Classification of proanthocyanidin profiles using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) spectra data combined with multivariate analysis

Esquivel‐Alvarado, Daniel; Alfaro‐Viquez, Emilia; Krueger, Christian G.; Vestling, Martha M.; Reed, Jess D.

doi:10.1016/j.foodchem.2020.127667

Cited by 24 publications

(21 citation statements)

References 21 publications

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“…Indeed, unlike LC–MS instrumentations, the analysis performed via MALDI-TOF not only have unlimited mass range, but also higher sensitivity. Consequently, qualitative analyses on plant samples may include PACs with very high polymerization degrees [ 113 , 114 ]. However, quantification by MALDI-TOF is still a great challenge because pure analytical standards are not commercially available.…”

Section: Analytical Methods For the Identification And Quantification Of Proanthocyanidinsmentioning

confidence: 99%

“…These variations are equally present after consecutive laser shots in the same position or across different locations of the target surface. Finally, competitive ionization/ion suppression is an additional factor that hinders this kind of analysis, especially in complex samples such as plant material [ 114 ].…”

Section: Analytical Methods For the Identification And Quantification Of Proanthocyanidinsmentioning

confidence: 99%

“…Therefore, although MALDI-TOF allows to obtain a truly representative profile of PACs theoretically including all existing polymerization grades, quantifications through this MS technique is not recommended [ 114 ].…”

Section: Analytical Methods For the Identification And Quantification Of Proanthocyanidinsmentioning

confidence: 99%

“… Cluster distribution of proanthocyanidins in plant kingdom based on the total proanthocyanidin content according to previously published data [ 87 , 88 , 90 , 91 , 92 , 93 , 95 , 96 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 ]. Euclidean distances were calculated with the average linkage method.…”

Section: Figurementioning

confidence: 99%

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Proanthocyanidins and Where to Find Them: A Meta-Analytic Approach to Investigate Their Chemistry, Biosynthesis, Distribution, and Effect on Human Health

et al. 2021

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Proanthocyanidins (PACs) are a class of polyphenolic compounds that are attracting considerable interest in the nutraceutical field due to their potential health benefits. However, knowledge about the chemistry, biosynthesis, and distribution of PACs is limited. This review summarizes the main chemical characteristics and biosynthetic pathways and the main analytical methods aimed at their identification and quantification in raw plant matrices. Furthermore, meta-analytic approaches were used to identify the main plant sources in which PACs were contained and to investigate their potential effect on human health. In particular, a cluster analysis identified PACs in 35 different plant families and 60 different plant parts normally consumed in the human diet. On the other hand, a literature search, coupled with forest plot analyses, highlighted how PACs can be actively involved in both local and systemic effects. Finally, the potential mechanisms of action through which PACs may impact human health were investigated, focusing on their systemic hypoglycemic and lipid-lowering effects and their local anti-inflammatory actions on the intestinal epithelium. Overall, this review may be considered a complete report in which chemical, biosynthetic, ecological, and pharmacological aspects of PACs are discussed.

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Section: Analytical Methods For the Identification And Quantification Of Proanthocyanidinsmentioning

confidence: 99%

Section: Analytical Methods For the Identification And Quantification Of Proanthocyanidinsmentioning

confidence: 99%

Section: Analytical Methods For the Identification And Quantification Of Proanthocyanidinsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Proanthocyanidins and Where to Find Them: A Meta-Analytic Approach to Investigate Their Chemistry, Biosynthesis, Distribution, and Effect on Human Health

et al. 2021

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“…It was demonstrated [99] that anthocyanins profiles of the berry skins of 23 red grape varieties can be easily and rapidly obtained by MALDI-TOF, enabling the identification of several varietal traits useful for the differentiation of authentic cultivars from hybrid ones on a molecular basis. Very recently, proanthocyanidin profiles of different fruit skins were obtained [100] by MALDI-TOF coupled to multivariate analysis, which proved to be a useful tool to evaluate authenticity in mixtures of different proanthocyanidin.…”

Section: Fruits and Vegetablesmentioning

confidence: 99%

MALDI-TOF Mass Spectrometry Applications for Food Fraud Detection

Zambonin

2021

Applied Sciences

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Chemical analysis of food products relating to the detection of the most common frauds is a complex task due to the complexity of the matrices and the unknown nature of most processes. Moreover, frauds are becoming more and more sophisticated, making the development of reliable, rapid, cost-effective new analytical methods for food control even more pressing. Over the years, MALDI-TOF MS has demonstrated the potential to meet this need, also due to a series of undeniable intrinsic advantages including ease of use, fast data collection, and capability to obtain valuable information even from complex samples subjected to simple pre-treatment procedures. These features have been conveniently exploited in the field of food frauds in several matrices, including milk and dairy products, oils, fish and seafood, meat, fruit, vegetables, and a few other categories. The present review provides a comprehensive overview of the existing MALDI-based applications for food quality assessment and detection of adulterations.

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Analysis of Proanthocyanidins in Food Ingredients by the 4‐(Dimethylamino)cinnamaldehyde Reaction

Esquivel‐Alvarado

Alfaro‐Viquez

Birmingham³

et al. 2023

Recent Advances in Polyphenol Research

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Classification of proanthocyanidin profiles using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) spectra data combined with multivariate analysis

Cited by 24 publications

References 21 publications

Proanthocyanidins and Where to Find Them: A Meta-Analytic Approach to Investigate Their Chemistry, Biosynthesis, Distribution, and Effect on Human Health

Proanthocyanidins and Where to Find Them: A Meta-Analytic Approach to Investigate Their Chemistry, Biosynthesis, Distribution, and Effect on Human Health

MALDI-TOF Mass Spectrometry Applications for Food Fraud Detection

Analysis of Proanthocyanidins in Food Ingredients by the 4‐(Dimethylamino)cinnamaldehyde Reaction

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