Classification of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma Based on Radiomic Analysis

Abstract

Introduction. Considering the narrow window of surgery, early diagnosis of liver cancer is still a fundamental issue to explore. Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICCA) are considered as two different types of liver cancer because of their distinct pathogenesis, pathological features, prognosis, and responses to adjuvant therapies. Qualitative analysis of image is not enough to make a discrimination of liver cancer, especially early-stage HCC or ICCA. Methods. This retrospective study developed a radiomic-based model in a training cohort of 122 patients. Radiomic features were extracted from computed tomography (CT) scans. Feature selection was operated with the least absolute shrinkage and operator (LASSO) logistic method. The support vector machine (SVM) was selected to build a model. An internal validation was conducted in 89 patients. Results. In the training set, the AUC of the evaluation of the radiomics was 0.855 higher than for radiologists at 0.689. In the valuation cohorts, the AUC of the evaluation was 0.847 and the validation was 0.659, which indicated that the established model has a significantly better performance in distinguishing the HCC from ICCA. Conclusion. We developed a radiomic diagnosis model based on CT image that can quickly distinguish HCC from ICCA, which may facilitate the differential diagnosis of HCC and ICCA in the future.

The Application Value of MRI T 2 ∗ WI Radiomics Nomogram in Discriminating Hepatocellular Carcinoma from Intrahepatic Cholangiocarcinoma

“…Their symptoms, serum tumor markers, and imaging manifestations have differences as well as similarities. Although it has been reported that radiologic diagnostic models based on CT and MRI images can rapidly differentiate HCC from ICCA [ 3 , 4 ], especially noncontrast MRI which is difficult for radiologists to correctly distinguish them accordingly, so far, there is no relevant literature report on noncontrast MRI based on T2 ∗ WI to differentiate ICCA from HCC. Therefore, it would be of great benefit to both doctors and patients to discover a method to identify different types of primary hepatic carcinoma on non-contrast-enhanced MRI scans.…”

Personalized intrahepatic cholangiocarcinoma prognosis prediction using radiomics: Application and development trend

“…Qualitative image analysis is not sufficient to differentiate between HCC or ICC. Xu et al ( 48 ). developed a diagnostic model based on CT images to provide a reference for future differential diagnosis of HCC and ICC.…”

Rapid label-free detection of cholangiocarcinoma from human serum using Raman spectroscopy

“…Thus, these techniques can present a challenge in poor-resource settings. The experience level of radiologists could also compromise the accuracy of diagnosis and the frequency of misdiagnoses [58].…”