Classification of oligodendroglial tumors based on histopathology criteria is a significant predictor of survival – clinical, radiological and pathologic long-term follow-up analysis

Sánchez, Jose M.; Montero, José María; Diez-Lobato, R.; Hernández-Laín, Aurelio; Cabello, A; Ramos, Ana Pilar; Leon, P.; Campo, José Ramón Ricoy

doi:10.5414/npp28011

Cited by 8 publications

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“…Spectroscopy detects metabolic changes related to the levels of choline, myo-inositol and acetylaspartate acid in low-grade tumors, and also the presence of lipids and lactates in high-grade tumors 1,21 . Immunohistochemistry and molecular biology, with chromosome 1p and 19q evaluation, are currently important predictive and prognostic factors in histopathological diagnosis 1,6,19 .…”

Section: Introductionmentioning

confidence: 99%

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Our Experience in Brain Oligodendroglioma Management in Adults

Suárez¹,

Herrera²,

Surur³

et al. 2018

jbnc

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Objective: to present our 19 years’ experience in the management of oligodendroglioma brain tumors in adults. Materials and Methods: From a series of 505 adult patients with brain tumors operated on from January 1991 to December 2009, 30 cases (5.9%) were histopathologically diagnosed as oligodendrogliomas. Twenty-six of them achieved a good follow-up. Results: from the 26 patients, the age ranged between 23 and 72 years. Histological diagnosis showed pure oligodendrogliomas in 17 patients and 9 cases of oligoastrocytomas. Ki-67 immunohistochemistry was performed in 23 patients: in 16 positivity was less than or equal to 5% and in 7 it was greater than 5%. Chromosomes 1p and 19q were studied in 12 patients with positive co-deletion in 2 and negative in the other 10. Twenty patients were operated on,3 received radiation therapy and chemotherapy, and 1 brachytherapy with Iodine-125 and two were not operated on (because the diagnosis was incidental, the tumor was small and was located in the motor area). Currently, 19 patients are alive (73%) and 7 died (27%). Mean survival time of the deceased patients was 7 years and 2 months and a median of 5 years and 8 months. Conclusion: it is not possible to make statistical analysis because small number of cases, although total removal seems to be the best treatment option, due to our small series of cases, we hope randomized double-blinded future studies will clear up the best choice of diagnosis and treatment.

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confidence: 99%

“…Neuropathological studies include microscopy and immunohistochemistry: histological characteristics that are associated with patient's survival are high cellularity, mytosis, endothelial proliferation and necrosis 8,19 . Immunohistochemical study of these tumors shows a prognostic value for Ki-67 (MIB-1) greater than 5% 3,5,11 .…”

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confidence: 99%

Our Experience in Brain Oligodendroglioma Management in Adults

Suárez¹,

Herrera²,

Surur³

et al. 2018

jbnc

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Hypoxia-inducible factor-1-regulated protein expression and oligodendroglioma patient outcome: comparison with established biomarkers and preoperative UCSF low-grade scoring system

Abraham

Jensen

2012

J Neurooncol

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Methods for predicting outcome for patients with oligodendrogliomas and anaplastic oligodendrogliomas (AOs) are limited. Hypoxia-inducible factor-1α (HIF-1α) controls many proteins involved in glycolysis and angiogenesis including VEGF, Glut-1, and CA-IX. We examined whether expression of HIF-1α and other hypoxia-regulated molecules (HRM) can predict overall (OS) and progression-free (PFS) survival. We correlated these data with more established biomarkers and a published preoperative scoring system. We prospectively collected tissue samples and followed outcomes of 50 patients with oligodendrogliomas and 32 with AOs. Tumor tissues were stained for measures of proliferative index, microvascular density, IDH-1 mutational status, and HRMs. We retrospectively analyzed preoperative imaging and clinical data based on the UCSF Scoring System (good prognostic indicators: Karnofsky Performance Scale (KPS) score > 80, age < 50 years, tumor diameter < 4 cm, noneloquent tumor location) and correlated these with immunohistochemical markers, 1p19q chromosomal status, and compared both with patient PFS and OS. Mean follow-up was 85.6 ± 41.4 months. HRMs showed higher expression in AOs than in oligodendrogliomas. Both 1p19q codeletion and IDH-1 mutation predict outcome of patients with both oligodendroglioma and AO. The UCSF score is a strong predictor for oligodendrogliomas patient outcome and is strengthened by IDH-1 and 1p19q status. Glut-1 may be useful in predicting PFS in AOs. Proliferation index >5 for oligodendrogliomas and KPS ≤ 80 for AOs predict a worse prognosis. Immunohistochemical markers of HRMs show a significantly higher expression in anaplastic variants of oligodendrogliomas and may contribute to the prediction of survival in these patients.

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Oligodendroglioma

2016

Diagnostic Imaging: Brain

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Classification of oligodendroglial tumors based on histopathology criteria is a significant predictor of survival – clinical, radiological and pathologic long-term follow-up analysis

Cited by 8 publications

References 0 publications

Our Experience in Brain Oligodendroglioma Management in Adults

Our Experience in Brain Oligodendroglioma Management in Adults

Hypoxia-inducible factor-1-regulated protein expression and oligodendroglioma patient outcome: comparison with established biomarkers and preoperative UCSF low-grade scoring system

Oligodendroglioma

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