Classification of β‐adrenoceptors in isolated bronchus of the pig

Goldie, Roy G.; Paterson, J. W.; Wale, Janet

doi:10.1111/j.1476-5381.1983.tb10510.x

Cited by 12 publications

(9 citation statements)

References 17 publications

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“…Thus, highly selective fi-adrenoceptor agonists, such as procaterol, must be used to identify minor sub-populations of functional fi-adrenoceptors the presence of which may not be detected by studies using selective antagonists. In the mouse trachea, as previously shown in pig bronchus (Goldie et al, 1983), cat trachea (Lulich et al, 1976;O'Donnell & Wanstall, 1983) and rabbit trachea (Toda et al, 1978), #-adrenoceptor-mediated relaxation occurs predominantly through activation of #1-adrenoceptors. On the other hand, 1J2-adrenoceptors predominate in central airways preparations from guinea-pig (O'Donnell, 1972) and man (Goldie et al, 1984).…”

Section: Discussionsupporting

confidence: 58%

“…The results of the current (Goldie et al, 1983), dog coronary artery (O'Donnell & Wanstall, 1984), rat atria (Bryan et al, 1981) and guinea-pig atria (O'Donnell & Wanstall, 1979) where populations of fi1-adrenoceptors reportedly predominate. Conversely, in human isolated bronchus (Goldie et al, 1984) and guinea-pig trachea (O'Donnell & Wanstall, 1979) where #2-adrenoceptors predominate, noradrenaline was about one tenth as potent as fenoterol in mediating relaxation.…”

Section: Discussionmentioning

confidence: 52%

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β₁‐Adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea

Henry

Goldie

1990

British J Pharmacology

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 52%

β₁‐Adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea

Henry

Goldie

1990

British J Pharmacology

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“…Evidence from studies in conscious man strongly suggests a predominance of 12-adrenoceptors in central airways (Larsson & Svedmyr, 1977;Madsen et al, 1979). However, 13i-adrenoceptors predominate in the trachea of the cat (Lulich, et al, 1976;O'Donnell & Wanstall, 1983), rabbit (Bristow etal., 1970;Toda etal., 1978) and pig (Goldie et al, 1983) while 32-adrenoceptors predominate in guinea-pig trachea (O'Donnell 1972;O'Donnell & Wanstall, 1979). Harms (1976) has shown that f32-adrenoceptors predominate in isolated rings of human primary bronchi obtained from surgically excised lung samples.…”

Section: Introductionmentioning

confidence: 99%

Classification of β‐adrenoceptors in human isolated bronchus

Goldie

Paterson

Spina

et al. 1984

British J Pharmacology

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1(±)-Isoprenaline (Iso), (-)-adrenaline (Ad), (-)-noradrenaline (NA), (±)-phenylephrine (Phe) and the J2-selective adrenoceptor agonist (±)-fenoterol (Fen) caused a concentrationdependent relaxation of human isolated bronchial preparations. Iso, Ad 3 pA2 values determined for the 1-adrenoceptor antagonists propranolol (non-selective), atenolol (13-selective) and ICI-118, 551 (132-selective), using Iso as an agonist were, 9.3, 5.3 and 9.1 respectively. 4 These results indicate that 132-adrenoceptors mediate relaxation of human isolated bronchus to sympathomimetic amines in preparations obtained 4-14 h post-mortem from non-diseased lung. oa-Adrenoceptors were apparently sparse or absent in this tissue.

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“…The predominant subtype present in guinea-pig (O'Donnell, 1972;Zaagsma et al, 1983) and bovine (Lemoine et al, 1989) tissues is the P2 whereas in the pig (Goldie et al, 1983) and mouse ) the PI subtype predominate.…”

mentioning

confidence: 99%

Comparison of the effects of selective inhibitors of phosphodiesterase types III and IV in airway smooth muscle with differing β‐adrenoceptor subtypes

Tomkinson¹,

Karlsson²,

Raeburn³

1993

British J Pharmacology

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1 The relaxant properties of the type IV adenosine 3',5'-cyclic monophosphate phosphodiesterase (cyclic AMP PDE) inhibitor, rolipram and the P2-selective and non-selective P-adrenoceptor agonists salbutamol and isoprenaline, were compared on the guinea-pig, bovine, and mouse trachea and porcine bronchus all precontracted with methacholine (EC30).2 Rolipram and both P-agonists produced concentration-dependent reversal of the methacholineinduced tone in the four airway preparations.3 Isoprenaline and salbutamol were similar in potency on the guinea-pig 8.06) and bovine (-loglo IC50:8.52, 8.40) airways. In contrast, salbutamol was much less potent than isoprenaline on the mouse trachea (>1000 fold) and the porcine bronchus (>100 000 fold). 4 The potency of rolipram approached that of isoprenaline on the guinea-pig and bovine trachea (132-adrenoceptors predominate). However, rolipram was significantly less active than isoprenaline on the porcine bronchus (1000 fold) and mouse trachea (>2000 fold) where P2-adrenoceptors predominate.5 Siguazodan, the type III cyclic AMP PDE inhibitor, produced concentration-dependent relaxations of the porcine bronchus and guinea-pig trachea contracted with methacholine. Siquazodan was 100 fold more active than rolipram in pig tissues indicating the type III isoenzyme may be of greater functional significance in this tissue. In contrast, siguazodan was 15 times less potent that rolipram in guinea-pig airways suggesting a greater role for the type IV PDE.6 These findings may reflect a possible relationship between the P2-adrenoceptor subtype and the functional importance of the type IV PDE isoenzyme. A similar relationship may exist between P,-adrenoceptors and the PDE type III isoenzyme.

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Classification of β‐adrenoceptors in isolated bronchus of the pig

Cited by 12 publications

References 17 publications

β₁‐Adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea

β₁‐Adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea

Classification of β‐adrenoceptors in human isolated bronchus

Comparison of the effects of selective inhibitors of phosphodiesterase types III and IV in airway smooth muscle with differing β‐adrenoceptor subtypes

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Classification of β‐adrenoceptors in isolated bronchus of the pig

Cited by 12 publications

References 17 publications

β1‐Adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea

β1‐Adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea

Classification of β‐adrenoceptors in human isolated bronchus

Comparison of the effects of selective inhibitors of phosphodiesterase types III and IV in airway smooth muscle with differing β‐adrenoceptor subtypes

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Product

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β₁‐Adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea

β₁‐Adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea