Clavicle Fractures: To Operate or Not?

Moreno-García, Alonso; Rodríguez-Merchán, E. Carlos

doi:10.1007/978-3-031-04907-1_6

Cited by 2 publications

(2 citation statements)

References 48 publications

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“…The emergence of novel treatments employing the use of orthobiologics has provided physicians with feasible alternatives for the management of numerous orthopedic conditions, especially PC [1]. By definition, orthobiologics are organic or synthetic materials that promote enhanced healing of musculoskeletal disorders [9]. Many orthobiologic products have been discussed in the literature, including acellular solutions like hyaluronic acid (HA) and cellular alternatives such as platelet-rich plasma (PRP), injectable platelet-rich fibrin (i-PRF), bone marrow aspirate/bone marrow aspirate concentrate (BMA/BMAC) and adipose tissue derivatives [10][11][12][13][14].…”

Section: Gradementioning

confidence: 99%

The Synergistic Effects of Hyaluronic Acid and Platelet-Rich Plasma for Patellar Chondropathy

Costa,

Santos,

Martins

et al. 2023

Biomedicines

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Musculoskeletal disorders are increasingly prevalent worldwide, causing significant socioeconomic burdens and diminished quality of life. Notably, patellar chondropathy (PC) is among the most widespread conditions affecting joint structures, resulting in profound pain and disability. Hyaluronic acid (HA) and platelet-rich plasma (PRP) have emerged as reliable, effective, and minimally invasive alternatives. Continuous research spanning from laboratory settings to clinical applications demonstrates the numerous advantages of both products. These encompass lubrication, anti-inflammation, and stimulation of cellular behaviors linked to proliferation, differentiation, migration, and the release of essential growth factors. Cumulatively, these benefits support the rejuvenation of bone and cartilaginous tissues, which are otherwise compromised due to the prevailing degenerative and inflammatory responses characteristic of tissue damage. While existing literature delves into the physical, mechanical, and biological facets of these products, as well as their commercial variants and distinct clinical uses, there is limited discussion on their interconnected roles. We explore basic science concepts, product variations, and clinical strategies. This comprehensive examination provides physicians with an alternative insight into the pathophysiology of PC as well as biological mechanisms stimulated by both HA and PRP that contribute to tissue restoration.

show abstract

Section: Gradementioning

confidence: 99%

The Synergistic Effects of Hyaluronic Acid and Platelet-Rich Plasma for Patellar Chondropathy

Costa,

Santos,

Martins

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

“…The emergence of novel treatments employing the use of orthobiologics have provided physicians feasible alternatives for the management of numerous orthopedic conditions, especially PC [1]. By definition, orthobiologics are organic or synthetic materials that promote enhanced healing of musculoskeletal disorders [7]. Many orthobiologic products have been discussed in the literature, including acellular solutions like hyaluronic acid (HA); and cellular alternatives such as platelet-rich plasma (PRP), injectable platelet-rich fibrin (i-PRF), bone marrow aspirate/bone marrow aspirate concentrate (BMA/BMAC) and adipose tissue derivatives [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

The Synergistic Effects of Hyaluronic Acid and Platelet-Rich Plasma for Patellar Chondropathy

Costa,

Santos,

Martins

et al. 2023

Preprint

View full text Add to dashboard Cite

Musculoskeletal disorders are increasingly prevalent worldwide, causing significant socioeconomic burdens and diminished quality of life. Notably, patellar chondropathy (PC) is among the most widespread conditions affecting the joint structures, resulting in profound pain and disability. Hyaluronic acid (HA) and platelet-rich plasma (PRP) have emerged as reliable, effective, and minimally invasive alternatives. Continuous research spanning from laboratory settings to clinical applications demonstrate the numerous advantages of both products. These encompass lubrication, anti-inflammation, and stimulation of cellular behaviors linked to proliferation, differentiation, migration, and the release of essential growth factors. Cumulatively, these benefits support the rejuvenation of bone and cartilaginous tissues, which are otherwise compromised due to the prevailing degenerative and inflammatory responses characteristic of tissue damage. While existing literature delves into the physical, mechanical, and biological facets of these products, as well as their commercial variants and distinct clinical uses, there is limited discussion on their interconnected roles. We explore basic science concepts, product variations, and clinical strategies. This comprehensive examination provides physicians with an alternative insight into the pathophysiology of PC as well as biological mechanisms stimulated by both HA and PRP that contribute to tissue restoration.

show abstract

Clavicle Fractures: To Operate or Not?

Cited by 2 publications

References 48 publications

The Synergistic Effects of Hyaluronic Acid and Platelet-Rich Plasma for Patellar Chondropathy

The Synergistic Effects of Hyaluronic Acid and Platelet-Rich Plasma for Patellar Chondropathy

The Synergistic Effects of Hyaluronic Acid and Platelet-Rich Plasma for Patellar Chondropathy

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