Classification of Hydrogels Based on Their Source: A Review and Application in Stem Cell Regulation

Khansari, Maziyar M.; Sorokina, Lioudmila V.; Mukherjee, Prithviraj; Mukhtar, Farrukh; Shirdar, Mostafa Rezazadeh; Shahidi, Mahnaz; Shokuhfar, Tolou

doi:10.1007/s11837-017-2412-9

Cited by 44 publications

(34 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Naturally occurring systems are mainly based on polymeric materials of agarose, alginates, gelatin, fibrin, hyaluronic acid or collagen; for example, with applications in the differentiation of human embryonic stem cells. 135 Synthetic or man-made polymers, despite being more inert than the natural occurring polymeric materials, bear the advantage of longer shelf-life with a greater retention capacity and can easily be modified further. 136 This provides a better platform for the incorporation of drugs into hydrogel carriers or improvements in tissue engineering.…”

Section: Classification Of Hydrogelsmentioning

confidence: 99%

Hydrogels: soft matters in photomedicine

Khurana

Gierlich

Meindl

et al. 2019

Photochem Photobiol Sci

View full text Add to dashboard Cite

show abstract

Section: Classification Of Hydrogelsmentioning

confidence: 99%

Hydrogels: soft matters in photomedicine

Khurana

Gierlich

Meindl

et al. 2019

Photochem Photobiol Sci

View full text Add to dashboard Cite

show abstract

“…In addition to biocompatibility, PEG-based hydrogels are also utilized for their structural support 60 and ease of functionalization. 61 Studies focused on artificial ovarian tissue delivery have shown encapsulated immature ovarian follicles in PEG-RGD hydrogels can enhance primordial follicle development and graft survival compared to non-encapsulated follicles. 62 After a subcutaneous transplant of encapsulated ovarian tissue, ovariectomized adult mice showed restoration of the estrous cycle within two weeks.…”

Section: Cell Delivery In Encapsulating Hydrogelsmentioning

confidence: 99%

It’s All in the Delivery: Designing Hydrogels for Cell and Non-viral Gene Therapies

et al. 2018

View full text Add to dashboard Cite

Hydrogels provide a regenerative medicine platform with their ability to create an environment that supports transplanted or endogenous infiltrating cells and enables these cells to restore or replace the function of tissues lost to disease or trauma. Furthermore, these systems have been employed as delivery vehicles for therapeutic genes, which can direct and/or enhance the function of the transplanted or endogenous cells. Herein, we review recent advances in the development of hydrogels for cell and non-viral gene delivery through understanding the design parameters, including both physical and biological components, on promoting transgene expression, cell engraftment, and ultimately cell function. Furthermore, this review identifies emerging opportunities for combining cell and gene delivery approaches to overcome challenges to the field.

show abstract

“…In comparison to natural sources of hydrogels, synthetic sources have better mechanical strength but a slower degradation rate. However, they are not biocompatible in vivo, unlike natural hydrogels [ 9 , 12 , 13 ]. Hydrogels can also be divided depending on the presence or absence of electrical charge in the polymeric chain.…”

Section: Introductionmentioning

confidence: 99%

“…The materials used in the hydrogel manufacturing process include both natural and synthetic polymers, as well as hybrid hydrogels, which involve combinations of natural and synthetic polymers [ 2 , 12 ]. These natural polymers can be obtained from natural sources such as plants, bacterial cultures, or animals, including polysaccharides (e.g., agarose, alginate, carrageenan, chitosan), glycosaminoglycans (e.g., heparin, hyaluronic acid, keratan sulfate), and polypeptides or proteins (e.g., collagen, fibrin, gelatin, silk).…”

Section: Introductionmentioning

confidence: 99%

“…The properties of hydrogels, such as their soft structures, elasticity, and similarity to living tissues, make them excellent for tissue engineering and regenerative medicine applications, as well as in stem cell cultures and cell implantation. Tissues and organs in the human body are characterized by their unique structures, differing in water content, as well as their mineral and protein contents, therefore it is necessary to use a biopolymer to manufacture a hydrogel with common building blocks [ 2 , 5 , 6 , 12 ]. Hydrogels are excellent materials for the production of substrates for cell cultures, for example three-dimensional porous scaffolds that can imitate the extracellular matrix (ECM), ensuring cell proliferation and differentiation in the in vitro microenvironment.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Review on the Adaption of Alginate-Gelatin Hydrogels for 3D Cultures and Bioprinting

et al. 2021

View full text Add to dashboard Cite

Sustaining the vital functions of cells outside the organism requires strictly defined parameters. In order to ensure their optimal growth and development, it is necessary to provide a range of nutrients and regulators. Hydrogels are excellent materials for 3D in vitro cell cultures. Their ability to retain large amounts of liquid, as well as their biocompatibility, soft structures, and mechanical properties similar to these of living tissues, provide appropriate microenvironments that mimic extracellular matrix functions. The wide range of natural and synthetic polymeric materials, as well as the simplicity of their physico-chemical modification, allow the mechanical properties to be adjusted for different requirements. Sodium alginate-based hydrogel is a frequently used material for cell culture. The lack of cell-interactive properties makes this polysaccharide the most often applied in combination with other materials, including gelatin. The combination of both materials increases their biological activity and improves their material properties, making this combination a frequently used material in 3D printing technology. The use of hydrogels as inks in 3D printing allows the accurate manufacturing of scaffolds with complex shapes and geometries. The aim of this paper is to provide an overview of the materials used for 3D cell cultures, which are mainly alginate–gelatin hydrogels, including their properties and potential applications.

show abstract

Classification of Hydrogels Based on Their Source: A Review and Application in Stem Cell Regulation

Cited by 44 publications

References 69 publications

Hydrogels: soft matters in photomedicine

Hydrogels: soft matters in photomedicine

It’s All in the Delivery: Designing Hydrogels for Cell and Non-viral Gene Therapies

A Review on the Adaption of Alginate-Gelatin Hydrogels for 3D Cultures and Bioprinting

Contact Info

Product

Resources

About