Classification, regulation of activity, and genetic polymorphism of matrix metalloproteinases in health and disease

Shadrina, Alexandra S.; Плиева, Я. З.; Кушлинский, Д. Н.; Morozov, Alexei; Филипенко, М. Л.; Chang, V.; Кушлинский, Н. Е.

doi:10.18786/2072-0505-2017-45-4-266-279

Cited by 28 publications

(16 citation statements)

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“…Известно, что MMP играют роль в ремоделировании тканей, ангиоге незе, пролиферации и дифференциации клеток, апоптозе. Они задействованы в расщеплении мембранных рецепто ров, выбросе апоптозных лигандов, таких как FasL, в актива ции и деактивации хемокинов и цитокинов [33].…”

Section: Discussionunclassified

C-reactive protein and its associations with сardiometabolic risk factors and echocardiographic indicators of heart failure: results of “Know your heart” study in Arkhangelsk

et al. 2020

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Aim To evaluate the relationship between high-sensitivity C-reactive protein (hsCRP) and echocardiographic (EchoCG) indicators of heart failure (HF) among adult population of the North region of Russia.Material and methods The Know Your Heart transversal study was performed in 2015–2017 on a random sample of adult population of Arkhangelsk aged 35–69 years (n=2381). The exclusion criterion for this study was a concentration of hsCRP >10 mg/l. The group of subclinical inflammation included 686 participants with hsCRP ≥2.0 mg/l; the comparison group consisted of 1158 participants with hsCRP <2.0 mg/l. Analysis included cardiometabolic risk factors, EchoCG indexes of left ventricular (LV) systolic and diastolic function and biomarkers (NT-proBNP, hsTroponin Т, cystatin С). Linear and logistic regressions were used.Results The group with hsCRP ≥2.0 mg/l had higher rates of arterial hypertension, diabetes mellitus, HF, and myocardial infarction in history than the comparison group. The hsCRP level was independently associated with waist circumference (β=0.379, p <0.001), male gender (β=–0.135, p<0.001), smoking (β=0.109, p<0.001), triglycerides (β=0.083, p<0.001), diastolic blood pressure (β=0.082, p<0.001), cystatin C (β=0.082, p<0.001), glycated hemoglobin (β=0.064, p=0.003), and low-density lipoproteins (LDL) (β=0.049, p=0.025). Independent predictors of subclinical inflammation included older age, smoking, abdominal obesity, elevated values of LDL (>3.0 mmol/l), triglycerides (>1.7 mmol/l), and cystatin C (>1.2 mg/l). hsCRP was independently negatively associated with LV ejection fraction, left atrial volume index, ratio of early to late LV diastolic filling velocity (p=0.003, p=0.002, p=0.005, respectively), which reflected the relationship of the increased content of hsCRP with impairment of LV systolic and diastolic function. A relationship between heart remodeling indexes and hsCRP concentration was shown.Conclusion In a sample of adult population from the North region of Russia, the hsCRP concentration was independently associated with cardiometabolic risk factors and structural and functional changes in the heart detected by EchoCG, which reflects a potential contribution of inflammation to heart remodeling and development of HF.

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Section: Discussionunclassified

C-reactive protein and its associations with сardiometabolic risk factors and echocardiographic indicators of heart failure: results of “Know your heart” study in Arkhangelsk

et al. 2020

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“…За нашим припущенням, пригнічення активації AP-1, має покращити цілісність органічного матриксу кісток не тільки внаслідок зменшення експресії підконтрольного цьому транскрипційному чиннику гена iNOS, але і через зниження біосинтезу інших AP-1-залежних гістолітичних білків -матриксних металопротеїназ, прооксидантних сполук [26].…”

Section: результати дослідження та їх обговоренняunclassified

Effect of Ap-1 Transcription Factor Inhibitor on Structural, Metabolic and Biomechanical Changes in Bone Tissue During Combined Excessive Intake of Sodium Fluoride and Sodium Nitrate

Ковальова

Костенко

2019

Act. Probl. of the Modern Med.

