Claudin-1 expression in cervical cancer

Hoellen, Friederike; Waldmann, Annika; Banz‐Jansen, Constanze; Holtrich, Uwe; Karn, Thomas; Oberländer, Martina; Habermann, Jens K.; Hörmann, Mareike; Köster, Frank; Ribbat‐Idel, Julika; Thill, Marc; Rody, Achim; El‐Balat, Ahmed; Hanker, Lars

doi:10.3892/mco.2017.1391

Cited by 14 publications

(10 citation statements)

References 9 publications

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“…Increased expression of claudin-1 in cervical cancer was noticed by Zhang et al [60] and Hoellen et al [61]. Significant overexpression of claudin-1 was observed in tumor cells; although no correlation was found with Federation of Gynecology and Obstetrics (FIGO) stage, claudin-1-postive patients exhibited more lymph node metastasis as compared to claudin-1 negative patients [61]. A lot of studies have reported that the expression of claudin-1 correlates with tumor invasion: it is said that claudin-1 may improve anti-apoptosis ability and stimulate metastasis [60].…”

Section: Claudins In Cervical Cancermentioning

confidence: 79%

“…Claudin-1 has been proposed as a biomarker of cervical histology and cytology. Increased expression of claudin-1 in cervical cancer was noticed by Zhang et al [60] and Hoellen et al [61]. Significant overexpression of claudin-1 was observed in tumor cells; although no correlation was found with Federation of Gynecology and Obstetrics (FIGO) stage, claudin-1-postive patients exhibited more lymph node metastasis as compared to claudin-1 negative patients [61].…”

Section: Claudins In Cervical Cancermentioning

confidence: 95%

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Claudins: New Players in Human Fertility and Reproductive System Cancers

Kozieł

Kowalska

Piastowska-Ciesielska

2020

Cancers

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Claudins are major integral proteins of tight junctions (TJs), the apical cell-cell adhesions that enable maintaining polarity of epithelial cells, their differentiation, and cell signaling. A number of studies have indicated that claudins might play a crucial role in both physiology and pathogenesis. Their tissue-specific expression was originally linked to the development of different types of cancer and triggered a hope to use them as diagnostic or prognostic markers. However, it seems that their expression is more complex than that, and undoubtedly, claudins participate in one of the most important molecular events in cells. This review summarizes the recent research evaluating the role of claudins in fertility and the most common endocrine-dependent cancers in the reproductive system and highlights the crucial role of claudins both in human fertility and the most common cancers.

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Section: Claudins In Cervical Cancermentioning

confidence: 79%

Section: Claudins In Cervical Cancermentioning

confidence: 95%

Claudins: New Players in Human Fertility and Reproductive System Cancers

Kozieł

Kowalska

Piastowska-Ciesielska

2020

Cancers

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“…Nevertheless, claudin-1 has also been reported to be overexpressed in several cancerous tissues, including high-grade cervical intraepithelial neoplasias ( 78 ) and invasive cervical cancer ( 79 ), where it has been considered as a biomarker of the disease ( 80 ), with a prognosis potential ( 81 ). Claudin-1 was also found to be overexpressed in colorectal tumors ( 82 - 84 ), mucoepidermoid carcinomas of the salivary gland ( 85 ), thyroid papillary carcinomas, papillary microcarcinomas primary tumors and lymph node metastases ( 86 ), and esophageal ( 87 , 88 ), hypopharyngeal ( 89 , 90 ), tongue ( 91 ) and oral ( 92 ) squamous cell carcinomas, where claudin-1 was found to be associated with cell invasion and disease recurrence ( 93 ).…”

Section: Discussionmentioning

confidence: 99%

E7 oncoprotein from human papillomavirus 16 alters claudins expression and the sealing of epithelial tight junctions

