Clear castable polyurethane elastomer for fabrication of microfluidic devices

Domanský, Karel; Leslie, Daniel C.; McKinney, James; Fraser, Jacob P.; Sliz, Josiah; Hamkins-Indik, Tiama; Hamilton, Geraldine A.; Bahinski, Anthony; Ingber, Donald E.

doi:10.1039/c3lc50558h

Cited by 108 publications

(75 citation statements)

References 22 publications

(32 reference statements)

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“…In most cases, these plastics offer an adequate balance between fabrication procedures, cost, and analytical performance. Polymeric materials can be divided into two main groups: elastomers (including for example, PDMS [20] and polyurethane [21]) and thermoplastics (comprising polycarbonate and PMMA). Due to its high mechanic and chemical stability, optical transparency, and excellent dielectric properties [22], PMMA has become one of the most popular substrates for ME systems.…”

Section: Introductionmentioning

confidence: 99%

Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving

Gabriel,

Coltro,

Garcia

2014

Electrophoresis

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This paper describes the effects of different modes and engraving parameters on the dimensions of microfluidic structures produced in PMMA using laser engraving. The engraving modes included raster and vector while the explored engraving parameters included power, speed, frequency, resolution, line-width and number of passes. Under the optimum conditions, the technique was applied to produce channels suitable for CE separations. Taking advantage of the possibility to cut-through the substrates, the laser was also used to define solution reservoirs (buffer, sample, and waste) and a PDMS-based decoupler. The final device was used to perform the analysis of a model mixture of phenolic compounds within 200 s with baseline resolution.

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Section: Introductionmentioning

confidence: 99%

Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving

Gabriel,

Coltro,

Garcia

2014

Electrophoresis

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“…Another commonly recognized limitation is the high hydrophobicity of PDMS, which is linked to its ability to absorb small hydrophobic molecules motivating the development of novel materials, e.g. polyurethanes to replace PDMS (170). …”

Section: Applications Of Tissue Engineering In Modeling Of Cardiacmentioning

confidence: 99%

The Role of Tissue Engineering and Biomaterials in Cardiac Regenerative Medicine

Zhao

Feric

Thavandiran

et al. 2014

Canadian Journal of Cardiology

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In recent years, the development of three-dimensional engineered heart tissue (EHT) has made large strides forward due to advances in stem cell biology, materials science, pre-vascularization strategies and nanotechnology. As a result, the role of tissue engineering in cardiac regenerative medicine has become multi-faceted as new applications become feasible. Cardiac tissue engineering has long been established to have the potential to partially or fully restore cardiac function following cardiac injury. However, EHTs may also serve as surrogate human cardiac tissue for drug-related toxicity screening. Cardiotoxicity remains a major cause of drug withdrawal in the pharmaceutical industry. Unsafe drugs reach the market because pre-clinical evaluation is insufficient to weed out cardiotoxic drugs in all their forms. Bioengineering methods could provide functional and mature human myocardial tissues, i.e. physiologically relevant platforms, for screening the cardiotoxic effects of pharmaceutical agents and facilitate the discovery of new therapeutic agents. Finally, advances in induced pluripotent stem cells have made patient-specific EHTs possible, which opens up the possibility of personalized medicine. Herein, we give an overview of the present state of the art in cardiac tissue engineering, the challenges to the field and future perspectives.

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“…In addition, PDMS poses challenges for large-scale reproduction of microfluidic chambers. However, studies have been performed to identify suitable alternative materials or surface coating techniques to combat this issue [140][141][142].…”

Section: Bringing Cell Culture Techniques Closer To In Vivo: Future Dmentioning

confidence: 99%

Organoids, organs-on-chips and other systems, and microbiota

May

Evans

Parry

2017

Emerging Topics in Life Sciences

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The human gut microbiome is considered an organ in its entirety and has been the subject of extensive research due to its role in physiology, metabolism, digestion, and immune regulation. Disequilibria of the normal microbiome have been associated with the development of several gastrointestinal diseases, but the exact underlying interactions are not well understood. Conventional in vivo and in vitro modelling systems fail to faithfully recapitulate the complexity of the human host-gut microbiome, emphasising the requirement for novel systems that provide a platform to study human host-gut microbiome interactions with a more holistic representation of the human in vivo microenvironment. In this review, we outline the progression and applications of new and old modelling systems with particular focus on their ability to model and to study host-microbiome cross-talk.

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Clear castable polyurethane elastomer for fabrication of microfluidic devices

Cited by 108 publications

References 22 publications

Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving

Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving

The Role of Tissue Engineering and Biomaterials in Cardiac Regenerative Medicine

Organoids, organs-on-chips and other systems, and microbiota

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