“…Since our main interest is to propose natural KDM4 inhibitors, we used the COlleCtion of Open Natural Products (COCONUT), which gathers 406,744 natural products from over 50 different databases, where nearly half the compounds come mainly from plants, fungi, bacteria, and to a lesser extent, from animal or marine origins ( Capecchi and Reymond, 2021 ; Sorokina et al, 2021 ). Most of these compounds ( Sorokina et al, 2021 ) have been used as traditional medicine in China, India (Ayurveda), Japan (Kampo), Korea, Mexico, among other countries ( Yuan et al, 2016 ; Gutiérrez-Rebolledo et al, 2017 ) and come from Asia, Africa, Brazil, and Mexico ( Sorokina et al, 2021 ).…”