Claudin-15 and -25b expression in the intestinal tract of Atlantic salmon in response to seawater acclimation, smoltification and hormone treatment

Tipsmark, Christian K.; Sørensen, Kenneth; Hulgard, Katrine; Madsen, Steffen S.

doi:10.1016/j.cbpa.2009.11.025

Cited by 61 publications

(50 citation statements)

References 48 publications

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“…While keeping in mind that branchial expression of a-1b in SW is more than tenfold higher than that in FW, this still contrasts somewhat with findings in salmonids. In rainbow trout and Atlantic salmon, the a-1b isoform is not expressed Prolactin dependence of FW-type Na C , K substantially in the intestine (Richards et al 2003, Tipsmark et al 2010a. The distribution of Fxyd proteins is in accordance with previous studies.…”

Section: Discussionsupporting

confidence: 90%

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Switching of Na+, K+-ATPase isoforms by salinity and prolactin in the gill of a cichlid fish

Tipsmark

Breves²,

Seale³

et al. 2011

Journal of Endocrinology

105

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We identified and investigated the changes in expression of two gill Na C , K C -ATPase a-subunit isoforms (a-1a and a-1b) in relationship with salinity acclimation in a cichlid fish, Mozambique tilapia. Transfer of freshwater (FW)-acclimated fish to seawater (SW) resulted in a marked reduction in a-1a expression within 24 h and a significant increase in a-1b expression with maximum levels attained 7 days after the transfer. In contrast, transfer of SWacclimated fish to FW induced a marked increase in a-1a expression within 2 days, while a-1b expression decreased significantly after 14 days. Hypophysectomy resulted in a virtual shutdown of a-1a mRNA expression in both FW-and SW-acclimated fish, whereas no significant effect was observed in a-1b expression. Replacement therapy by ovine prolactin (oPrl) fully restored a-1a expression in FW-acclimated fish, while cortisol had a modest, but significant, stimulatory effect on a-1a expression. In hypophysectomized fish in SW, replacement therapy with oPrl alone or in combination with cortisol resulted in a marked increase in a-1a mRNA to levels far exceeding those observed in sham-operated fish. Expression of a-1b mRNA was unaffected by hormone treatment either in FW-acclimated fish or in SW-acclimated fish. The mRNA expression of fxyd-11, a regulatory Na C , K C -ATPase subunit, was transiently enhanced during both FW and SW acclimation. In hypophysectomized fish in FW, oPrl and cortisol stimulated fxyd-11 expression in a synergistic manner. The clear Prl dependence of gill a-1a expression may partially explain the importance of this hormone to hyperosmoregulation in this species.

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Section: Discussionsupporting

confidence: 90%

“…In tilapia, the a-1a isoform appears to be gill specific, as in rainbow trout (Richards et al 2003) and Atlantic salmon (Tipsmark et al 2010a). The tilapia a-1b isoform was highly expressed in the intestinal sections of FW specimens, with comparatively lower expression in the gill.…”

Section: Discussionmentioning

confidence: 99%

Switching of Na+, K+-ATPase isoforms by salinity and prolactin in the gill of a cichlid fish

Tipsmark

Breves²,

Seale³

et al. 2011

Journal of Endocrinology

105

View full text Add to dashboard Cite

show abstract

“…A previous study from our laboratory in riboflavin also shows the similar result [47]. The cause is still unknown, but the explanation may be that: (1) Claudin-15 was least expression abundant in the gill of Atlantic salmon [67], and thus nutrients (such as valine) had not significantly effect on low-abundant of TJ proteins [68]. (2) Claudin-15 play crucial roles in the transepithelial paracellular channel-like permselectivity for extracellular monovalent cations [69], which was involved in the osmoregulation of gill and important for the survival of fish [70].…”

Section: Choline Regulated Tj Proteins and Mlck Mrna Levels In The Gisupporting

confidence: 65%

Dietary choline regulates antibacterial activity, inflammatory response and barrier function in the gills of grass carp (Ctenopharyngodon idella)

Zhao

Jiang

Liu

et al. 2016

Fish & Shellfish Immunology

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“…The beneficial effects of dietary proteins on claudin 15a (rather than claudin 15b) gene expression may be partly associated with the Na þ transport capacity in the intestines of fish. Tipsmark et al [81] indicated that claudin 15 could regulate paracellular Na þ movement in the intestines of Atlantic salmon (Salmo salar). In Japanese medaka (Oryzias latipes) intestine, the mRNA levels of claudin 15a were significantly higher than the claudin 15b mRNA level in response to a salinity change, leading to a claudin 15b net transport of sodium that was negligible [82].…”

Section: General Summary: Optimal Dietary Protein Level Improve the Imentioning

confidence: 99%

Optimal dietary protein level improved growth, disease resistance, intestinal immune and physical barrier function of young grass carp (Ctenopharyngodon idella)

Jiang

et al. 2016

Fish & Shellfish Immunology

118

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Claudin-15 and -25b expression in the intestinal tract of Atlantic salmon in response to seawater acclimation, smoltification and hormone treatment

Cited by 61 publications

References 48 publications

Switching of Na+, K+-ATPase isoforms by salinity and prolactin in the gill of a cichlid fish

Switching of Na+, K+-ATPase isoforms by salinity and prolactin in the gill of a cichlid fish

Dietary choline regulates antibacterial activity, inflammatory response and barrier function in the gills of grass carp (Ctenopharyngodon idella)

Optimal dietary protein level improved growth, disease resistance, intestinal immune and physical barrier function of young grass carp (Ctenopharyngodon idella)

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