Classification of toxicity of phenols to Tetrahymena pyriformis and subsequent derivation of QSARs from hydrophobic, ionization and electronic parameters

Zhao, Yuan H.; Yuan, Xing; Su, Li Ming; Qin, Wei C.; Abraham, Michael H.

doi:10.1016/j.chemosphere.2009.01.055

Cited by 33 publications

(25 citation statements)

References 25 publications

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“…Tetrahymena pyriformis [40], mixed bacterial cultures degrading phenolic compounds [44], etc. In general, these toxicity studies concluded that different diffusion rates through the cell membrane of the ionised and nonionised forms of the phenolic compounds resulted in different contributions to toxicity.…”

Section: Specific Anammox Activity Tests In the Presence Of Single Armentioning

confidence: 99%

“…As a result of accumulated lipophilic molecules, the membrane loses its integrity, and an increase in permeability of protons and ions can be observed [38]. The lipophilic character of a compound is equivalent to its hydrophobic character [39], which is normally represented by the logarithm of the octanol/water partition coefficient (pK OW ) [40].…”

Section: Specific Anammox Activity Tests In the Presence Of Single Armentioning

confidence: 99%

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Inhibition of the anammox activity by aromatic compounds

Ramos

Fernández

Suárez-Ojeda

et al. 2015

Chemical Engineering Journal

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The short-term effect of several aromatic compounds (o-cresol, p-nitrophenol, o-chlorophenol and quinoline) was evaluated over granular anammox sludge cultivated over 2 years in a Sequencing Batch Reactor (SBR). The anammox granular sludge had an average size of 1.0 ± 0.2 mm and was enriched in Brocadia sp. Specific Anammox Activity (SAA) batch tests with this granular biomass were carried out in the presence of o-cresol, p-nitrophenol, o-chlorophenol, quinoline and their mixtures. The anammox biomass was never exposed to the tested aromatic compounds, prior to the SAA tests. The concentration and the mixture of aromatic compounds had a strong effect over the loss of the anammox activity. The higher the concentrations of the aromatic compounds, the higher the reduction of the SAA. Quinoline and p-nitrophenol have a lower negative effect compared to o-cresol and ochlorophenol. The Luong inhibition model seems to adjust better the inhibition of anammox biomass by the tested aromatic compounds. Depending on the aromatic compound, toxic or inhibitory effect was measured. o-Cresol and o-chlorophenol caused a toxic effect whereas p-nitrophenol and quinoline produced an inhibitory effect. In general, synergistic effects were observed when mixtures of aromatic compounds were studied.

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Section: Specific Anammox Activity Tests In the Presence Of Single Armentioning

confidence: 99%

Section: Specific Anammox Activity Tests In the Presence Of Single Armentioning

confidence: 99%

Inhibition of the anammox activity by aromatic compounds

Ramos

Fernández

Suárez-Ojeda

et al. 2015

Chemical Engineering Journal

View full text Add to dashboard Cite

show abstract

“…(a) It is well established the toxicity dependence on pH of several phenolic ionisable compounds to different organisms like: Poecilia reticulata [14], Daphnia magna [15], Tetrahymena pyriformis [16]. In general, these toxicity studies concluded that the different diffusion rates through the cell membrane of the ionised and nonionised forms of the phenolic compounds resulted in different contributions to toxicity.…”

Section: Introductionmentioning

confidence: 97%

Modelling the pH dependence of the kinetics of aerobic p-nitrophenol biodegradation

Carrera

Martín-Hernández

Suárez-Ojeda

et al. 2011

Journal of Hazardous Materials

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“…A global QSAR model was developed by Cronin and Schultz for the prediction of the toxicity of phenols to T. pyriformis using 166 phenols [15], and the model was refined afterwards using 250 compounds (Cronin et al) [12]. Zhao et al used the same dataset and developed a QSAR model with hydrophobicity, ionization and electronic parameters [16] and later on with ionization and polarity of phenols [17]. In another QSAR study, Roy and coworkers have developed models for six different groups of aliphatic compounds such as alcohols, esters, acids, aldehydes, ketones and amines in order to provide a robust prediction of aliphatic toxicity against the T. pyriformis [18].…”

Section: Introductionmentioning

confidence: 99%