can have many potential causes, and its early diagnosis is difficult after undergoing obstetrical and gynecological surgery unless performing tumor biopsy. So far, about 45 cases have been reported in the literature. This paper provides a case report and literature review of clear cell carcinoma on abdominal wall surgical scar.Case presentationWe described the case of a 47-year-old woman reporting two lumps in the scar of abdomen. Her medical history was marked by a previous Caesarean section and two excisions of benign endometriosis nodules at the scar. Physical examination found a mass of about 6×5×5 cm on the left side of the scar with mucoid on the surface and a fixed abdominal wall mass of about 10×10×8 cm in the 2 transverse fingers under the umbilicus. Histological examination proved a clear cell carcinoma result. The patient received tumor excision and first-line chemotherapy with complete remission. A review of the literature showed that 91.3% of the cases had had a Caesarean section. Besides, approximately 34.2% of women died 5–48 months after diagnosis. The average age of women was 46.5 years and the average tumor size was 10 cm.ConclusionThe abdominal wall mass of middle-aged women is closely related to the scar left by the previous Cesarean section and must be investigated in time and properly. Preoperative diagnosis is difficult and often incorrect, and there is no specific marker for malignant transformation. Treatment usually includes surgery, chemotherapy, and radiotherapy, but the prognosis is poor.

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Section: Discussionmentioning

confidence: 84%

“…As for tumor markers, CA 125 was detected in 24 cases before the operation. 14 cases were in the normal range (0-35U/mL), 10 cases were higher than the normal range, and the highest was 3157.9U/mL [10]. The preoperative detection of CEA,7 was in the normal range in 9 cases, above the normal range in 2 cases, up to 96.5 µg/L [11].…”

Section: Discussionmentioning

confidence: 86%

Is clear cell carcinoma of abdominal wall surgery scar associated with endometriosis a poor prognosis? A case report and literature review

Liang

Zeng

Tang

et al. 2021

Preprint

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“…Fifty‐seven full texts were assessed for eligibility; 20 of these were excluded for inclusion and exclusion criteria. Finally, 31 studies 28,31,33–60 were included in the review (Figure 1). Our review included 46 women of which characteristics are reported in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Clear cell degeneration associated with endometriosis of abdominal wall after cesarean section: A case report and systematic review of literature

Ferrari

Forte

Ardighieri

et al. 2021

J of Obstet and Gynaecol

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Aim The scar of cesarean section (CS) is the most common site of abdominal wall endometriosis (AWE), whose tumor degeneration has been reported in an increasing number of cases; the most frequent histological type is clear cell carcinoma (CCC). Methods We conducted a systematic research of the literature, collecting data regarding the evidence on tumor degeneration from AWE after CS. Moreover, we reported a case of clear cell borderline tumor (CCBT) originating from AWE. Results We included data of 37 patients with diagnosis of CCC. The average time between the last CS and the diagnosis of CCC was around 15 years. Overall, 26.0% and 73.9% patients received exclusive local abdominal resection of the lesion and additional surgery, respectively. Lymph nodes involvement was detected in 26.0 % patients and adjuvant chemotherapy was administered in 52.0 % cases. During follow‐up period, 15.2% patients died of disease, 32.6% had no evidence of disease, and 17.4% recurred. We diagnosed a CCBT arose in a patients with AWE and a personal history of several surgical procedures for endometriosis, a CS and a subsequent transverse laparotomy. We performed an open bilateral ovariectomy and a large excision of the endometriotic abdominal lesion. Conclusion Tumor degeneration from AWE seems to be a real occurrence with an increasing number of events. Considering the lack of risk factors and diagnostic instruments for tumor degeneration, the removal of AWE localization could be advisable, even though there was long average time between the trigger surgery and the tumor finding.

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“…The clear cells lining the papillae and cystic spaces often display hobnail configuration. Papillae may show stromal hyalinization [ [20] , [21] , [22] ]. On immunohistochemical analysis, tumors cells show positivity for CK7, PAX8, Napsin A, hepatocyte nuclear factor (HNF1β) and exhibit negative staining for calretinin,WT-1, CK20,CD10, estrogen and progesterone receptors [ 7 , 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Papillae may show stromal hyalinization [ [20] , [21] , [22] ]. On immunohistochemical analysis, tumors cells show positivity for CK7, PAX8, Napsin A, hepatocyte nuclear factor (HNF1β) and exhibit negative staining for calretinin,WT-1, CK20,CD10, estrogen and progesterone receptors [ 7 , 22 , 23 ]. Wild-type p53 and focal p16 expression are also reported [ [20] , [21] , [22] ].…”

Section: Discussionmentioning

confidence: 99%

Clear cell carcinoma of the abdominal wall: A case report with a review of the literature

Bellalah

Lahbecha

Zokar

et al. 2022

Annals of Medicine &Amp; Surgery

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Clear cell carcinoma arising from abdominal wall endometrioma after cesarean section

Cited by 7 publications

References 6 publications

Is clear cell carcinoma of abdominal wall surgery scar associated with endometriosis a poor prognosis? A case report and literature review

Is clear cell carcinoma of abdominal wall surgery scar associated with endometriosis a poor prognosis? A case report and literature review

Clear cell degeneration associated with endometriosis of abdominal wall after cesarean section: A case report and systematic review of literature

Clear cell carcinoma of the abdominal wall: A case report with a review of the literature

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