Classification of cutaneous malignant melanoma

Weyers, Wolfgang; Euler, M.; Díaz‐Cascajo, Carlos; Schill, Wolf‐Bernhard; Bonczkowitz, Matthias

doi:10.1002/(sici)1097-0142(19990715)86:2<288::aid-cncr13>3.0.co;2-s

Cited by 77 publications

(15 citation statements)

References 31 publications

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“…Melanoma subtype was based on the World Health Organisation (WHO) criteria [60]. Solar elastosis was evaluated for all samples with available slides and adjacent dermis (131/170) using the method of Weyers et al [61]. Solar elastosis measurement was performed by a pathologist (AC) blinded to case ID number.…”

Section: Methodsmentioning

confidence: 99%

Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies

et al. 2016

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Most cancer DNA sequencing studies have prioritized recurrent non-synonymous coding mutations in order to identify novel cancer-related mutations. Although attention is increasingly being paid to mutations in non-coding regions, standard approaches to identifying significant mutations may not be appropriate and there has been limited analysis of mutational clusters in functionally annotated non-coding regions. We sought to identify clustered somatic mutations (hotspot regions across samples) in functionally annotated regions in melanoma and other cutaneous malignancies (cutaneous squamous cell carcinoma, basal cell carcinoma and Merkel cell carcinoma). Sliding window analyses revealed numerous recurrent clustered hotspot mutations in proximal promoters, with some specific clusters present in up to 25% of cases. Mutations in melanoma were clustered within ETS and Sp1 transcription factor binding motifs, had a UV signature and were identified in other cutaneous malignancies. Clinicopathologic correlation and mutation analysis support a causal role for chronic UV irradiation generating somatic mutations in transcription factor binding motifs of proximal promoters.

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Section: Methodsmentioning

confidence: 99%

Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies

et al. 2016

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“…The current WHO classification (1) is based on the melanoma classification proposed by Clark and colleagues (2) more than 30 years ago, which uses morphologic aspects of the early (radial) growth phase and the body site of the primary melanoma to distinguish four main types: superficial spreading melanoma (SSM), lentigo maligna melanoma (LMM), nodular melanoma (NM) and acral-lentiginous melanoma (ALM). The system captures archetypical patterns of clinical and histological presentation, however a portion of melanomas cannot be unequivocally categorized in any of the categories (3) and its impact on clinical care, in particular that of advanced disease has been limited.…”

Section: Classification Of Melanocytic Neoplasmsmentioning

confidence: 99%

The Molecular Pathology of Melanoma: An Integrated Taxonomy of Melanocytic Neoplasia

Bastian

2014

Annu. Rev. Pathol. Mech. Dis.

427

388

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Melanomas are comprised of multiple biologically distinct categories, which differ in cell of origin, age of onset, clinical and histologic presentation, pattern of metastasis, ethnic distribution, causative role of UV radiation, predisposing germ line alterations, mutational processes, and patterns of somatic mutations. Neoplasms are initiated by gain of function mutations in one of several primary oncogenes, typically leading to benign melanocytic nevi with characteristic histologic features. The progression of nevi is restrained by multiple tumor suppressive mechanisms. Secondary genetic alterations override these barriers and promote intermediate or overtly malignant tumors along distinct progression trajectories. The current knowledge about pathogenesis, clinical, histological and genetic features of primary melanocytic neoplasms is reviewed and integrated into a taxonomic framework.

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“…2 Initially these subsets were well received, but more recently it has been suggested that a high proportion of melanomas cannot easily be subclassified using this classification, and that because the classification appears to carry no independent prognostic significance it should be abandoned. 3 The critics, however, base their case almost exclusively on pathological observations, while Clark and colleagues were at pains to emphasize that their classification depended the combination of clinical and pathological features. As the clinical appearance and biological behaviour of the early growth phase of these four subtypes is very different, it is suggested that they are currently worth retaining.…”

Section: Clinical Variantsmentioning

confidence: 99%

Malignant melanoma: clinical variants and prognostic indicators

MacKie

2000

Clinical and Experimental Dermatology

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The four main clinicopathological subsets of melanoma are described and the arguments for their retention in a research setting presented. Further additional subsets are described, including partly regressed primary melanoma, melanoma arising in a congenital naevus and multiple primary tumours. Pathological prognostic indicators are discussed and the pre-eminent significance of tumour thickness and its interaction with ulceration described. The need for accurate personal predictive profiles as distinct from those relevant to populations is discussed, as is the need for a molecular marker of metastatic potential.

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Classification of cutaneous malignant melanoma

Cited by 77 publications

References 31 publications

Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies

Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies

The Molecular Pathology of Melanoma: An Integrated Taxonomy of Melanocytic Neoplasia

Malignant melanoma: clinical variants and prognostic indicators

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