“…Conventionally, the values of control variables corresponding to the steady state values are set to the columns for startup and one just waits for columns running to the desired steady state (so called direct setting strategy). Empirical startup strategies like total or zero reflux flow and maximum reboiler duty for single columns have been proposed [1,2,3] to improve the startup performance. Since a column startup is influenced by many factors such as column structure, type of trays and packings, components in the mixture to be separated as well as top and bottom specifications, these empirical strategies are suitable only for some specific cases.…”