Uc¹,

Miranda²,

Raya‐Sandino³

et al. 2020

Int J Oncol

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Tight junctions (TJs) are cell-cell adhesion structures frequently altered by oncogenic transformation. In the present study the role of human papillomavirus (HPV) 16 E7 oncoprotein on the sealing of TJs was investigated and also the expression level of claudins in mouse cervix and in epithelial Madin-Darby Canine Kidney (MDCK) cells. It was found that there was reduced expression of claudins-1 and-10 in the cervix of 7-month-old transgenic K14E7 mice treated with 17β-estradiol (E 2), with invasive cancer. In addition, there was also a transient increase in claudin-1 expression in the cervix of 2-month-old K14E7 mice, and claudin-10 accumulated at the border of cells in the upper layer of the cervix in FvB mice treated with E 2 , and in K14E7 mice treated with or without E 2. These changes were accompanied by an augmented paracellular permeability of the cervix in 2-and 7-month-old FvB mice treated with E 2 , which became more pronounced in K14E7 mice treated with or without E 2. In MDCK cells the stable expression of E7 increased the space between adjacent cells and altered the architecture of the monolayers, induced the development of an acute peak of transepithelial electrical resistance accompanied by a reduced expression of claudins-1,-2 and-10, and an increase in claudin-4. Moreover, E7 enhances the ability of MDCK cells to migrate through a 3D matrix and induces cell stiffening and stress fiber formation. These observations revealed that cell transformation induced by HPV16 E7 oncoprotein was accompanied by changes in the pattern of expression of claudins and the degree of sealing of epithelial TJs.

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“…Claudin, a representative epithelial marker, was shown to be significantly increased not only with miR-944 and ΔNp63 inhibition alone but also with the combination of miR-944 and ΔNp63 inhibition, as compared to with scramble ( Figure 5 ). Claudins, which are epithelial markers, are transmembrane proteins and important components of tight junctions (TJs), which are central to the regulation of paracellular permeability and for the maintenance of epithelial cell polarity [ 33 ]. The results reported by Kaneko et al, are consistent with our findings in that the knock-down of ΔNp63 in human nasal epithelial cells enhances barrier and fence functions, inducing claudin-1 and -4 and inhibiting p38 MAPK [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Synergetic Effects of Intronic Mature miR-944 and ΔNp63 Isoforms on Tumorigenesis in a Cervical Cancer Cell Line

Kim

Park

Chang

et al. 2020

IJMS

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miR-944 is located in an intron of the tumor protein p63 gene (TP63). miR-944 expression levels in cervical cancer tissues are significantly higher than in normal tissues and are associated with tumor size, International Federation of Gynecology and Obstetrics (FIGO) stage, lymph node metastasis, and survival. However, associations of miR-944 with its host gene, TP63, which encodes TAp63 and ΔNp63, in cervical cancer have not been fully investigated. A positive correlation between miR-944 and ΔNp63 mRNA expression was identified in cervical cancer tissues. Furthermore, when the expression of miR-944 and ΔNp63 was simultaneously inhibited, cell proliferation-, differentiation- epithelial–mesenchymal transition (EMT)-, transcription-, and virus-associated gene clusters were shown to be significantly more active according to functional annotation analysis. Cell viability and migration were more reduced upon simultaneous inhibition with anti-miR-944 or ΔNp63 siRNA than with inhibition with anti-miR-944 or ΔNp63 siRNA alone, or scramble. In addition, Western blot analysis showed that the simultaneous inhibition of miR-944 and ΔNp63 reduced EMT by increasing the expression of epithelial markers such as claudin and by decreasing mesenchymal markers such as N-cadherin and vimentin. Slug, an EMT transcription factor, was also decreased by the simultaneous inhibition of miR-944 and ΔNp63. Thus, associations between miR-944 and ΔNp63 in cervical cancer could help to elucidate the function of this intronic microRNA and its role in carcinogenesis.

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Claudin-1 expression in cervical cancer

Cited by 14 publications

References 9 publications

Claudins: New Players in Human Fertility and Reproductive System Cancers

Claudins: New Players in Human Fertility and Reproductive System Cancers

E7 oncoprotein from human papillomavirus 16 alters claudins expression and the sealing of epithelial tight junctions

Synergetic Effects of Intronic Mature miR-944 and ΔNp63 Isoforms on Tumorigenesis in a Cervical Cancer Cell Line

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