Claudin 7 as a possible novel molecular target for the treatment of pancreatic cancer

Okui, Norimitsu; Kamata, Yuko; Sagawa, Yukiko; Kuhara, Akiko; Hayashi, Kazumi; Uwagawa, Tadashi; Homma, Sadamu; Yanaga, Katsuhiko

doi:10.1016/j.pan.2018.10.009

Cited by 9 publications

(4 citation statements)

References 44 publications

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“…CLDN7 (Claudin 7), a member of the claudin family, played an important role in the tight junction formation and function of the intercellular space [39]. Claudin family proteins have been declared to be expressed differently in diverse tumor tissues and CLDN7 was particularly relevant to gastric cancer [40], colon cancer [41], and pancreatic cancer [42]. In our study, the expression of CLDN7 in ChRCC was three times higher than the expression in RO, indicating that CLDN7 had the potential to differentiate ChRCC from RO.…”

Section: Biomed Research Internationalmentioning

confidence: 99%

Identification of Key Genes and Prognostic Analysis between Chromophobe Renal Cell Carcinoma and Renal Oncocytoma by Bioinformatic Analysis

Fan

et al. 2020

BioMed Research International

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The present techniques of clinical and histopathological diagnosis hardly distinguish chromophobe renal cell carcinoma (ChRCC) from renal oncocytoma (RO). To identify differentially expressed genes (DEGs) as effective biomarkers for diagnosis and prognosis of ChRCC and RO, three mRNA microarray datasets (GSE12090, GSE19982, and GSE8271) were downloaded from the GEO database. Functional enrichment analysis of DEGs was performed by DAVID. STRING and Cytoscape were applied to construct the protein-protein interaction (PPI) network and key modules of DEGs. Visualized plots were conducted by the R language. We downloaded clinical data from the TCGA database and the influence of key genes on the overall survival of ChRCC was performed by Kaplan–Meier and Cox analyses. Gene set enrichment analysis (GSEA) was utilized in exploring the function of key genes. A total of 79 DEGs were identified. Enrichment analyses revealed that the DEGs are closely related to tissue invasion and metastasis of cancer. Subsequently, 14 hub genes including ESRP1, AP1M2, CLDN4, and CLDN7 were detected. Kaplan–Meier analysis indicated that the low expression of CLDN7 and GNAS was related to the worse overall survival in patients with ChRCC. Univariate Cox analysis showed that CLDN7 might be a helpful biomarker for ChRCC prognosis. Subgroup analysis revealed that the expression of CLDN7 showed a downtrend with the development of the clinical stage, topography, and distant metastasis of ChRCC. GSEA analysis identified that cell adhesion molecules cams, B cell receptor signaling pathway, T cell receptor signaling pathway, RIG-I like receptor signaling pathway, Toll-like receptor signaling pathway, and apoptosis pathway were associated with the expression of CLDN7. In conclusion, ESRP1, AP1M2, CLDN4, PRSS8, and CLDN7 were found to distinguish ChRCC from RO. Besides, the low expression of CLDN7 was closely related to ChRCC progression and could serve as an independent risk factor for the overall survival in patients with ChRCC.

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Section: Biomed Research Internationalmentioning

confidence: 99%

Identification of Key Genes and Prognostic Analysis between Chromophobe Renal Cell Carcinoma and Renal Oncocytoma by Bioinformatic Analysis

Fan

et al. 2020

BioMed Research International

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“…DNA microarray analysis showed that claudin-7 was highly expressed in MIA PaCa-2-A cells, and claudin-7 knockdown in MIA-PaCa-2-A cells significantly inhibited pancreatic tumor proliferation, reduced expression of p-Erk1/2, and inhibited G1 cell cycle arrest. Thus, CLDN7 may be expressed in rapidly proliferating and dominant cell populations in human PCa tissues and could be a novel molecular target for PCa treatment ( 49 ).…”

Section: Expression Of Cldns In Pcamentioning

confidence: 99%

Claudin and pancreatic cancer

Wang

Wu²,

Pei³

et al. 2023

Front. Oncol.

