Clausenol and clausenine—two carbazole alkaloids from Clausena anisata

Phytochemical Investigation and Anti-Microbial Activity of <i>Clausena Anisata</i> (Willd), Hook.

“…Compounds such as coumarins including furanocoumarins, imperatorin, oxypeucedanine and chalepin have been isolated from the root and stem bark (Chakraborty et al, 1995;Mester et al, 1997). A carbazole alkaloid, clausenol has been isolated from the ethanol extract of the stem bark and coumarins, limonoids, reducing sugars and alkaloids have been found in the stem bark (Chakraborty et al, 1995), and essential oils including β-pinene and sabinene chemotypes (Senthikumar and Venkatesalu, 2009), have been found in the leaves.…”

“…A carbazole alkaloid, clausenol has been isolated from the ethanol extract of the stem bark and coumarins, limonoids, reducing sugars and alkaloids have been found in the stem bark (Chakraborty et al, 1995), and essential oils including β-pinene and sabinene chemotypes (Senthikumar and Venkatesalu, 2009), have been found in the leaves. The stem bark of C. anisata has been found to possess antimicrobial property (Chakraborty et al, 1995), anti-parasitic and central nervous depressant activity (Makanju, 1983), and root and stem bark exhibiting hypoglycaemic property (Ojewole, 2002). The aims of the study was to evaluate the antimicrobial activity of ethanol leaf extract of C. anisata and its methanol, chloroform and petroleum ether fractions against some microorganisms and also perform preliminary phytochemical screening on the ethanol extract and its fractions of C. anisata.…”

Epidihydropinidine, the main piperidine alkaloid compound of Norway spruce (Picea abies) shows promising antibacterial and anti-Candida activity

“…An important driving force to explore new plants and other organisms for biologically active compounds is also the accelerating pace of habitat destruction and therefore loss of valuable species [46]. Generally higher plants are regarded as a rich source of antimicrobial compounds, among which alkaloids represent a promising class of bioactive compounds [47,48,49,50,51,52]. Antimicrobial activity of alkaloids is dependent on the structural class, so that piperidine, pyrrolidine and pumiliotoxine alkaloids have been found to be the most inhibitory [47,53,54].…”

Comparative Study of Chemical Profiles of Leaf, Root and Seed Essential Oils of Clausena anisata (Willd.) Hook

“…and diseases such as parasitic infections, especially flatworm infections, such as schistosomiasis, as well as in influenza, eye complaints and other respiratory ailments, heart disorder and hypertension; abdominal cramps; gastroenteritis and constipation, malaria, diabetics, pyrexia and fever, hepatic disease causing bad breath, rheumatism, boils, arthritis and other inflammatory conditions, headaches, toothaches, body pains, swollen gums, convulsion, mental disorders, impotencies [3][4][5][6][7][8][9][10][11].…”