Classification of Fundus Autofluorescence Patterns in Early Age-Related Macular Disease

Bindewald, A.; Bird, Alan C.; Dandekar, Samantha S.; Dolar-Szczasny, Joanna; Dreyhaupt, Jens; Fitzke, F.W.; Einbock, W.; Holz, Frank G.; Jorzik, Jork J.; Keilhauer, Claudia N.; Lois, Noemi; Mlynski, J.; Pauleikhoff, Daniel; Staurenghi, Giovanni; Wolf, Sebastian

doi:10.1167/iovs.04-0430

Cited by 219 publications

(215 citation statements)

References 31 publications

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“…8,9 Several studies concluded that FAF imaging in dry ARMD does not necessarily correspond to the fundus changes observed, yet provides information over and above the normal fundus photography methods used. 8,10 Active stages of acute central serous retinopathy (CSR) show an increase in FAF corresponding to increased metabolic activity of the retinal pigment epithelium (RPE), while chronic CSR shows decreased FAF probably due to the reduced metabolic activity of the RPE secondary to photoreceptor cell loss. 11 In pseudoxanthoma elasticum and atrophic ARMD, atrophy of the RPE is associated with decreased FAF.…”

Section: Introductionmentioning

confidence: 99%

Changes in fundus autofluorescence of choroidal melanomas following treatment

Amselem

Pulido

Günduz

et al. 2007

Eye

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Purpose We have previously shown that fundus autofluorescence (FAF) associated with pigmented choroidal lesions can be attributed to mainly lipofuscin (orange pigment) but also to hyperpigmentation, drusen, or fibrous metaplasia. The purpose of this study is to describe the effects of treatment on FAF in choroidal melanomas after plaque radiotherapy alone or in combination with transpupillary thermotherapy (TTT). Methods Retrospective chart review of eight consecutive patients with choroidal melanoma treated with plaque radiotherapy alone or in combination with TTT who underwent FAF photography before and after treatment. The correlation between FAF patterns and foci of orange pigment, hyperpigmentation, drusen, or fibrous metaplasia was evaluated. Results The median follow-up time was 4 (range 2-9) months. Foci of orange pigment and hyperpigmentation became larger and more numerous after treatment. Fibrous metaplasia was also increased. A complete correlation between increased FAF and orange pigment was found in all eight tumours (100%) before and after treatment. No correlation between hyperpigmentation and increased FAF was found before treatment but a partial correlation was found in all eyes after treatment. Before treatment, correlation between fibrous metaplasia was present in three eyes and increased FAF was partial in two eyes with no correlation in one case. After treatment, this correlation was partial in all presenting eyes (7). Conclusions Following treatment, choroidal melanomas may show increased FAF, mainly due to an increase in the amount of lipofuscin (orange pigment) and hyperpigmentation.

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Section: Introductionmentioning

confidence: 99%

Changes in fundus autofluorescence of choroidal melanomas following treatment

Amselem

Pulido

Günduz

et al. 2007

Eye

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“…The peri-lesion hyperfluorescence observed in exudative wet AMD is lower than that observed in classic wet AMD. FAF usually increases in various diseases, leading to disordered RPE metabolism and the accumulation of lipofuscin, followed by increased fluorescence (Bindewald et al, 2005a). The high fluorescence signal at the edge of CNV lesions indicates that the accumulation of lipofuscin is significant.…”

Section: Discussionmentioning

confidence: 99%

Fundus autofluorescence in exudative age-related macular degeneration

Peng

Dong²,

Zhao³

2013

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to investigate the characteristics of fundus autofluorescence (FAF) in patients with wet (exudative) age-related macular degeneration (AMD). Color fundus photographs, fundus fluorescein angiograms, indocyanine green angiograms, and FAF images were obtained from 61 patients (72 eyes) with exudative AMD. The FAF results for different patterns of exudative AMD were compared to those revealed by other fundus images. Of the 72 eyes evaluated, which were classified into three patterns based on the results of fundus fluorescein angiography, 68 had abnormal FAF. Forty-six eyes (63.9%) had classic wet AMD with abnormal FAF. Among these, 10 exhibited a slightly decreased FAF with near-normal or background FAF signal at the center of the lesion area; 36 demonstrated not only decreased FAF at the center of the lesion but also an increased FAF signal toward the lesion edge. Sixteen eyes (22.2%) had occult wet AMD, of which 12 exhibited heterogeneous fluorescence at the lesion site; 4 yielded normal FAF images. Ten eyes (13.9%) had a mixed pattern of wet AMD with abnormal FAF. FAF imaging suggested that the areas Exudative age-related macular degeneration of blood and exudates decreased; however, fluorescence angiography revealed that lesions with hyperfluorescence had background or slightly increased FAF. These results showed that various patterns of wet AMD exhibit different autofluorescence characteristics. These represent the functional and metabolic features of retinal pigment epithelial cells. Therefore, FAF can be used to monitor disease development and evaluate the severity and prognosis of AMD.

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“…For patients with advanced AMD, the diffuse and banded FAF patterns in the junctional zone of GA appear to be precursors to expansion. 18,52,72 Newer studies investigating the association between reticular drusen, reticular FAF pattern, and advanced AMD indicate that reticular macular disease is another important risk factor for disease progression. as small as 2 μm.…”

Section: Autofluorescencementioning

confidence: 99%

Scanning Laser Ophthalmoscope in the Management of Age-related Macular Degeneration

Scripsema¹,

Rosen²

2012

US Ophthalmic Review

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Recent advances in retinal imaging have improved the evaluation and prognostication of age-related macular degeneration. The development and modification of the scanning laser ophthalmoscope (SLO) has played a pivotal role in our understanding of the disease. SLO has led to improved methods of visualizing characteristics of the disease, such as drusen and alterations in autofluorescence, and also provided a platform for the quantification of structural and functional changes occurring as a result of the disease process. This article provides a review of the current literature on the impact and clinical utility of SLO devices for infrared viewing, fundus autofluorescence, microperimetry, and as integraded multimodal imaging systems such as optical coherence tomography and SLO.

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Classification of Fundus Autofluorescence Patterns in Early Age-Related Macular Disease

Cited by 219 publications

References 31 publications

Changes in fundus autofluorescence of choroidal melanomas following treatment

Changes in fundus autofluorescence of choroidal melanomas following treatment

Fundus autofluorescence in exudative age-related macular degeneration

Scanning Laser Ophthalmoscope in the Management of Age-related Macular Degeneration

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