Classification of odontogenic cysts and tumors – Antecedents

Imran, Aesha; Jayanthi, P; Tanveer, Shahela; Gobu, Sreeja C

doi:10.4103/0973-029x.185935

Cited by 19 publications

(13 citation statements)

References 8 publications

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“…Some originate from the remnants of odontogenic epithelium that are laid down after the completion of tooth development while others develop from the malignant transformation of a cyst or tumor. [8] ACA is a rare entity that is challenging to diagnose, especially when spindle cells are present in a conventional SMA. In addition, there are no standardized microscopic criteria to distinguish ACA histopathologically from aggressive SMA.…”

Section: Discussionmentioning

confidence: 99%

Stem Cell Markers SOX-2 and OCT-4 Enable to Resolve the Diagnostic Dilemma between Ameloblastic Carcinoma and Aggressive Solid Multicystic Ameloblastoma

et al. 2018

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Background:Ameloblastic carcinoma (ACA) is a malignant neoplasm with overlapping histopathological features of benign aggressive solid multicystic ameloblastoma (SMA). This often leads to misdiagnosis with direct implication on the management protocol. The need of the hour is to adopt reliable tissue biomarkers to differentiate these lesions accurately that will help to implement an appropriate treatment modality. Few studies to differentiate ACA and SMA in literature with a limitation of a single marker and lack of availability of cases have prompted us to undertake this study. Thereby, this study is aimed at resolving the diagnostic dilemma in differentiating ACA and aggressive SMA using SOX-2, OCT-4 and CD44.Materials and Methods:Tissue samples involved 40 archival cases of histopathologically confirmed cases of ACA (n = 20) and SMA (n = 20). The sections were subjected to immunohistochemical staining using antibodies to SOX-2, OCT-4 and CD44. Nuclear staining for SOX-2 and OCT-4 and membranous reactivity for CD44 was considered positive.Results:The expression of SOX-2 and OCT-4 in ACA was statistically significant when compared to SMA (P < 0.001). CD44 showed an insignificant statistical value of <0.077 in differentiating ACA and SMA. SOX-2 and OCT-4 expression in ACA showed a significant correlation coefficient of 0.616 at P < 0.004.Conclusions:SOX-2 and OCT-4 could serve as independent novel markers in resolving the diagnostic dilemma between ACA and aggressive SMA.

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Section: Discussionmentioning

confidence: 99%

Stem Cell Markers SOX-2 and OCT-4 Enable to Resolve the Diagnostic Dilemma between Ameloblastic Carcinoma and Aggressive Solid Multicystic Ameloblastoma

et al. 2018

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“…Se incluyeron historias clínicas de pacientes institucionalizados con diagnóstico definitivo de quiste odontogénico confirmado con el estudio histopatológico y la información pertinente al estudio se encontrará registrada de manera completa en la historia clínica. Los datos evaluados fueron: Edad agrupada en rangos de (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), (20-30) y (30-inf), sexo (masculino y femenino) y localización del quiste (maxilar anterior, maxilar posterior, mandibular anterior, mandibular posterior).…”

Section: Materiales Y Métodosunclassified

Frecuencia de quistes odontogénicos en pacientes de la Facultad de Odontología, Universidad Nacional de Colombia

Fajardo-Ortiz

Vega

2018

Univ Odontol

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Antecedentes: Los quistes odontogénicos se caracterizan por ser asintomáticos. Su hallazgo depende en un 80 % de imágenes radiográficas y en un 20 % de sintomatología esporádica. Colombia presenta pocos datos epidemiológicos sobre esta patología. Objetivo: Describir la frecuencia de los quistes odontogénicos, según la clasificación de la OMS del 2017, en los pacientes de la Facultad de Odontología de la Universidad Nacional de Colombia, sede Bogotá. Métodos: Se realizó un estudio descriptivo de corte transversal. Se seleccionaron historias clínicas con diagnóstico de quiste odontogénico corroborado por análisis histopatológico, y que tuvieran correctamente diligenciados los datos de edad, sexo y localización (zona afectada). Se usó la prueba de Fisher para evaluar independencia entre variables (p=0,05). Resultados: Los quistes odontogénicos más frecuentes fueron: quiste dentígero (66,6 %), quiste radicular (22,2 %) y queratoquiste odontogénico (11,2%). El 77,7 % se diagnosticó en hombres. 38.9 % de ellos se diagnosticaron entre la primera y segunda décadas de la vida (p=0,041) y la zona posterior mandibular fue la más afectada en un 44,4 % (p=0,017). Conclusiones: El quiste dentígero se presentó más durante la segunda década de la vida, en hombres y en la zona mandibular posterior. El quiste radicular no mostró predilección por un sexo, se presentó durante y después de la cuarta década de la vida y afectó la zona maxilar anterior. El queratoquiste odontogénico no tuvo predilección por sexo o zona afectada y se presentó en dos décadas de la vida diferentes.

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“…The development of the lesion may be mild, long-term or aggressive and rapid, infiltration of adjacent tissues and presence of satellite microcysts are also possible. The growth of OKC is usually asymptomatic, so it is often discovered incidentally during radiographic examinations performed for other reasons [ 6 – 10 ]. The treatment of choice should be done with complete enucleation of the lesion with possible extension of the procedure to peripheral bone curettage, decompression, marsupialisation, application of Carnoy's fluid or cryodestruction.…”

Section: Introductionmentioning

confidence: 99%

Multiple odontogenic keratocysts in Ehlers–Danlos syndrome: a rare case report

et al. 2021

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Background An odontogenic keratocyst is a lesion characterized by aggressive and infiltrative growth. The lesion is characterized by the existence of satellite microcysts (microtumours) and frequent recurrence (up to 30%). Ehlers–Danlos syndrome is a condition in which collagen production or its post-translational modifications are affected. Defects in connective tissues cause symptoms, which range from mild joint hypermobility to life-threatening complications. Case presentation We present an extremely rare case of an 11-year old girl with Ehlers–Danlos syndrome and coexistence of multiple odontogenic keratocysts. Conclusions This case shows mainly atypical or rare association between multiple odontogenic keratocysts and Ehlers–Danlos syndrome.

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Classification of odontogenic cysts and tumors – Antecedents

Cited by 19 publications

References 8 publications

Stem Cell Markers SOX-2 and OCT-4 Enable to Resolve the Diagnostic Dilemma between Ameloblastic Carcinoma and Aggressive Solid Multicystic Ameloblastoma

Stem Cell Markers SOX-2 and OCT-4 Enable to Resolve the Diagnostic Dilemma between Ameloblastic Carcinoma and Aggressive Solid Multicystic Ameloblastoma

Frecuencia de quistes odontogénicos en pacientes de la Facultad de Odontología, Universidad Nacional de Colombia

Multiple odontogenic keratocysts in Ehlers–Danlos syndrome: a rare case report

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