1997
DOI: 10.1507/endocrj.44.501
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Classification of Hypothalamic Progestin-Nonresponsive Amenorrhea by Secretion Pattern of Serum LH.

Abstract: The pathogenesis of hypothalamic progestin-nonresponsive amenorrhea is unclear and this disease often fails to respond to treatment. The pulsatile patterns of diurnal and nocturnal secretion of serum LH as well as serum levels of melatonin were examined to improve the understanding of the pathogenesis and to develop strategies for the management of a severe type of hypothalamic amenorrhea. Four types of LH pulsatile patterns were observed: a) no pulse during the day or night (Group 1); b) more than 1 pulse onl… Show more

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