Clear cell adenocarcinoma arising in endometrial adenofibroma

Mikami, Shuji; Kikunaga, Hiroyuki; Kameyama, Kaori; Mukai, Makio

doi:10.1111/j.1440-1827.2010.02643.x

Cited by 3 publications

(3 citation statements)

References 8 publications

(15 reference statements)

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“…Searching the recent literature on CCC that arises in mixed epithelial and mesenchymal tumors of the female genital tract resulted in one single case describing CCC that arises in endometrial adenofibroma [ 8 ]. According to the classification of tumors in the female genital tract [ 9 ], adenofibroma was defined as a subtype of mixed epithelial and mesenchymal tumors composed of benign stromal and Mullerian epithelial components.…”

Section: Discussionmentioning

confidence: 99%

“…Basically, it is believed that most tumors diagnosed as adenofibromas, in fact, represent either low-grade AS or benign endometrial polyps. According to the original description of the mesenchymal component of the collisional tumor described by Mikami et al [ 8 ], it is more probable that the tumor described represented an endometrial polyp in which CCC arose.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clear Cell Carcinoma Arising in Low-Grade Mullerian Adenosarcoma: First Reported Case with Insight into Molecular Profile

Gašljević,

Vivod,

Škerl

et al. 2023

Case Rep Oncol

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Uterine adenosarcoma (AS) is a rare biphasic neoplasm composed of a malignant, usually low-grade stromal component and benign epithelial component, usually endometrioid. Pathogenesis is unknown; some cases are undoubtably associated with tamoxifen use. Endometrial clear cell carcinoma (CCC) is an aggressive subtype of endometrial cancer, accounting for less than 10% of all uterine carcinomas. The etiology is unknown but can rarely be associated with Lynch syndrome and tamoxifen administration. The development of a composite neoplasm consisting of adenocarcinoma in AS is extremely rare. Endometrioid carcinoma typically represents the epithelial component of the composite tumor. Here we present the very first case of composite tumor, namely, AS with CCC in which next-generation sequencing was performed. Patient was an 85-year-old woman treated with tamoxifen for 5 years. To better understand the pathobiology of two tumors, a targeted genomic analysis of both components was performed. We found seven identical somatic variants in the samples of both tumors, indicating that the tumors have a high probability of having the same origin. Dual amplification of CDK4 and MDM2 was the most likely primary cause of tumor formation, but also one driver variant in the DHX15 gene that was present in both tumor components, suggesting that DHX15 may play an important role in the initiation and development of sarcoma and carcinoma. The patient is followed by regular clinical controls and is alive without signs of disease recurrence 18 months after surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clear Cell Carcinoma Arising in Low-Grade Mullerian Adenosarcoma: First Reported Case with Insight into Molecular Profile

Gašljević,

Vivod,

Škerl

et al. 2023

Case Rep Oncol

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“…Uterine cervical adenofibroma was first reported by Abell in 1971 as a form of mixed mesodermal tumour which is composed of benign stromal and epithelial components [1]. Benign cervical adenofibroma is rare and has a strong proclivity for local recurrence and potential for developing to adenosarcoma, which is characterized by benign epithelial glands and malignant stromal elements [2,3]. Adenosarcoma is a low-grade malignancy which is often described as a midway point between benign adenofibroma and malignant carcinosarcoma [4].…”

Section: Introductionmentioning

confidence: 99%

Recurrent cervical adenofibroma progressing to adenosarcoma: a rare case report

2023

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Objectives: Cervical adenofibroma is a rare form of mixed mesodermal tumor that can present as cervical polyps with a tendency for local recurrence and progression. Few cases progressing to adenosarcoma have previously been reported. We report a case of cervical adenofibroma progressing to adenosarcoma, and we seek to remind clinicians of the method and importance of the differential diagnosis of this disease. Material and methods:A fertile woman was admitted in our department for the eighth recurrence of a cervical polypoidal mass which for the past 10 years. Recurrence of cervical adenofibroma was confirmed by ultrasound and MRI. A wide local excision under hysteroscopy was performed due to her strong desire to preserve the uterus.Results: Surgical pathology and immunohistochemical interpretation revealed cervical adenosarcoma. A hysterectomy with conservation of the ovaries was recommended, with regular follow-ups for evidence of disease recurrence.Conclusions: Differential diagnoses of cervical adenofibroma are hard to prove. Adenosarcoma should be ruled out, especially in women presenting with recurrent cervical polypoidal masses. A combined histological/immunohistochemical investigation is mandatory.

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Imaging Features of Carcinosarcoma Arising from Adenofibroma of the Uterus: A Case Report

Park

Han

et al. 2020

CMIR

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Adenofibroma is a benign tumor composed histologically of epithelial elements and mesenchymal stroma. Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma. Carcinosarcoma arising from adenofibroma of the uterus has never been reported in the English literature. We report a case of a 56-year-old woman who complained vaginal spotting persisting for several months. We describe here for the first time a case of malignant transformation of uterine endometrial adenofibroma into carcinosarcoma that was depicted as a multilocular cystic lesion with enhancing solid portions and stalk-like structure between the myometrium and endometrial mass.

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Clear cell adenocarcinoma arising in endometrial adenofibroma

Cited by 3 publications

References 8 publications

Clear Cell Carcinoma Arising in Low-Grade Mullerian Adenosarcoma: First Reported Case with Insight into Molecular Profile

Clear Cell Carcinoma Arising in Low-Grade Mullerian Adenosarcoma: First Reported Case with Insight into Molecular Profile

Recurrent cervical adenofibroma progressing to adenosarcoma: a rare case report

Imaging Features of Carcinosarcoma Arising from Adenofibroma of the Uterus: A Case Report

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