CLEAR CELL ADENOCARCINOMA OF THE FEMALE URETHRA A Case Report

Abstract

A case of urethral clear cell adenocarcinoma (mesonephric carcinoma) in a 62‐year‐old woman is reported. The patient consulted our hospital because of acute urinary retention. Fine needle aspiration cytology showed a few atypical cells; loose cluster cells with finely vacuolated cytoplasm, large nuclei and prominent nucleoli, and small cluster cells with finely vacuolated, delicate cytoplasm, small pale nuclei and small nucleoli. Cytologic diagnosis was adenocarcinoma and no diagnosis of clear cell adenocarcinoma was obtained. The neoplasia was localized at the posterior wall of the urethra and deep muscular layer of the vaginal wall. Histologically, the tumor revealed mainly small, elongated glands consisting of single‐layered cuboidal or columnar cells with scanty cytoplasm and a focally hobnail appearance. In addition, a small cystic lesion resembling nephrogenic adenoma was observed. This finding raises the possibitily that clear cell adenocarcinoma may be a malignant counterpart of nephrogenic adenoma. ACTA PATHOL JPN 38: 217–223, 1988.

Clear Cell Adenocarcinoma of the Male Urethra in Association with So-Called Nephrogenic Metaplasia

“…The morphologic similarities between 'nephrogenic adenoma' and well-differentiated clear cell adenocarcinomas and the difficulties in separating both lesions have been repeatedly stressed [10,11,19]. Association of urethral clear cell adenocarcinomas with so-called nephrogenic metaplasia -as observed in the present case -was also reported by others [7,14]; the report of Rivard and Waisman [5] showed a figure with a lesion that unequivocally represents a nephrogenic metaplasia of the papillary subtype in association with a 'mesonephric carcinoma'. In support of the hypothesis that clear cell adenocarcinomas may develop from preexisting nephrogenic metaplasia following malignant transformation are the cellular atypias identified within the nephrogenic lesion present in the current case.…”

Cytological diagnosis of nonulcerative penile neoplasms: Report of two cases

“…FNAC for urethral lesions have been reported. [12][13][14][15] We do not believe that FNAC would result in a fistula. In addition, as surgery is the treatment of choice for urethral carcinoma, the whole region would be included in the surgical excision.…”

Carcinoma de uretra feminina

“…Realizou-se, então, uretrocistoscopia estagiadora onde se identificou que a lesão vegetante comprometia somente a metade distai da uretra, sem evidência de lesão na uretra proximal e bexiga. A Comentários O câncer da uretra feminina atinge principalmente mulheres brancas na sexta e sétima décadas [2,3,4,6], Os tipos histológicos mais frequentes são o carcino ma epidermóide, carcinoma de células transicionais e 0 adenocarcinoma, com menor incidência de melanoma e carcinoma de células claras [5,6,8,9]. Não é infrequente encontrar neoplasia no interior de um divertículo, neste caso o tipo histológico predominante é 0 adenocarcinoma [10].…”