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This article highlights the effect produced by the inhibitor of the AP-1 transcription factor activation on the mechanisms of structural, metabolic and biomechanical disorders in the femoral bones and vertebrae during combined excessive intake of sodium fluoride and sodium nitrate. The experiment was conducted on 30 white rats divided into 4 groups: the 1st included the intact animals, the 2nd group involved the rats subjected to the co- administration of sodium fluoride (10 mg / kg body weight) and sodium nitrate (500 mg / kg body weight) for 30 days, the 3rd group included the animals, which starting from the 15th day of intoxication, were injected SR 11302 ((E, E, Z, E) -3-Methyl-7- (4-methylphenyl) - 9- (2,6,6-trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenoic acid), an inhibitor of AP-1 activation in a dose of 1 mg / kg intraperitoneally 3 times a week. It has been revealed that the SR 11302 administration restores the mechanism of NO autoregulation in the femoral bones during the sodium fluoride and sodium nitrate co- administration, reducing the total activity of NO synthase and activity of its inducible isoform under a reciprocal increase in total arginase activity, and suppresses the peroxynitrite production. This is accompanied by a decrease in the activity of enzymes, which are known as markers of bone resorption (acid phosphatase and its bone isoform) and restriction of the depolymerization of collagen, proteoglycans and sialoglycoproteins of the connective (bone) tissue in the femurs and vertebrae. Moreover, the introduction of SR 11302 under the experimental conditions is accompanied by an increase in the density and mineral saturation of the femurs and vertebrae, and an improvement in the biomechanical characteristics of the femurs (their strength and elasticity).

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“…Several experimental studies had proven correlations between OA progression and accumulation of interstitial matrix metalloproteinases-1 (MMP-1) synthesized with chondrocytes as well as mesenchymal fibroblast gelatinizes (MMP-2) [4]. The crucial role in OA progression is played by the degradation of these collagen types, fibronectin, and aggrecan resulting from hyper MMP-7 [5]. In experimental AO simulations induced with papain injections in rabbits we determined the role of MMP-13 in the progression of collagen II and PGs loss involving β-catenin pathway [6].…”

Section: Introductionmentioning

confidence: 99%

The role of matrix metalloproteinases in early and late gonarthrosis manifestations

Гладкова

2020

Russ Open Med J

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The aim of this research was to study the specifics of the matrix metallopeptidase system in early and late gonarthrosis (GA) manifestations. Material and Methods — 37 patients of the main group (0-I stages of GA), 30 patients of the comparison group (III-IV stages of GA) and 30 healthy individuals of the control group underwent sonography and T2-relaxometry of their knee joints. The 24-h excretion of urinary C-telopeptide fragments of type II collagen (СTX-II) as well as serum concentrations of matrix metalloproteinases-3 and -8 (MMP-3, MMP-8), and tissue inhibitor of metalloproteinases (TIMP-1) were also registered. Results — We detected increases in urinary СTX-II to 3.9 [2.5; 4.5] mg/d, MMP-8 to 364.7 [215; 434] pg/ml and TIMP-1 to 806 [559; 1157] pg/ml in the main group; to 9.7 [6.8; 10.2] mg/d, 579 [463; 663] pg/ml and 1256 [1029; 1330] pg/ml in the comparison group. The presence (p=0.04) of strong positive correlation (R=0.7) between the 24-h urinary СTX-II excretion and the change of MRI-signal characteristics for the areas of hyaline cartilage under the heaviest load on knee joints T2 relaxometry evidence was observed as well as the presence (p=0.001) of strong positive correlation (R=0.7) between MMP-8 and 24-h urinary СTX-II extraction. In early GA stages a strong positive correlation (R=0.6) was observed between MMP-8 and TIMP-1 (p=0.04) as well as 24-h urinary СTX-II excretion and TIMP-1 (R=0.5) at p˂0.001). Conclusion — Type II collagen degradation with MMP-8/TIMP-1 imbalance is one of the relevant mechanisms of the hyaline articular cartilage extracellular matrix disorganization in early and late GA evidences. The rearrangement of correlations between MMP-8 and TIMP-1 indicates the change in interaction mechanisms for GA proteolytic enzyme system components.

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Classification, regulation of activity, and genetic polymorphism of matrix metalloproteinases in health and disease

Cited by 28 publications

References 1 publication

C-reactive protein and its associations with сardiometabolic risk factors and echocardiographic indicators of heart failure: results of “Know your heart” study in Arkhangelsk

C-reactive protein and its associations with сardiometabolic risk factors and echocardiographic indicators of heart failure: results of “Know your heart” study in Arkhangelsk

Effect of Ap-1 Transcription Factor Inhibitor on Structural, Metabolic and Biomechanical Changes in Bone Tissue During Combined Excessive Intake of Sodium Fluoride and Sodium Nitrate

The role of matrix metalloproteinases in early and late gonarthrosis manifestations

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