CLCA2 expression is associated with survival among African American women with triple negative breast cancer

Purrington, Kristen; Knight, Jimmie; Dyson, Gregory; Ali-Fehmi, Rouba; Schwartz, Ann G.; Boerner, Julie L.; Bandyopadhyay, Sudeshna

doi:10.1371/journal.pone.0231712

Cited by 15 publications

(16 citation statements)

References 41 publications

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“…Since the effect of ERK1/2 and ERK5 pathways on EMT is less well-understood in TNBCs, we first used publicly available datasets from Purrington, K. S. and colleagues [22] to correlate MAPK3 (ERK1), MAPK1(ERK2), or MAPK7 (ERK5) gene expression with EMT markers CDH1 (E-cadherin), ZEB1, or vimentin in primary, invasive tumors derived from African-American TNBC patients ( Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer

Bhatt

Wright

Barnes

et al. 2021

Translational Oncology

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Section: Resultsmentioning

confidence: 99%

Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer

Bhatt

Wright

Barnes

et al. 2021

Translational Oncology

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“…The survival analysis of TNBC has gotten enough attention from researchers around the world due to its severity and poor survival outcome. There are several studies focusing on the roles of clinical and treatment factors ( Xiao, 2016 ; Kim et al, 2019 ; Wen et al, 2020 ), radiomics features ( Kim S. et al, 2020 ; Koh et al, 2020 ), circulating tumor cells ( Karhade, 2012 ), and gene expressions ( Kim et al, 2016 ; Purrington et al, 2020 ; Wu et al, 2020 ) in the survival prognosis of TNBC. The research groups of these studies tried to find the significant risk factors for TNBC survival and further contributed to the treatment of TNBC.…”

Section: Discussionmentioning

confidence: 99%

The Functional Impact of Alternative Splicing on the Survival Prognosis of Triple-Negative Breast Cancer

Wang

Zhu

et al. 2021

Front. Genet.

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PurposeTriple-negative breast cancer (TNBC) is a type of breast cancer (BC) showing a high recurrence ratio and a low survival probability, which requires novel actionable molecular targets. The involvement of alternative splicing (AS) in TNBC promoted us to study the potential roles of AS events in the survival prognosis of TNBC patients.MethodsA total of 150 TNBC patients from The Cancer Genome Atlas (TCGA) were involved in this work. To study the effects of AS in the recurrence-free survival (RFS) prognosis of TNBC, we performed the analyses as follows. First, univariate Cox regression model was applied to identify RFS-related AS events. Their host genes were analyzed by Metascape to discover the potential functions and involved pathways. Next, least absolute shrinkage and selection operator (LASSO) method was used to select the most informative RFS-related AS events to constitute an AS risk factor for RFS prognosis, which was evaluated by Kaplan–Meier (KM) and receiver operating characteristic (ROC) curves in all the data and also in different clinical subgroups. Furthermore, we analyzed the relationships between splicing factors (SFs) and these RFS-related AS events to seek the possibility that SFs regulated AS events to influence RFS. Then, we evaluated the potential of these RFS-related AS events in the overall survival (OS) prognosis from all the above aspects.ResultsWe identified a total of 546 RFS-related AS events, which were enriched in some splicing and TNBC-associated pathways. Among them, seven RFS-related events were integrated into a risk factor, exhibiting satisfactory RFS prognosis alone and even better performance when combined with clinical tumor–node–metastasis stages. Furthermore, the correlation analysis between SFs and the seven AS events revealed the hypotheses that SRPK3 might upregulate PCYT2_44231_AA to have an effect on RFS prognosis and that three other SFs may work together to downregulate FLAD1_7874_RI to influence RFS prognosis. In addition, the seven RFS-related AS events were validated to be promising in the OS prognosis of TNBC as well.ConclusionThe abnormal AS events regulated by SFs may act as a kind of biomarker for the survival prognosis of TNBC.

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“…Beyond surgical resection and chemoradiotherapy, a variety of new treatment methods have helped improve BC patient prognosis and the cure rate of advanced patients [16]. Endocrine and targeted therapies for BC have made progress, and traditional Chinese medicine also has unique advantages in the fight against advanced BC [17]. A variety of traditional Chinese medicine extracts, such as the active triterpenoid monomer compound KHF16, have significant anti-tumor effects and inhibit BC cell proliferation [18,19].…”

Section: Discussionmentioning

confidence: 99%

Zerumbone decreases BACH1 levels by upregulating miR- 708 to inhibit breast cancer cell proliferation and invasion

Zhao¹,

Ma²,

Lv³

et al. 2020

Trop. J. Pharm Res

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Purpose: To investigate the potential mechanism by which zerumbone suppresses breast cancer (BC) cells.Methods: Cell viability and Transwell assays were performed to assess the effect of zerumbone on BC cell growth. The downstream target of zerumbone was determined using quantitative polymerase chain reaction assays and immunoblotting. Cell viability assays and immunoblotting were conducted to detect if zerumbone had any effect on BACH1 (BTB domain and CNC homolog 1) expression.Results: Zerumbone suppressed the proliferation, migration, and invasion of BC cells. It also upregulated the expression of microRNA (miR)-708 and, hence, suppressed BACH1 expression. Furthermore, zerumbone suppressed the proliferation and invasion of BC cells by promoting miR-708expression and suppressing BACH1.Conclusion: The findings help clarify the anti-tumor mechanism of zerumbone and provide theoretical and therapeutic bases for the anti-tumor effects of Chinese herbal medicine. Keywords: Breast cancer, Zerumbone, Cell invasion, MiR-708, BACH1

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CLCA2 expression is associated with survival among African American women with triple negative breast cancer

Cited by 15 publications

References 41 publications

Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer

Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer

The Functional Impact of Alternative Splicing on the Survival Prognosis of Triple-Negative Breast Cancer

Zerumbone decreases BACH1 levels by upregulating miR- 708 to inhibit breast cancer cell proliferation and invasion

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