Clear Cell Borderline Ovarian Tumor: Clinical Characteristics, Prognosis, and Management

Clear Cell Borderline Tumor of the Ovary: A Case Report

“…CCBOT is a rare subtype of borderline ovarian tumors. CCBOT is pathologically defined as ‘‘an adenofibromatous clear cell tumor with glandular crowding and low-grade nuclear atypia without stromal invasion” in the 2020 World Health Organization classification ( 1 ).…”

“…In the literature, the mean age of patients was reported as 61 years (range, 30–86 years). Only four cases of CCBOT in premenopausal female have been reported so far ( 1 ). In our case, the patient was a premenopausal 22-year-old female, making her the youngest patient with CCBOT reported, to our knowledge.…”

“…Most clear cell ovarian tumors are malignant, while benign and borderline clear cell tumors are rare. Clear cell borderline ovarian tumors (CCBOTs) account for less than 1% of all borderline ovarian tumors ( 1 ). CCBOT is defined as “a tumor composed of glands or cysts lined by bland cuboidal to flattened cells with clear or eosinophilic cytoplasm and atypia, but without stromal invasion” ( 2 ).…”

“…CCBOT is defined as “a tumor composed of glands or cysts lined by bland cuboidal to flattened cells with clear or eosinophilic cytoplasm and atypia, but without stromal invasion” ( 2 ). Due to the rarity of CCBOTs, few cases have been reported in the literature ( 1 3 4 ). Herein, we present a case of surgically confirmed CCBOT, and discuss the MRI findings and clinicopathological features.…”

Rare Ovarian Tumors

“…They usually accompany clear cell adenocarcinoma and express similar genetic mutations in PIK3CA and ARID1A (106). A clinicopathologic study of 19 cases of CCBT demonstrated that all cases were FIGO stage I and that two instances of recurrence were associated with intraoperative tumor rupture (107). Histology is notable for cells with clear or eosinophilic cytoplasm embedded in fibromatous stroma (108).…”