One of the tools that can aid researchers and clinicians in coping with the surfeit of biomedical information is text mining. In this chapter, we explore how text mining is used to perform biomedical knowledge extraction. By describing its main phases, we show how text mining can be used to obtain relevant information from vast online databases of health science literature and patients' electronic health records. In so doing, we describe the workings of the four phases of biomedical knowledge extraction using text mining (text gathering, text preprocessing, text analysis, and presentation) entailed in retrieval of the sought information with a high accuracy rate. The chapter also includes an in depth analysis of the differences between clinical text found in electronic health records and biomedical text found in online journals, books, and conference papers, as well as a presentation of various text mining tools that have been developed in both university and commercial settings.