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Due to the lack of timely and accurate screening modalities and treatments, most pancreatic cancer (PCa) patients undergo fatal PCa progression within a short period since diagnosis. The claudin(CLDN) family is expressed specifically as tight junction structure in a variety of tumors, including PCa, and affects tumor progression by changing the cell junctions. Thus far, many of the 27 members of the claudin family, including claudin-18.2 and claudin-4, have significantly aberrantly expression in pancreatic tumors. In addition, some studies have confirmed the role of some claudin proteins in the diagnosis and treatment of pancreatic tumors. By targeting different targets of claudin protein and combining chemotherapy, further enhance tumor cell necrosis and inhibit tumor invasion and metastasis. Claudins can either promote or inhibit the development of pancreatic cancer, which indicates that the diagnosis and treatment of different kinds of claudins require to consider different biological characteristics. This literature summarizes the functional characteristics and clinical applications of various claudin proteins in Pca cells, with a focus on claudin-18.2 and claudin-4.

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“…This protein regulates cell proliferation via integrins and maintains epithelial cell attachment, controlling the growth and cycle progression of cells and regulating tumour cell proliferation [ 89 ]. It has also been demonstrated that CLDN7 may be overexpressed in rapidly proliferating cell populations in PC tissues and could be used as a novel molecular target for PC treatment, similarly to CLDN12 and CLDN23 [ 61 ]. Some clinical investigations have proven that CLDN12 plays an oncogenic role in PC cells, promoting its malignant phenotype, and it might be a therapeutic target for inhibiting PC cell progression [ 90 , 91 ].…”

Section: Gastrointestinal Cancers (Gi)—general Characteristicsmentioning

confidence: 99%

Claudins—Promising Biomarkers for Selected Gastrointestinal (GI) Malignancies?

Łukaszewicz-Zając,

Mroczko

2023

Cancers

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Despite recent(最近) improvements in diagnostic ability(能力) and treatment(治疗) strategies for patients(病人) with neoplastic disease(疾病), gastrointestinal (GI) cancers(癌症), such(这样) as colorectal, gastric, pancreatic, and oesophageal cancers(癌症), are still common(常见) malignancies and the leading(领先) cause(原因) of cancer(癌症) deaths worldwide(全世界), with a high frequency of recurrence and metastasis as well as poor patient(病人) prognosis. There is a link(链接) between the secretion of proteolytic enzymes that degrade the extracellular matrix and the pathogenesis of GI tumours. Recent(最近) findings have focused(焦点) on the potential(潜在) significance(意义) of selected claudins (CLDNs) in the pathogenesis and prognosis of GI cancers(癌症). Tight junctions (TJs) have been proven to play an important role(作用) in maintaining cell(细胞) polarity and permeability. A number of authors have recently(最近) revealed that TJ proteins, particularly(特别是) selected CLDNs, are related(相关) to inflammation and the development(发展) of various tumours, including GI malignancies. This review(检讨) presents general(一般) characteristics and the involvement(参与) of selected CLDNs in the progression(进展) of GI malignancies, with a focus(焦点) on the potential(潜在) application(应用) of these proteins in the diagnosis(诊断) and prognosis of colorectal cancer(癌症) (CRC), gastric cancer(癌症) (GC), pancreatic cancer(癌症) (PC), and oesophageal cancer(癌症) (EC). Our review(检讨) indicates that selected CLDNs, particularly(特别是) CLDN1, 2, 4, 7, and 18, play a significant(显著) role(作用) in the development(发展) of GI tumours and in patient(病人) prognosis. Furthermore, selected CLDNs may be of value(价值) in the design(设计) of therapeutic(治疗) strategies for the treatment(治疗) of recurrent tumours.

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Claudin 7 as a possible novel molecular target for the treatment of pancreatic cancer

Cited by 9 publications

References 44 publications

Identification of Key Genes and Prognostic Analysis between Chromophobe Renal Cell Carcinoma and Renal Oncocytoma by Bioinformatic Analysis

Identification of Key Genes and Prognostic Analysis between Chromophobe Renal Cell Carcinoma and Renal Oncocytoma by Bioinformatic Analysis

Claudin and pancreatic cancer

Claudins—Promising Biomarkers for Selected Gastrointestinal (GI) Malignancies?

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