Clear-Cell Adenocarcinoma of Vesical Origin: A Case Study of Metastatic Disease Treated with Chemotherapy

Alvarez, C.; Lorenzo, Isabel Lorenzo; Ferreiro, Silvia Varela; Gómez, Rosa Pardavila; Oh, Hae Jin; Rodríguez, Andrea Sáenz de Miera; Rúa, Marta Covela; Luyo, Wilver Federico Carbonell; Arroyo, Francisco Ramon Garcia; Clemente, Pedro López; Ozores, P. Palacios; Figueiras, Manuel Constenla

doi:10.1155/2010/426973

Cited by 3 publications

(4 citation statements)

References 8 publications

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“…Alvarez et al [ 29 ] concluded the following. The combination of clear cell and transitional adenocarcinoma in this case did not allow for the role of each histology in determining the outcome and the poor response to therapy.…”

Section: Discussion and Miscellaneous Narrations From Reported Casmentioning

confidence: 99%

“…Alvarez et al [ 29 ] reported a 49-year-old woman who underwent transurethral resection of bladder tumour on two occasions. The final histological diagnosis of the tumour was clear cell adenocarcinoma with infiltration into the muscle layer of the bladder (pT2).…”

Section: Discussion and Miscellaneous Narrations From Reported Casmentioning

confidence: 99%

“…Alvarez et al [ 29 ] stated the following. The clinical presentation of clear cell carcinoma of the urinary bladder is the same as that of urothelial tumours: voiding symptoms, acute urinary retention, and haematuria [ 23 ].…”

Section: Discussion and Miscellaneous Narrations From Reported Casmentioning

confidence: 99%

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Primary Clear Cell Carcinoma of the Urinary Bladder

Venyo

2014

International Scholarly Research Notices

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Primary clear cell carcinoma of the urinary bladder (PCCUB) is rare. Literature review has revealed 47 cases of PCCUB which commonly affects women. The histogenesis of PCCUB is not certain and Müllerian origin and urotheilal origin have been postulated. The microscopic characteristics of PCCUB include cells with abundant clear cytoplasm, arranged in a solid, glandular, tubulocystic, or papillary pattern. The cells may be flat or cuboidal with abundant clear eosinophilic cytoplasm. Hobnailing may be evident. PCCUB, on immunohistochemistry, stain positively with pan-cytokeratin, cytokeratin 7, and CA 125. PCCUB may manifest with visible haematuria, lower urinary tract symptoms, and discharge. There is no consensus opinion regarding the best treatment option for PCCUBs and patient outcomes are not very clear. Surgery has been the adopted treatment of choice. Differential diagnoses of PCCUB include nephrogenic metaplasia, urothelial carcinoma with clear cell cytoplasm, diffuse large B-cell lymphoma, and metastatic clear cell carcinoma with the primary originating elsewhere. Conclusions. A thorough radiological imaging assessment is required in cases of PCCUB to exclude a primary tumour elsewhere. Urologists and oncologists should report cases of PCCUB they encounter and should enter them into a multicentric trial to ascertain the best management option.

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Section: Discussion and Miscellaneous Narrations From Reported Casmentioning

confidence: 99%

Section: Discussion and Miscellaneous Narrations From Reported Casmentioning

confidence: 99%

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Primary Clear Cell Carcinoma of the Urinary Bladder

Venyo

2014

International Scholarly Research Notices

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“…There is evidence that chemotherapy for more advanced disease provides no survival benefit. Agents used in the past have included cisplatin, doxorubicin, cyclophosphamide, and 5-Fluoruracil [12,13]. These have only been used in sporadic cases and so it is uncertain whether there are any untried chemotherapy agents which may provide some benefit.…”

Section: Discussionmentioning

confidence: 99%