Classification of proliferative diabetic retinopathy

Piccolino, Felice Cardillo; Zingirian, M.; Mosci, Carlo

doi:10.1007/bf02150141

Cited by 25 publications

(21 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In diabetic retinopathy, neoangiogenesis may be preceded by the presence of acellular capillaries, in which pericytes and endothelial cells are absent. Our finding that acellular capillaries develop in the mid and peripheral retina of diabetic Ren-2 rats is consistent with our previous studies [24], and with observations in diabetic patients [33]. As rodents do not develop retinal neoangiogenesis, even after years of diabetes [34], we also studied OIR [22].…”

Section: Discussionsupporting

confidence: 91%

Aliskiren reduces vascular pathology in diabetic retinopathy and oxygen-induced retinopathy in the transgenic (mRen-2)27 rat

et al. 2011

View full text Add to dashboard Cite

Aim/hypothesis We examined whether the renin inhibitor, aliskiren, provides similar or greater protection than ACE inhibition from non-proliferative diabetic retinopathy and from the proliferative neoangiogenesis of oxygen-induced retinopathy. Methods Transgenic (mRen-2)27 rats, which overexpress mouse renin and angiotensin in extra-renal tissues, were studied. For diabetic studies, non-diabetic, diabetic (streptozotocin, 55 mg/kg), diabetic + aliskiren (10 mg kg −1 day −1 , pump), or diabetic + lisinopril (10 mg kg −1 day −1 , drinking water) rats were evaluated over 16 weeks. For oxygeninduced retinopathy studies, rats were exposed to 80% oxygen (22 h/day) from postnatal days 0 to 11, and then room air from postnatal days 12 to 18. Aliskiren (10 or 30 mg kg −1 day −1 , pump) or lisinopril (10 mg kg −1 day −1 , drinking water) was administered during retinopathy development between postnatal days 12 and 18. Results Systolic BP in diabetic (mRen-2)27 rats was reduced with 10 mg kg −1 day −1 aliskiren, but only lisinopril normalised systolic blood pressure. In diabetic (mRen-2)27 rats, 10 mg kg −1 day −1 aliskiren and lisinopril reduced retinal acellular capillaries and leucostasis to non-diabetic levels. In oxygen-induced retinopathy, neoangiogenesis and retinal inflammation (leucostasis, ED-1 immunolabelling) were partially reduced by 10 mg kg −1 day −1 aliskiren and normalised by 30 mg kg −1 day −1 aliskiren, whereas lisinopril normalised neoangiogenesis and reduced leucostasis and ED-1 immunolabelling. Aliskiren and lisinopril normalised retinal vascular endothelial growth factor expression; however, only aliskiren reduced intercellular adhesion molecule-1 to control levels. Conclusions/interpretation Aliskiren provided similar or greater retinal protection than ACE inhibition and may be a potential treatment for diabetic retinopathy.

show abstract

Section: Discussionsupporting

confidence: 91%

Aliskiren reduces vascular pathology in diabetic retinopathy and oxygen-induced retinopathy in the transgenic (mRen-2)27 rat

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Despite giving a valuable index of ischemia, information of the pattern of non-perfusion is lacking. It is important to understand the patterns of non-perfusion in retinal vascular diseases [19][20][21] . The concentric rings method incorporates this qualitative information whilst still providing comparable accuracy and intergrader agreement to the ischemic index method.…”

Section: Discussionmentioning

confidence: 99%

Validation of Concentric Rings Method as a Topographic Measure of Retinal Nonperfusion in Ultra-Widefield Fluorescein Angiography

Nicholson

Vázquez-Alfageme

Ramu

et al. 2015

American Journal of Ophthalmology

View full text Add to dashboard Cite

2 Structured Abstract Purpose:To validate the use of concentric rings as a method to measure topographical area of retinal non-perfusion in ultra wide-field angiography with the ischemic index method, which is the most frequently used method to measure non-perfusion in ultra widefield angiography. Design:Validation study and reliability analysis Methods:Setting: Single centre study performed at National Institute for Health Research Moorfields Biomedical Research Centre, London, United Kingdom.Study Population: 28 ultra wide-field angiogram images of eyes with central retinal vein occlusion.Observation Procedure: The concentric rings method consist of six macula centered concentric rings divided into 12 segments each. Each image was graded by five graders using both the concentric rings and the ischemic index methods. Main Outcome Measures:Agreement between the two methods was calculated using the intraclass correlation coefficient. Intertest agreement, intergrader agreement, test-retest reliability and the time taken to grade using these two methods were compared. Results:The intertest agreement between concentric rings method and ischemic index method was 0.965. The intergrader agreement was 0.910 for concentric rings method and 0.898 with the ischemic index method. The test-retest reliability was 0.975 for the rings and 0.979 for the ischemic index. Average grading time per image was 187s and 297s for concentric rings method and ischemic index method respectively, p=<0.001. Conclusion:The concentric rings method has an 'almost perfect' intergrader agreement and intertest agreement with the ischemic index method with a shorter grading time. Text IntroductionFundus fluorescein angiography (FA) remains the gold standard imaging tool for the measurement of retinal perfusion status in retinal vascular diseases. Previous seminal research papers such as the Early Treatment Diabetic Retinopathy Study 1 and the Central Vein Occlusion Study 2 classified retinal perfusion status based on the montage of overlapping 7-field FA images. However, 7-field imaging only allows visualisation of approximately a third of the retinal surface area. The acquisition of these 7-field images are also technically challenging and require well-trained photographers, well-dilated pupils and good patient co-operation to undergo multiple flash photography. Furthermore, a single 7-field montage image is formed of images acquired at different FA phases. These limitations have been overcome by the introduction of ultra wide-field imaging. The ultra wide-field imaging has a shorter image capture time and allows visualisation of significantly larger areas of the retina using less number of images compared to the conventional 7-field imaging. For example, the ultra wide-field image obtained by Optos Plc, Dumfermline, Scotland, United Kingdom covers approximately a 200 degree field of view in a single image compared to the 30 to 50 degree conventional fundus cameras and is now regularly used in clinical practice 3-9 .The conventional measurement of...

show abstract

“…Midperipheral capillary nonperfusion has been associated with focal macular edema. 15 In a recent study, capillary nonperfusion was detected in 84% of patients with clinically significant macular edema and nonproliferative retinopathy. 13 Ultrawide field FA allows detection of peripheral abnormalities of undetermined significance, including late leakage from peripheral vessels.…”

Section: Discussionmentioning

confidence: 98%

Ultrawide Angle Angiography for the Detection and Management of Diabetic Retinopathy

Kaines¹,

Oliver²,

Reddy³

et al. 2009

International Ophthalmology Clinics

View full text Add to dashboard Cite

Classification of proliferative diabetic retinopathy

Cited by 25 publications

References 9 publications

Aliskiren reduces vascular pathology in diabetic retinopathy and oxygen-induced retinopathy in the transgenic (mRen-2)27 rat

Aliskiren reduces vascular pathology in diabetic retinopathy and oxygen-induced retinopathy in the transgenic (mRen-2)27 rat

Validation of Concentric Rings Method as a Topographic Measure of Retinal Nonperfusion in Ultra-Widefield Fluorescein Angiography

Ultrawide Angle Angiography for the Detection and Management of Diabetic Retinopathy

Contact Info

Product

Resources

About