Studies of populism have shifted from substantive to discursive/performative and institutional perspectives in recent decades. This shift resolved some long-standing problems but insulated the analysis of populism from theoretical and methodological debates in the social sciences. Theoretical restrictions have gone hand in hand with geographical neglect: The near-exclusive focus on the United States, Europe, and Latin America reinforces the blind spots of these existing approaches. An integration of overlooked regions holds the potential for theoretical reconstruction, even though such comparative broadening could as well simply reproduce the persistent impasses. Moreover, post-2016 developments have induced a return to substantive issues, throwing into sharp relief what populism studies have been missing during the past decades. The main challenge today is synthesizing socioeconomic analyses with institutionalist and discourse-theoretical advances without falling into eclecticism. Breaking away from the entrenched regional orientations to embrace a more global-historical methodology could help such an endeavor. Expected final online publication date for the Annual Review of Sociology, Volume 47 is July 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.